AutismKB 2.0

Annotation Detail for A4GALT


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Basic Information Top
Gene Symbol:A4GALT ( A14GALT,A4GALT1,Gb3S,P(k),P1,PK )
Gene Full Name: alpha 1,4-galactosyltransferase
Band: 22q13.2
Quick LinksEntrez ID:53947; OMIM: 607922; Uniprot ID:A4GAT_HUMAN; ENSEMBL ID: ENSG00000128274; HGNC ID: 18149
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00603Glycosphingolipid biosynthesis - globo series
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
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Desease Name
Blood group, P system
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of A4GALT mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of A4GALT mRNAincreases expression 19152381
20064835
D001564 Benzo(a)pyrene chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of A4GALT mRNA]decreases reaction|increases expression 19152381
C007020 chlorophyllin chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of A4GALT mRNA]decreases reaction|increases expression 19152381
D003474 Curcumin Curcumin inhibits the reaction [IL1B protein results in increased expression of A4GALT mRNA]decreases reaction|increases expression 16819191
D003474 Curcumin Curcumin inhibits the reaction [TNF protein results in increased expression of A4GALT mRNA]decreases reaction|increases expression 16819191
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of A4GALT mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6917887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8016807698
MESH:D050197 Atherosclerosis Curcumin 3.5118704882
MESH:D001327 Autoimmune Diseases Curcumin 4.9819761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D002545 Brain Ischemia Curcumin 4.8716770732
MESH:D001932 Brain Neoplasms Curcumin 4.2817596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 1.8716243823 19250217 18593918 18462866
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002277 Carcinoma Curcumin 9.2618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0718414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.0218462866
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215668235 15340226 12621046 16354765 8697196
MESH:D003092 Colitis Curcumin 4.6616804969 18200517 16782535
MESH:D003103 Coloboma Curcumin 4.9218809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5519359593 16340194
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 5.3818497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.6418403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6417107852
MESH:D003928 Diabetic Nephropathies Curcumin 4.3318204486
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004381 Duodenal Ulcer Curcumin 4.4917351913
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Curcumin 4.0719297423
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Curcumin 10.4518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.4520067830
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1818462866
MESH:D005909 Glioblastoma Curcumin 3.6917596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8818462866 18829502
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9910048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.5217701891
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616354765 8697196 16959395 15340226 18606429
MESH:D006937 Hypercholesterolemia Curcumin 4.4318704882
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0118850075 18670907
MESH:D007249 Inflammation Curcumin 5.6318403477 17151092 16956363
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.6312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3218596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 4.5710783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007889 Leiomyoma Curcumin 4.9818555241
MESH:D007938 Leukemia Curcumin 3.3918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5816106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.2016106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.5617355460 18006644 18705752
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5612878042
MESH:D008107 Liver Diseases Curcumin 2.6816956363
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7021137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5918569708 20135361 20464547 6695378 20869020 20064080 17053015 18816296 18520028
MESH:D008175 Lung Neoplasms Curcumin 3.5916243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5911884234 19555203
MESH:D008223 Lymphoma Curcumin 3.8318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1816173963
MESH:D008545 Melanoma Curcumin 2.4517885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.5917263510
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009101 Multiple Myeloma Curcumin 3.7619372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.4617962980
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009361 Neoplasm Invasiveness Curcumin 4.8118495463
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.1412497104
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009423 Nervous System Neoplasms Curcumin 6.2418462866
MESH:D009765 Obesity Curcumin 2.8119297423
MESH:D010024 Osteoporosis Curcumin 3.6718719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9018462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0319401701 19196508 17440100
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Curcumin 3.2515129424 18156803 10851300 11398177 18226269 18769126 12497104
MESH:D011656 Pulmonary Emphysema Curcumin 4.8819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.4318379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012509 Sarcoma Curcumin 4.4618462866
MESH:D018805 Sepsis Curcumin 4.3818389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Curcumin 3.8616631530 19188055
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.5817053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.5818593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.8018462866
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
Pathway ID Pathway Name
KEGG:00603 Glycosphingolipid biosynthesis - globo series
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24359
    • Releated gene ID Related gene Name
    PA24359A4GALT
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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