AutismKB 2.0

Annotation Detail for POLA1


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Basic Information Top
Gene Symbol:POLA1 ( DKFZp686K1672,POLA,p180 )
Gene Full Name: polymerase (DNA directed), alpha 1, catalytic subunit
Band: Xp22.11-p21.3
Quick LinksEntrez ID:5422; OMIM: 312040; Uniprot ID:DPOLA_HUMAN; ENSEMBL ID: ENSG00000101868; HGNC ID: 9173
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03030DNA replication
hsa00230Purine metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Chromosome Maintenance
Pathway IDPathway Name
200027E2F transcription factor network
Pathway IDPathway Name
P00017DNA replication
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of POLA1 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen results in decreased expression of POLA1 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of POLA1 proteinaffects expression 20106945
D016590 Aphidicolin Aphidicolin results in decreased activity of POLA1 proteindecreases activity 14975937
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of POLA1 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of POLA1 mRNAdecreases expression 17942131
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of POLA1 mRNAdecreases expression 20382639
C095105 bexarotene bexarotene results in increased expression of POLA1 mRNAincreases expression 16648578
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of POLA1 mRNAdecreases expression 17942131
D016572 Cyclosporine Cyclosporine results in decreased expression of POLA1 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of POLA1 mRNAdecreases expression 17942131
C014347 decitabine decitabine affects the methylation of POLA1 geneaffects methylation 17630775
D002945 Cisplatin POLA1 protein results in increased susceptibility to Cisplatinincreases response to substance 16734730
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of POLA1 mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of POLA1 mRNA]decreases reaction|increases expression 17854601
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of POLA1 mRNAincreases expression 15766595
C020326 ferric nitrilotriacetate ferric nitrilotriacetate results in increased expression of POLA1 mRNAincreases expression 10854235
D005472 Fluorouracil Fluorouracil results in decreased expression of POLA1 mRNAdecreases expression 19219653
C051890 irinotecan POLA1 protein results in increased susceptibility to irinotecanincreases response to substance 16734730
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of POLA1 mRNAincreases expression 12057914
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of POLA1 mRNAincreases expression 20713471
C008493 methylselenic acid methylselenic acid results in decreased expression of POLA1 mRNAdecreases expression 12517777
D011794 Quercetin Quercetin results in decreased expression of POLA1 mRNAdecreases expression 15309432
C059514 resveratrol resveratrol results in decreased expression of POLA1 mRNAdecreases expression 15767336
D012402 Rotenone Rotenone results in increased expression of POLA1 mRNAincreases expression 18191903
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of POLA1 mRNAincreases expression 15667827
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7014514962 11752688 15322242
MESH:D058186 Acute Kidney Injury Cisplatin 8.4212690470 17670903 15814532
MESH:D058186 Acute Kidney Injury resveratrol 8.4216538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.8911850527 18653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9520127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 6.9517638652 11798837
MESH:D000230 Adenocarcinoma Fluorouracil 6.9517638652
MESH:D000236 Adenoma Benzo(a)pyrene 15.306695378
MESH:D000236 Adenoma Diethylnitrosamine 15.306695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 15.3010545420 6695378
MESH:D000236 Adenoma resveratrol 15.3015688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5519061943 17162532 17620307 19052882 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5516835633
MESH:D000544 Alzheimer Disease resveratrol 2.5416183991 16162502
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3315469931
MESH:D000740 Anemia Fluorouracil 8.2416511603 15504547 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2411748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1017084956
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001169 Arthritis, Experimental resveratrol 3.4117115116
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8215336622
MESH:D050197 Atherosclerosis Methylcholanthrene 6.6711922910
MESH:D050197 Atherosclerosis resveratrol 6.6717967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Quercetin 4.2619761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.7314601052
MESH:D002545 Brain Ischemia resveratrol 4.1317600658
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 9.5411921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 9.5417474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 9.5416818667 16344269
MESH:D001943 Breast Neoplasms Cisplatin 9.5418382427 19526202
MESH:D001943 Breast Neoplasms decitabine 9.5419208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.5417474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.5415324884 17129689
MESH:D001943 Breast Neoplasms Fluorouracil 9.5416110121 15136595 18357371 16557594 16595493 19217205 18608205
MESH:D001943 Breast Neoplasms Methylcholanthrene 9.5417474063
MESH:D001943 Breast Neoplasms Quercetin 9.5418628248
MESH:D001943 Breast Neoplasms resveratrol 9.5416393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 9.5420435547
MESH:D002105 Cadmium Poisoning Quercetin 5.3916962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5216051944
MESH:D002277 Carcinoma Fluorouracil 13.2917121937
MESH:D002277 Carcinoma Methylcholanthrene 13.2910545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.2916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.513084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.5112907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 16.5117982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.5118506893 18788625 19208518 16540662 17173139 10737359 19052882 17055752 16328049 21159647 20214788 18971187 3084413 20007298 18210153 18494052 17138121 16878318 16502159 18785209 16935385 19394651 17428255 18691550 19171122 20512989 17978847 18056438 17761372 20084675 16569478 19519916 11831363 19383236 20935162 19919837 19539802 18978308 16288022 16779866 20727157 20101231 10672840 16698587 20524982 19418558 18393292 19822196 19701751 3581430 20432363 19107877 18665156 16681979 16830150 19335982 16807293 20514400 17162532
