AutismKB 2.0

Annotation Detail for PRRX1


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Basic Information Top
Gene Symbol:PRRX1 ( PHOX1,PMX1,PRX1 )
Gene Full Name: paired related homeobox 1
Band: 1q24.2
Quick LinksEntrez ID:5396; OMIM: 167420; Uniprot ID:PRRX1_HUMAN; ENSEMBL ID: ENSG00000116132; HGNC ID: 9142
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PRRX1 mRNAincreases expression 18648102
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PRRX1 mRNA]affects reaction|increases expression 18700144
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PRRX1 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of PRRX1 mRNAdecreases expression 17103032
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRRX1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PRRX1 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in increased expression of PRRX1 mRNAincreases expression 18042831
D017313 Fenretinide Fenretinide results in increased expression of PRRX1 mRNAincreases expression 16570282
C011890 kojic acid kojic acid results in decreased expression of PRRX1 mRNAdecreases expression 16595896
C041786 palm oil palm oil results in increased expression of PRRX1 mRNAincreases expression 18042831
C116926 rofecoxib rofecoxib affects the expression of PRRX1 mRNAaffects expression 17070997
C025462 sulindac sulfide sulindac sulfide results in decreased expression of PRRX1 mRNAdecreases expression 16184548
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PRRX1 mRNAincreases expression 17586704
D014212 Tretinoin Tretinoin results in decreased expression of PRRX1 mRNAdecreases expression 17045167
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D000230 Adenocarcinoma Fenretinide 3.1210697514
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000505 Alopecia Tretinoin 3.6615955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1018759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001169 Arthritis, Experimental rofecoxib 7.9316690336
MESH:D001169 Arthritis, Experimental Tretinoin 7.9316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2716292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4716935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1211289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.1216197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001932 Brain Neoplasms Fenretinide 4.4016187019
MESH:D001943 Breast Neoplasms Dietary Fats 1.9920435547
MESH:D001943 Breast Neoplasms Fenretinide 1.9916601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6716813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8516124888 18705752 15700767 16097048 15721981 15673190 16011737 16227642 3786805 16050911 16192424 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2616168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.973581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.973084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.9718788625
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 8.9716270382 17159502
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.971917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.4612391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 5.0316274795
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0316051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 7.3310977129
MESH:D002386 Cataract Tretinoin 7.3317460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.767505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7620889678
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 13.2616154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 13.2616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.199022650 19486331
MESH:D002822 Choriocarcinoma Tretinoin 5.2616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8315340226 12621046 8697196 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.839407595
MESH:D003092 Colitis Tretinoin 3.7817035595
MESH:D003110 Colonic Neoplasms rofecoxib 3.3112902858
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.469224671 10589399 9664655 8800419 9211117 16925845 9142499 17551590 14991402 9125849
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8714531868 12868966 18759878 8156756 2524372 11906362 8970840 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.553621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.078291058 6679447 7440962 9328219 1440618 18692083 9653073 18289764 9022650 11289319 18648102 16192314 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0719164858 12594235 10774834 12705907 19739265 11834606 12540782 17562736 11287661 16109766 19420014 16227642 11739529 19416960 11743745 18071297 10915739 16393943 14550746 19085960 17906064 14725611 18713872 14986274 12153990 16781746 15619225 19923254 10663392 2444490 11529661 16177239 12392966 16081117 12958197 11421492 19370779 15968718 17522070 11461765 16485898
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.0717522070 15968718 11566570 10915739 19336974 7440962 15998439 16177239 4309450 6884620 16227642 21278145 15027814 19085960 3732212 2869522 10092053 7179309 3786805 6623471 9327722 7120509
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.2718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.2718230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1416569247
MESH:D004715 Endometriosis rofecoxib 9.5015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.509294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.433581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.9711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.9716938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.0312795759 17595544 15959796 61145 16045604 16239168 12631006 19224547
MESH:D005234 Fatty Liver Dietary Fats 8.0319551842 17967931 19004024 18296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis Carbon Tetrachloride 21.8018705752
MESH:D005355 Fibrosis Dietary Fats 21.8018296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.8020067830
MESH:D005355 Fibrosis Tretinoin 21.8017994277
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005909 Glioblastoma Fenretinide 7.5616187019
