AutismKB 2.0

Annotation Detail for POLG


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Basic Information Top
Gene Symbol:POLG ( FLJ27114,MDP1,PEO,POLG1,POLGA,SANDO,SCAE )
Gene Full Name: polymerase (DNA directed), gamma
Band: 15q26.1
Quick LinksEntrez ID:5428; OMIM: 174763; Uniprot ID:DPOG1_HUMAN; ENSEMBL ID: ENSG00000140521; HGNC ID: 9179
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1791Neuropathy
1825Oligospermia
1837Polyneuropathy
1867Liver failure
1953Nervous system disease
1823Infertility, Male
2170Mitochondrial disease
2211Chronic progressive external ophthalmoplegia
Desease Name
height
Infertility, Male
DEVELOPMENTAL
REPRODUCTION
Desease Name
Height
Desease Name
MNGIE without leukoencephalopathy
Alpers syndrome
Progressive external ophthalmoplegia, autosomal recessive
Spinocerebellar ataxia with epilepsy
Progressive external ophthalmoplegia, autosomal dominant, with or without hypogonadism
Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of POLG mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of POLG mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of POLG mRNAincreases expression 16751229
C014949 acetylhydrazine acetylhydrazine results in decreased expression of POLG mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POLG mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of POLG mRNAincreases expression 20504355
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of POLG mRNAaffects cotreatment|decreases expression 20360939
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of POLG mRNAincreases expression 17179207
D002248 Carbon Monoxide Carbon Monoxide results in increased expression of POLG proteinincreases expression 17179207
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLG mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of POLG mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of POLG mRNAaffects cotreatment|affects expression 17602206
D005472 Fluorouracil POLG protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
C029424 hydrazine hydrazine results in decreased expression of POLG mRNAdecreases expression 15282401
D008713 Methimazole Methimazole results in decreased expression of POLG mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in decreased expression of POLG mRNAdecreases expression 17403546
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POLG mRNAaffects binding|increases activity|increases expression 19710929
D011441 Propylthiouracil Propylthiouracil results in decreased expression of POLG mRNAdecreases expression 17403546
C017947 sodium arsenite sodium arsenite results in decreased expression of POLG mRNAdecreases expression 12760830
D014284 Triiodothyronine [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNAaffects cotreatment|decreases expression 14761676
D013749 Tetrachlorodibenzodioxin [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of POLG mRNAaffects cotreatment|decreases expression 14761676
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.3717638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.983712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.986695378
MESH:D000236 Adenoma Diethylnitrosamine 10.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.0817162532 19052882 18056438 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000740 Anemia Fluorouracil 8.5515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.991440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.1319483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 15.1319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.1312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9217474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9217474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.9216110121 16557594 19217205 15136595 18357371 18608205 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.803581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.803084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.8017162532 16328049 20935162 16502159 20101231 20514400 18785209 20432363 19171122 19052882 20524982 17055752 20512989 10737359 16807293 20214788 19107877 17173139 19383236 18691550 19822196 19418558 16779866 20727157 3581430 18210153 19394651 16288022 20084675 18393292 17978847 10672840 19519916 18665156 11831363 16681979 19539802 17761372 16698587 3084413 19701751 19208518 20007298 18788625 18494052 18971187 18506893 16878318 17138121 19919837 16540662 18056438 18978308 16935385 19335982 16569478 16830150 21159647 17428255
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.8016799960 17971768 16332177 17045692 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.8017306315 16507464 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.437296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.4318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.4617066447 16280240 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.047505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.0421159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.0419524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.7319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 7.7319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 15668235 16354765 15340226 8697196
MESH:D003092 Colitis Carbon Monoxide 5.6016365149
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2316510598 17169374 17725105 18772588 15001691 17172411 17018589 16340194 17287894 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0015148649 18509181 18949393 17401013 18288408 20501625 16391804 16303861 18448328 16282729 16331619 17695437 17016601 18802399 15289873 16524972 17094418 17454858 14970324 18383874 17594712 17255274
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.7712868966 11906362 2524372 8970840 8156756 11298694 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.453621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8411289319 6679447 18648102 16192314 9328219 18289764 6482804 7440962 9022650 8291058 9653073 18692083 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8411739529 17522070 12392966 11287661 19416960 16109766 14550746 2444490 14725611 12594235 11461765 18071297 12540782 14986274 10663392 16081117 11743745 12958197 19420014 19739265 18713872 12705907 19370779 10915739 16393943 15619225 12153990 19164858 16781746 16227642 16485898 11421492 17562736 16177239 11529661 15968718 10774834 19085960 17906064 11834606 19923254
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.8419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.173581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.1716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.1715173087 16785472 17638652 16481741 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Diethylnitrosamine 7.5521071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 7.5519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.996705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 11.347505956