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.5116924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.5117045692 18930000 16799960 17971768 16332177 17088986
MESH:D006528 Carcinoma, Hepatocellular Quercetin 16.5119519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.5119321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4416675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.7016247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.7012023789 16685392
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8017234771
MESH:D002292 Carcinoma, Renal Cell ferric nitrilotriacetate 6.898340253
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.8918695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.8820419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 13.8817066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.8819215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.8817066447 16757204 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell resveratrol 13.8816227395
MESH:D006332 Cardiomegaly Quercetin 6.5319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.5318670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases resveratrol 3.3715458977
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.0420889678
MESH:D002471 Cell Transformation, Neoplastic Aphidicolin 20.048243401
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.0412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.042727394 21159647 7505956 17174075
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 20.0416192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Cyclosporine 2.8019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 12621046 15340226 15668235 16354765
MESH:D003092 Colitis resveratrol 3.9816474422
MESH:D003110 Colonic Neoplasms decitabine 10.8117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 10.8117725105 18772588 16340194 17172411 16510598 17016597 15001691 17018589 17287894 17169374
MESH:D003110 Colonic Neoplasms irinotecan 10.8117725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 10.8111134977 17191121 16640504 17148506 15741050 19440933 19056647
MESH:D003110 Colonic Neoplasms resveratrol 10.8116338953
MESH:D015179 Colorectal Neoplasms Cisplatin 8.2115273666
MESH:D015179 Colorectal Neoplasms decitabine 8.2118981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 8.2117255274 18448328 15148649 16391804 16331619 15289873 17016601 14970324 20501625 16282729 17454858 18949393 18383874 18288408 17594712 18802399 16524972 17094418 17401013 17695437 18509181 16303861
MESH:D015179 Colorectal Neoplasms irinotecan 8.2115273666 17159606 16391804 18509181 18259882 17454858 16303861
MESH:D015179 Colorectal Neoplasms Quercetin 8.2118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 8.2116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6616507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4116002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.6416733453
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 8.1419496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.1416873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.8316286809
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8611421492 18071297 12153990 16109766 19370779 16781746 16485898 19416960 12392966 10915739 12594235 11739529 10663392 12705907 17562736 19739265 10774834 11287661 12540782 11461765 14550746 19085960 15619225 11834606 19164858 16081117 17522070 16227642 2444490 12958197 16393943 14986274 19923254 16177239 11529661 14725611 18713872 17906064 15968718 11743745 19420014
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.8619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Cisplatin 7.8112649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8111462148
MESH:D004487 Edema resveratrol 6.418985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.8817872969
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9619294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.3716804899 15700306
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2415821434 17637181 15328337
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7017923197
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.0916530937
MESH:D004938 Esophageal Neoplasms Cisplatin 10.0916481741 15464296 17638652 15173087 16785472
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.0917638652 16337965 16785472 16481741 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Cyclosporine 7.2619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 7.2621071580 20387270
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5616513791 16534752 15751030 16611131 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005334 Fever Lipopolysaccharides 3.8811852909 9205823
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7914633661 10962813
MESH:D005355 Fibrosis Cyclosporine 13.9012639820 12168785
MESH:D005355 Fibrosis Quercetin 13.9019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9020067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Quercetin 3.2919804834
MESH:D005910 Glioma Fluorouracil 5.9916145905
MESH:D005910 Glioma Quercetin 5.9917643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.4615464296 15102660
MESH:D006258 Head and Neck Neoplasms decitabine 12.4619215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.4615102660 18337622 15162350
MESH:D034381 Hearing Loss Cisplatin 4.1719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2516366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.0316876885
MESH:D006689 Hodgkin Disease Cisplatin 3.4716170182 16200630
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006937 Hypercholesterolemia resveratrol 3.8717188708
MESH:D006943 Hyperglycemia Quercetin 3.9018262572 11834736
MESH:D006949 Hyperlipidemias resveratrol 3.8916873680
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2914722030 12960047
MESH:D006973 Hypertension Cyclosporine 8.2410903974
MESH:D006973 Hypertension Quercetin 8.2418356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2418850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1717488730
MESH:D007021 Hypospadias Diethylstilbestrol 4.4316002989
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5017600658
MESH:D007246 Infertility Diethylstilbestrol 4.2115036965
