AutismKB 2.0

Annotation Detail for KCNK10


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Basic Information Top
Gene Symbol:KCNK10 ( FLJ43399,K2p10.1,TREK-2,TREK2 )
Gene Full Name: potassium channel, subfamily K, member 10
Band: 14q31.3
Quick LinksEntrez ID:54207; OMIM: 605873; Uniprot ID:KCNKA_HUMAN; ENSEMBL ID: ENSG00000100433; HGNC ID: 6273
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04971Gastric acid secretion
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNK10 mRNAaffects expression 16483693
D005419 Flavonoids Flavonoids results in decreased expression of KCNK10 mRNAdecreases expression 18035473
C406082 monomethylarsonous acid [monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of KCNK10 promoteraffects acetylation|affects methylation 18448484
C017947 sodium arsenite [sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of KCNK10 promoteraffects acetylation|affects methylation 18448484
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6317306315 16712894
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0117306315 15276417 16507464
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 8.0519716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 8.0520056578 19524636
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D007248 Infertility, Male sodium arsenite 3.2412646999 15346721
MESH:D007249 Inflammation Flavonoids 2.8217296493
MESH:D007674 Kidney Diseases sodium arsenite 3.0020008137
MESH:D008113 Liver Neoplasms sodium arsenite 2.4816712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9017306315 19931552 16712894 17077188 15276417
MESH:D008545 Melanoma sodium arsenite 2.0719082730 16487513
MESH:D009369 Neoplasms sodium arsenite 2.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3812854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5317306315 15276417
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D012871 Skin Diseases monomethylarsonous acid 3.4517431481
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 5.9420375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.9417306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1611813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
KEGG:04971 Gastric acid secretion
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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