AutismKB 2.0

Annotation Detail for TLR9


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Basic Information Top
Gene Symbol:TLR9 ( CD289 )
Gene Full Name: toll-like receptor 9
Band: 3p21.2
Quick LinksEntrez ID:54106; OMIM: 605474; Uniprot ID:TLR9_HUMAN; ENSEMBL ID: ENSG00000173366; HGNC ID: 15633
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05142Chagas disease
hsa05144Malaria
hsa04620Toll-like receptor signaling pathway
Pathway IDPathway Name
Signaling by Insulin receptor
Signaling by FGFR
Signaling in Immune system
No data
Pathway IDPathway Name
P00054Toll receptor signaling pathway
Pathway IDPathway Name
500461Toll Like Receptor 9 (TLR9) Cascade
Related Diseases/Disorders Top
No data
No data
Desease Name
HEMATOLOGICAL
Cytomegalovirus Infections
CANCER
dermatitis and eczema
malaria
IMMUNE
lupus erythematosus
lung cancer
HIV
INFECTION
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TLR9 mRNAaffects expression 17562736
D000082 Acetaminophen TLR9 protein affects the reaction [Acetaminophen results in increased expression of IL1B mRNA]affects reaction|increases expression 19164858
D000082 Acetaminophen TLR9 protein results in increased susceptibility to Acetaminophenincreases response to substance 19164858
D002738 Chloroquine Chloroquine results in decreased activity of TLR9 proteindecreases activity 17727805
C408982 CPG-oligonucleotide CPG-oligonucleotide promotes the reaction [[TLR9 co-treated with MYD88] results in increased expression of HSPA1B protein]affects cotreatment|increases expression|increases reaction 17046822
C408982 CPG-oligonucleotide TLR9 protein affects the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein]affects reaction|increases expression 17727805
C408982 CPG-oligonucleotide TLR9 protein affects the reaction [CPG-oligonucleotide results in increased expression of HSP90 protein]affects reaction|increases expression 17727805
C408982 CPG-oligonucleotide TLR9 protein affects the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein]affects reaction|increases expression 17727805
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of TLR9 geneincreases mutagenesis 16724327
C013592 mangiferin mangiferin results in decreased expression of TLR9 mRNAdecreases expression 15135318
D011070 Poly I-C Poly I-C results in increased expression of TLR9 mRNAincreases expression 17087994
C025643 vinclozolin vinclozolin results in increased expression of TLR9 mRNAincreases expression 18629315
D015054 Zymosan Zymosan results in increased expression of TLR9 proteinincreases expression 17321468
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Ethylnitrosourea 3.846695378
MESH:D000707 Anaphylaxis mangiferin 5.7814669257 16536907
MESH:D000740 Anemia Zymosan 4.7818664788
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001169 Arthritis, Experimental Zymosan 4.2615188379 17659584 15944321 15142272 16872482
MESH:D050197 Atherosclerosis mangiferin 4.2318450471
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001862 Bone Resorption mangiferin 5.169881647
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1114991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5215144691 16651633 16357521 18412241 16436596
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.3617160924
MESH:D003424 Crohn Disease marker/mechanism 15236225 17914947
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003457 Cryptosporidiosis mangiferin 6.2316547730
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 4.7912093613 19028559
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 3.529881663 11315760
MESH:D003928 Diabetic Nephropathies mangiferin 5.0019706694 19960420
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6411287661 15968718 12153990 12392966 16177239 19923254 16109766 15619225 14725611 16393943 16781746 19370779 12705907 19420014 17906064 17562736 12958197 12594235 10915739 16485898 11739529 17522070 11834606 10774834 16227642 19164858 19085960 2444490 12540782 19739265 16081117 11529661 14986274 18071297 11461765 11743745 10663392 19416960 11421492 14550746 18713872
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.3618357618
MESH:D004487 Edema Zymosan 4.227907874
MESH:D005234 Fatty Liver mangiferin 4.7115975614
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9816436596
MESH:D005910 Glioma Ethylnitrosourea 3.5718412241 16651633 16357521
MESH:D015745 Granuloma, Foreign-Body marker/mechanism 19797157
MESH:D015769 Granuloma, Respiratory Tract marker/mechanism 19797157
MESH:D006331 Heart Diseases mangiferin 4.5512093613
MESH:D006505 Hepatitis Zymosan 4.9819110552
MESH:D006561 Herpes Simplex mangiferin 5.3410715843
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006946 Hyperinsulinism mangiferin 5.209881663 11315760
MESH:D006949 Hyperlipidemias mangiferin 5.1115975614
MESH:D006967 Hypersensitivity mangiferin 4.9216536907
MESH:D007154 Immune System Diseases mangiferin 6.2316076520
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation marker/mechanism 19797157
MESH:D007249 Inflammation mangiferin 6.3415222974
MESH:D007249 Inflammation Zymosan 6.3411289658 8014878
MESH:D007333 Insulin Resistance mangiferin 4.4911315760
MESH:D043183 Irritable Bowel Syndrome Zymosan 6.1717553498
MESH:D007511 Ischemia mangiferin 5.5716806951
MESH:D007674 Kidney Diseases Acetaminophen 6.8112587719 15629191
MESH:D007674 Kidney Diseases mangiferin 6.8112093613
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.1317379185
MESH:D007859 Learning Disorders mangiferin 5.2619182383
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 4.7915498116
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008106 Liver Cirrhosis, Experimental Poly I-C 3.4718166357
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19460945 11587558 12969438 19784758 19014921 16610002 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.3016019985 17703301 6695378 16271038
MESH:D008175 Lung Neoplasms mangiferin 3.3018520028 18569708 18816296
MESH:D008223 Lymphoma Ethylnitrosourea 4.1115790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.3515375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6518041768 10767621 10838139
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008569 Memory Disorders mangiferin 5.2119182383
MESH:D008579 Meningioma Ethylnitrosourea 6.3617943659
MESH:D008708 Methemoglobinemia Chloroquine 5.973537620
MESH:D009102 Multiple Organ Failure Zymosan 5.4418160304 10890648 10479408 15241586 12130978 15213630 15834315 15259001 17724436 12879239
MESH:D009203 Myocardial Infarction mangiferin 3.9317052832 16584858 19172585 16697266 16538859
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.7116707424
MESH:D009410 Nerve Degeneration mangiferin 4.7917433543
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.7516003739 16651423 17160924
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.3617160924
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010300 Parkinson Disease mangiferin 3.7817433543
MESH:D010518 Periodontitis mangiferin 5.9819026997
MESH:D010538 Peritonitis Zymosan 5.1915259001 18977430 19641140 18557954 18760300 11985352 17371808 15979727 17826846 19088179 14761945
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.7815830843
MESH:D012555 Schistosomiasis mansoni marker/mechanism 19797157
MESH:D018805 Sepsis Zymosan 4.8511441115
MESH:D012772 Shock, Septic mangiferin 5.5715177305
MESH:D013276 Stomach Ulcer mangiferin 4.5117918041
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.5015790496
MESH:D014235 Trichinellosis mangiferin 6.4414669257
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Zymosan 5.7811006244
Pathway ID Pathway Name
KEGG:05143 African trypanosomiasis
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:05144 Malaria
KEGG:05162 Measles
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38010
    • No data
    Releated disease ID Related disease Name
    PA444859Malaria
    Releated drug ID Related drug Name
    PA449972imiquimod
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00608 - Chloroquine Antirheumatic Agents;Antimalarials;Amebicides
    DB01611 antagonist Hydroxychloroquine Antirheumatic Agents;Enzyme Inhibitors;Antimalarials;Dermatologic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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