MESH:D005909 Glioblastoma Tretinoin 7.5617312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2616084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6211294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.629664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.446705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.4419110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9616120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 18606429 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.7716870215
MESH:D006930 Hyperalgesia Tretinoin 7.7716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6416778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007249 Inflammation Dietary Fats 5.0020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1418457598 11836018
MESH:D007410 Intestinal Diseases rofecoxib 10.3915831440
MESH:D007410 Intestinal Diseases Tretinoin 10.3917994277
MESH:D007417 Intestinal Polyps rofecoxib 5.4311245490
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.1216580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.1215992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.2312587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.016582329
MESH:D007938 Leukemia Tretinoin 2.7917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1919225113 17294898 16935935 17339181 19075265 17107899 12679006 19035177 16766008 16891316 16140955 16823087 16331271 17361223 15748426 19642359 19029980 17217047 17301526 17649720 17506722 17712046 16788101 17368321 9834237
MESH:D007972 Leukoplakia, Oral Fenretinide 6.1416707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.349224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7216943688 11903743 21278145 16239168 17334410 17174718 11408273 17157831 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7218296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 5.0618472332 18429990 15362042 14716833 18277467 15057751 17708605 15876570 12586293 14724832 15925388 17640975 16136751 18705752 17557913 15052691 12958196 15959796 12898905 11481614 12632514 17976157 17631135 17525996 14748882 12609069 15370692 16097048 14512876 12445421 12632512 16116963 18054572 16015684 16192424 15650968 18472094 16027843 17761835 18420326 12546737 10355542 14620537 16033810 17714472 18481824 15673190 18418968 18187930 18317297 12649538 18166357 15931870 17565644 17698563 15893842 12445418 18156304 18210741 20821823 15123356 12666154 17766677 17721639 16248980 18205269 18251166 18395095 12741479 14716496 18376398 17823541 12389079 16011737 15730626 12667390 18395914 13678700 16638106 18279442 15818738 17944888 17922224 17900296 18006644 18263696 15996030 15338365 18412020 18339082 17481882 17805973 17869086
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 5.0617565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.0618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 3.9419460945 16610002 16611625 12587719 19014921 11587558 12969438 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9415830285 17285989 15720792 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4619294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.41598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental kojic acid 14.4118544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4112151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6010697514
MESH:D008527 Medulloblastoma Tretinoin 2.8017453147
MESH:D008545 Melanoma Fenretinide 3.6616270382
MESH:D008545 Melanoma Tretinoin 3.6616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008591 Meningomyelocele Tretinoin 4.5016940565
MESH:D009062 Mouth Neoplasms Fenretinide 4.3616274795
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms Fenretinide 5.4917353921 15958647
MESH:D009369 Neoplasms Tretinoin 5.4916594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.739125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.346679447
MESH:D009436 Neural Tube Defects Tretinoin 7.349142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.7616303764
MESH:D009765 Obesity Dietary Fats 2.3019632207 21332399 18674790 20518802 20132043 17217161 16723640 11836018 18457598
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010003 Osteoarthritis rofecoxib 4.4116690336
MESH:D010051 Ovarian Neoplasms Fenretinide 5.2316133793
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2316936753
MESH:D010146 Pain Acetaminophen 6.7416870215
MESH:D010146 Pain Tretinoin 6.7416870215
MESH:D010149 Pain, Postoperative rofecoxib 5.4916678543 18165598
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.6515580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6515976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Fenretinide 4.0917024972
MESH:D011507 Proteinuria Tretinoin 3.6616636307
MESH:D011625 Pterygium Tretinoin 4.8816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.243692021
MESH:D012162 Retinal Degeneration Fenretinide 9.2416303925
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1616116481 16283617
MESH:D012878 Skin Neoplasms Fenretinide 9.6816467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 9.6816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.276582329 3712494 1399818 7505956 6587162
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2717045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.8416051514
MESH:D014376 Tuberculosis Tretinoin 3.2616040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.458074119
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 5.4516720286
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 9.8716154183
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.8716129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.7218645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.7116752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D014820 Vitiligo Tretinoin 4.1216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
MESH:D009396 Wilms Tumor Tretinoin 4.0216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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