MESH:D006042 Goiter perchlorate 11.3418801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.3615162350 15102660 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.476705139
MESH:D006529 Hepatomegaly pirinixic acid 8.1318467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 12621046 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9015034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D006980 Hyperthyroidism Methimazole 5.5714678291
MESH:D007037 Hypothyroidism Methimazole 11.8218031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.8218031379 8137927
MESH:D007248 Infertility, Male sodium arsenite 2.9615346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 4.8218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.5510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.998074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007674 Kidney Diseases Acetaminophen 10.0215629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 10.0215369732
MESH:D007674 Kidney Diseases sodium arsenite 10.0220008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.366582329
MESH:D007680 Kidney Neoplasms Fluorouracil 7.3616985049
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9616766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8020032147 19638242 18407596 18665156 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.1715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1212878042
MESH:D008107 Liver Diseases Acetaminophen 6.6811587558 16611625 16610002 12969438 12587719 19784758 19014921 19460945
MESH:D008107 Liver Diseases Carbon Monoxide 6.6817173083
MESH:D008107 Liver Diseases Diethylnitrosamine 6.6817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.6721137059 20195826
MESH:D008113 Liver Neoplasms Clofibric Acid 21.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.6718977376 19256749 2422723 19638242 19294768 20137499 20452335 19499222 19090486 21047994 18978307 21278145 19551842 20434301 18648771 19690152 20118626 20492335 15175105 10737359 18754104 20405173 20101389 19850985 20501860 16942905 19254457 2862719 19812893 12771043 18644402 19426721 12112319 15885732 19427195 19255062 19996281 19833225 20583210 21167192 9163691 21071580 19073162 19642983
MESH:D008113 Liver Neoplasms Fluorouracil 21.6717045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 21.6720007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 21.6716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.6716984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.623712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.6218308698 18079962 17854601 18544905 3124819 18775883 19126423 17174075 21159647 2563599 17942915 19009564 18253720 19539802 18282651 19004024 9362446 19519916 16842330 16267830 18164116 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6212151625
MESH:D008171 Lung Diseases sodium arsenite 3.1419095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5317053015 18816296 18569708 6695378 18520028 20135361 20464547 20064080 20869020
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5320970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Fluorouracil 6.5315246190
MESH:D008175 Lung Neoplasms sodium arsenite 6.5317306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008545 Melanoma sodium arsenite 2.0319082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
OMIM:203700 MITOCHONDRIAL DNA DEPLETION SYNDROME 4A (ALPERS TYPE) marker/mechanism
MESH:C537477 Mitochondrial neurogastrointestinal encephalopathy syndrome marker/mechanism
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.4116757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.643581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.643581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 11.6811141357
MESH:D009369 Neoplasms Fluorouracil 11.6816928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 11.6817405874
MESH:D009369 Neoplasms sodium arsenite 11.6811559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6320056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.166679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.1612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.0618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.0620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.384026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.993988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4215276417 17306315
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.2716540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2719003803 16929163 16500647 15113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.447296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.446228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.512563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611222880 11118676 11399792 11896295
OMIM:157640 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL DOMINANT, 1 marker/mechanism
OMIM:258450 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE marker/mechanism
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5819082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5816039940
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9718722050 15538739 18286688 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.343692021
MESH:C537583 Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis marker/mechanism
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2810029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 9.2819524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2816192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3318456281
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3317172411 18396642 16424979 18567086 19084572 17522103 16951190 19015929 15786421 17498489
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.843712494 1399818 6587162 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.847505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 11.8415710170
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9516280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.198074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.1917053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.1916712894 16452187 17306315 11723127
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.3516803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3511813266
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33500
    • No data
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA164925725Toxic liver disease
    PA444997Muscular Diseases
    PA157379134Myalgia unspecified
    Releated drug ID Related drug Name
    PA451846valproic acid
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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