AutismKB 2.0

Annotation Detail for SNTG2


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Basic Information Top
Gene Symbol:SNTG2 ( G2SYN,MGC133174,SYN5 )
Gene Full Name: syntrophin, gamma 2
Band: 2p25.3
Quick LinksEntrez ID:54221; OMIM: 608715; Uniprot ID:SNTG2_HUMAN; ENSEMBL ID: ENSG00000172554; HGNC ID: 13741
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SNTG2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of SNTG2 mRNAaffects expression 17562736
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SNTG2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of SNTG2 mRNAdecreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 4.186195326
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.7117620307
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder marker/mechanism 17292328
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.827296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.823084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8217173139 1701930 20935162 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.904080065
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20808228
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4719486331 9022650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4412868966 11298694 8156756 8970840 14531868 18759878 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.022952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.059022650 1440618 18648102 7440962 18692083 6679447 11289319 16192314 9653073 9328219 18289764 6482804 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0511421492 17562736 16781746 12594235 17522070 14986274 18071297 19164858 14550746 10774834 14725611 16227642 11529661 19420014 19416960 11834606 12958197 12392966 19739265 19085960 10915739 18713872 12540782 16177239 11287661 11743745 17906064 11739529 12705907 16109766 11461765 19923254 2444490 10663392 16485898 16393943 19370779 12153990 16081117 15968718 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004421 Dystonia Phenobarbital 4.531851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.763659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.7411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.966401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.907750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.763659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006529 Hepatomegaly Phenobarbital 4.1316109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.898074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D008103 Liver Cirrhosis Phenobarbital 3.1021047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 4.2219014921 16610002 19460945 12587719 19784758 11587558 12969438 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.2219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.4319482888 19073162 8742319 15975961 21047994 19812893
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.80598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.801399818 17172636 18308698 6150874 2563599
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.2217484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.874026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010018 Osteomalacia Phenobarbital 5.1117016548
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.6116965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011230 Precancerous Conditions Phenobarbital 4.042563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.3612752131
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012640 Seizures Phenobarbital 2.973137016 11442880 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.566407741
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.306587162 6582329 7505956 3712494 1399818
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.301399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
MESH:D014581 Urticaria Acetaminophen 3.5010982225
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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