AutismKB 2.0

Annotation Detail for BRWD1


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Basic Information Top
Gene Symbol:BRWD1 ( C21orf107,FLJ43918,N143,WDR9 )
Gene Full Name: bromodomain and WD repeat domain containing 1
Band: 21q22.2
Quick LinksEntrez ID:54014; OMIM: NA; Uniprot ID:BRWD1_HUMAN; ENSEMBL ID: ENSG00000185658; HGNC ID: 12760
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BRWD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BRWD1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BRWD1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of BRWD1 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of BRWD1 mRNAdecreases expression 17326132
D003010 Clorgyline Clorgyline results in increased expression of BRWD1 mRNAincreases expression 19691856
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of BRWD1 geneincreases mutagenesis 18353305
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.483712494
MESH:D000236 Adenoma Ethylnitrosourea 7.486695378
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Homocysteine 2.2416297937 20468076
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4611289319 1440618
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1514991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5515144691 16651633 16357521 16436596 18412241
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.847296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.787296757
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.396135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.397505956
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 12.3916003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.4317160924
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.359022650 19486331
MESH:D003324 Coronary Artery Disease Homocysteine 3.8316379339
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1514531868 11906362 2524372 8156756 8970840 12868966 11298694 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.792952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.5421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.546482804 6679447 11289319 9328219 9022650 16192314 1440618 18692083 7440962 18289764 9653073 8291058 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5414550746 19416960 19164858 14986274 12594235 16109766 19370779 17562736 11743745 12392966 19420014 11421492 11739529 12705907 18713872 15968718 12540782 11461765 19923254 19085960 2444490 10774834 11529661 11834606 15619225 12958197 10663392 16177239 10915739 16393943 17906064 17522070 11287661 16485898 12153990 16227642 14725611 18071297 19739265 16081117 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.4318357618
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.163581430
MESH:D017889 Exfoliation Syndrome Homocysteine 6.1016504073
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.466705139
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005901 Glaucoma Homocysteine 5.5916504073
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0016436596
MESH:D005910 Glioma Ethylnitrosourea 3.5818412241 16357521 16651633
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.347505956
MESH:D006330 Heart Defects, Congenital Homocysteine 4.1319638421
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.846705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.9517292331 18234410 17369066
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.468074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.8216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.8216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.826582329
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 19.8217379185
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.359327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6816610002 12587719 16611625 11587558 19460945 19784758 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.432876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.436587162 3712494 598648 1399818
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316271038 17703301 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.1315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.4115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6710838139 18041768 10767621
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008579 Meningioma Ethylnitrosourea 6.4317943659
MESH:D008591 Meningomyelocele Homocysteine 5.8916602021
MESH:D009203 Myocardial Infarction Homocysteine 3.8117412321
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.563581430
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.7616707424
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.086679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.8116651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.6616049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.664026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.4317160924
MESH:D009845 Oligospermia marker/mechanism 18353305
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.463988306
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.847296757
MESH:D010300 Parkinson Disease Homocysteine 3.6516275827
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.916228378
MESH:D011471 Prostatic Neoplasms Clorgyline 4.2419691856
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.583692021
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.5615790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.093712494 6582329 1399818 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.828074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.3510091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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