MESH:D007248 Infertility, Male decitabine 3.1017581917
MESH:D007249 Inflammation Diethylnitrosamine 11.3418785209
MESH:D007249 Inflammation Lipopolysaccharides 11.3417237260 9205823 12878042 17963957 17255318
MESH:D007249 Inflammation resveratrol 11.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.3412878042 12200463
MESH:D007251 Influenza, Human Quercetin 10.6916624496
MESH:D007251 Influenza, Human resveratrol 10.6916624496
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007627 Keloid Quercetin 4.8017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9915464296
MESH:D007674 Kidney Diseases Acetaminophen 18.1712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 18.1712231392 15190930 12649298 19839026 18289764
MESH:D007674 Kidney Diseases Cyclosporine 18.1710903974 8314463 18776723
MESH:D007674 Kidney Diseases ferric nitrilotriacetate 18.1718617210 15834431
MESH:D007674 Kidney Diseases Quercetin 18.1716962696
MESH:D007680 Kidney Neoplasms Cyclosporine 16.8412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 16.8414681315 16762066 15003126
MESH:D007680 Kidney Neoplasms ferric nitrilotriacetate 16.849667754 18055543
MESH:D007680 Kidney Neoplasms Fluorouracil 16.8416985049
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6411231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9117184923
MESH:D007938 Leukemia decitabine 6.3218980019 19235587
MESH:D007938 Leukemia Quercetin 6.3217468513
MESH:D007951 Leukemia, Myeloid decitabine 3.8617236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3519387464 17679729 18460780 18206229 18704418 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3118055864
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4816087638
MESH:D007970 Leukopenia Lipopolysaccharides 4.5515821434
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7418522880 18407596 20032147 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.4712741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008107 Liver Diseases Acetaminophen 3.7712969438 16610002 11587558 16611625 19460945 12587719 19784758 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1017185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.989163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.9821137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.9818648771 15885732 19426721 21047994 21278145 16942905 20137499 19090486 12771043 19642983 19638242 21167192 18644402 21071580 9163691 20118626 19254457 2862719 19812893 20405173 20452335 19551842 18977376 2422723 20101389 10737359 19499222 20492335 19256749 19073162 12112319 19850985 19294768 20501860 19690152 19427195 18754104 20583210 15175105 20434301 19833225 19996281 18978307 19255062
MESH:D008113 Liver Neoplasms Diethylstilbestrol 24.9816712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 24.9816603448 17045692 18383874 15113037
MESH:D008113 Liver Neoplasms Quercetin 24.9818980244
MESH:D008113 Liver Neoplasms resveratrol 24.9819321006 19812893 20405173 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.9816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.668603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.6618544905 19009564 18079962 3124819 18775883 19004024 18253720 19539802 18164116 18308698 17942915 17854601 2563599 18093689 16842330 18282651 16267830 21159647 17174075 9362446 19126423 19519916
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.66598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.6619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6612151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.8621114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 15.0714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 15.076695378 20869020 20135361 17053015 18816296 20064080 20464547 18520028 18569708
MESH:D008175 Lung Neoplasms bexarotene 15.0717849452
MESH:D008175 Lung Neoplasms Cisplatin 15.076189445 17225452 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 15.0720970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 15.0715246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 15.0720970405 11893704 21163286 6695378 16271038 1399818 10545420 9230183 7750092 15390079 17909032 16337739 20512841
MESH:D008175 Lung Neoplasms Quercetin 15.0716280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 15.0711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6415086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0015166399
MESH:D008223 Lymphoma decitabine 7.3719470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.3715700306
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7514749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.0011161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3616002989
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0915688416
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 9.6911921183
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.6919196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.698985016 11606380
MESH:D008545 Melanoma Cisplatin 5.1016248763 12883367 16432458 11135225 18505091 12374674 12393984 17023156 16809738 18176117 17761969 18332650 15577323
MESH:D008545 Melanoma decitabine 5.1016505122 17785578
MESH:D008545 Melanoma resveratrol 5.1017992120
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Cisplatin 3.1917638057
MESH:D008659 Metabolic Diseases resveratrol 4.2417112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.1416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.1416757204 18986760
MESH:D052016 Mucositis irinotecan 4.8617159606
MESH:D009101 Multiple Myeloma decitabine 7.1518172295
MESH:D009101 Multiple Myeloma resveratrol 7.1516267019 17049120 17164350 16490592 17935668 14749477
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7217962980
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3016882708 19010910 18608210 19157545
MESH:D009203 Myocardial Infarction Quercetin 5.8419595682
MESH:D009203 Myocardial Infarction resveratrol 5.8416317513 17188708 17125593 16456233 17015251 16525036
MESH:D017202 Myocardial Ischemia resveratrol 8.6117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.6112213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6819207477
MESH:D009205 Myocarditis resveratrol 4.6117322642
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.769029167 3581430
MESH:D009362 Neoplasm Metastasis irinotecan 5.7618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 18.8511141357
MESH:D009369 Neoplasms Cisplatin 18.8516773208
