AutismKB 2.0

Annotation Detail for CPSF2


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Basic Information Top
Gene Symbol:CPSF2 ( CPSF100,KIAA1367 )
Gene Full Name: cleavage and polyadenylation specific factor 2, 100kDa
Band: 14q32.12
Quick LinksEntrez ID:53981; OMIM: 606028; Uniprot ID:CPSF2_HUMAN; ENSEMBL ID: ENSG00000165934; HGNC ID: 2325
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CPSF2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CPSF2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CPSF2 mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of CPSF2 mRNAdecreases expression 17484886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3415721981 16192424 16227642 16097048 15700767 10355542 15673190 16050911 16011737 18705752 16124888 3786805
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.953084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.9518788625
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.036135515
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.8318551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.7618551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.7616081117 18071297 16177239 17522070 10774834 12540782 19085960 12153990 16109766 14550746 15968718 11421492 15619225 16227642 12392966 14986274 16393943 10915739 12594235 19416960 16485898 11834606 17562736 11287661 10663392 12705907 11743745 17906064 19370779 12958197 11739529 14725611 18713872 11461765 19420014 19739265 2444490 16781746 19923254 11529661 19164858
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.7615968718 19336974 15998439 11566570 16177239 7179309 7120509 15027814 21278145 6884620 16227642 3732212 7440962 2869522 4309450 10092053 9327722 17522070 6623471 10915739 19085960 3786805
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5919224547 17595544 12631006 15959796 61145 12795759 16045604 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 4.0118705752
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.5316705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0011408273 21278145 16943688 16239168 16221502 17174718 17157831 17334410 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518006644 14748882 18705752 17805973 15925388 12898905 16638106 12632514 17698563 15818738 18054572 17481882 16136751 14716496 20821823 17869086 18317297 17557913 12445418 18472332 15057751 15673190 18481824 12546737 12389079 15730626 14512876 12649538 17565644 18472094 11481614 18277467 14620537 17761835 15893842 18395914 15650968 16015684 17922224 18210741 15370692 16248980 16116963 17823541 18166357 12666154 17944888 15338365 15931870 18412020 17766677 14716833 18420326 15996030 16192424 17976157 12632512 14724832 18279442 12958196 16027843 16097048 18395095 12586293 12667390 17640975 15876570 18251166 18205269 12445421 18187930 15123356 17721639 18263696 18418968 13678700 18156304 18376398 12609069 17631135 17900296 17714472 17708605 17525996 15052691 10355542 16011737 18339082 12741479 15362042 18429990 15959796 16033810
MESH:D008107 Liver Diseases Acetaminophen 4.1616610002 12969438 12587719 19460945 16611625 19014921 11587558 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1616246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.7516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.7514706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.967678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9619294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.692876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6915583823 12014681
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.5418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.547678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.2316049721
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7418551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 14.1910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 14.1910091137
MESH:D014581 Urticaria Acetaminophen 3.4410982225
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03015 mRNA surveillance pathway
REACT:78 Post-Elongation Processing of the Transcript
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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