MESH:D009369 Neoplasms decitabine 18.8519116145 17925555 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 18.8515313581
MESH:D009369 Neoplasms Fluorouracil 18.8516928823 18600527 18239605
MESH:D009369 Neoplasms Quercetin 18.8515185748
MESH:D009374 Neoplasms, Experimental resveratrol 3.858985016
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.6319196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3415464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.7618619942 17356569 15790535
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.1511399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1514600291
MESH:D009447 Neuroblastoma Cisplatin 6.978761367
MESH:D009447 Neuroblastoma irinotecan 6.978761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.3318514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.3320387270
MESH:D019636 Neurodegenerative Diseases resveratrol 13.3317652729
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.968761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.968761367
MESH:D020078 Neurogenic Inflammation Quercetin 10.2217929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3416436463
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 9.7319495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.7317513867
MESH:D010051 Ovarian Neoplasms Cisplatin 7.7719769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms decitabine 7.7719331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 7.7719005980
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 15.7619003803
MESH:D010190 Pancreatic Neoplasms decitabine 15.7619294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 15.7616540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 15.7619003803 16500647 16929163 15113037
MESH:D010190 Pancreatic Neoplasms Quercetin 15.7616965848
MESH:D010300 Parkinson Disease Rotenone 2.9215451049 18191903 19232380 16140633 18619942 19114014 11535288 16412576 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 3.9415795934 15927086 15574749 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1615464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5215687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.1917638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.4011605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.5712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.572563599
MESH:D011230 Precancerous Conditions Quercetin 14.5719056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.4317184923
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.4316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.4311222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.5817616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8915046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Quercetin 1.8914715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 1.8917718901 17804756 15767336 17636462 16731767 17675339
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8815538739 18286688 18722050 16160472
MESH:D051437 Renal Insufficiency Cisplatin 4.2615464296
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4316325855
MESH:D015427 Reperfusion Injury resveratrol 3.2016314181 17520802 16317513 15827377 17058453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2619155313
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2814601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.3916862918
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0319755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 9.0315837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0316192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1915464296
MESH:D013088 Spermatocele Diethylstilbestrol 4.5616002989 16709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 8.112093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 8.1118396642 15958060 17522103
MESH:D013274 Stomach Neoplasms decitabine 8.1119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 8.1118456281
MESH:D013274 Stomach Neoplasms Fluorouracil 8.1116951190 19084572 18396642 17498489 19015929 16424979 18567086 15786421 17522103 17172411
MESH:D013274 Stomach Neoplasms irinotecan 8.1115723263
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3516321402
MESH:D013736 Testicular Neoplasms Cisplatin 4.4915464296 17225452
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0315821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms decitabine 6.9017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.907505956
MESH:D014062 Tongue Neoplasms Fluorouracil 9.5416280240
MESH:D014062 Tongue Neoplasms resveratrol 9.5416227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.2017053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 15.2012973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms decitabine 15.2017616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 15.2017306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Quercetin 15.2016720314
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 21.5716803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 21.5716175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 21.5716803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 21.5717473185
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.2916690809 15809267
MESH:D014594 Uterine Neoplasms resveratrol 9.2917044934
MESH:D014604 Uveal Neoplasms decitabine 4.7617785578
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.5815577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.5816002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1517488730
MESH:D014839 Vomiting Cisplatin 4.5711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:22172 Chromosome Maintenance
KEGG:03030 DNA replication
REACT:383 DNA Replication
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162399856
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445742Stomach Neoplasms
    Releated drug ID Related drug Name
    PA449957ibuprofen
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00242 antagonist Cladribine Antineoplastic Agents;Immunosuppressive Agents
    DB00631 antagonist Clofarabine Antineoplastic Agents;Antimetabolites;Purine analogues
    DB01073 antagonist Fludarabine Antineoplastic Agents;Antimetabolites;Immunosuppressive Agents;Antimetabolites, Antineoplastic
    DB01280 antagonist Nelarabine Antineoplastic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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