AutismKB 2.0

Annotation Detail for POLR2A


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Basic Information Top
Gene Symbol:POLR2A ( MGC75453,POLR2,POLRA,RPB1,RPBh1,RPO2,RPOL2,RpIILS,hRPB220,hsRPB1 )
Gene Full Name: polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Band: 17p13.1
Quick LinksEntrez ID:5430; OMIM: 180660; Uniprot ID:RPB1_HUMAN; ENSEMBL ID: ENSG00000181222; HGNC ID: 9187
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03020RNA polymerase
hsa00230Purine metabolism
hsa05016Huntington's disease
hsa01100Metabolic pathways
Pathway IDPathway Name
Elongation arrest and recovery
Regulatory RNA pathways
Pausing and recovery of elongation
Transcription
DNA Repair
mRNA Processing
Gene Expression
HIV Infection
No data
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
500366MicroRNA (miRNA) Biogenesis
500065Formation of transcription-coupled NER (TC-NER) repair complex
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2118Adenovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of POLR2A mRNAaffects expression 21346803
C120275 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone results in decreased phosphorylation of POLR2A proteindecreases phosphorylation 17631934
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of POLR2A mRNAdecreases expression 14583596
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of POLR2A mRNAincreases expression 14583596
C006632 arsenic trioxide arsenic trioxide results in increased expression of POLR2A mRNAincreases expression 20458559
D001241 Aspirin Aspirin results in increased expression of POLR2A mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of POLR2A mRNAincreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of POLR2A mRNAincreases expression 20127859
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of POLR2A mRNAaffects expression 16239168
C415250 deferasirox deferasirox results in decreased phosphorylation of POLR2A proteindecreases phosphorylation 17631934
C029938 nickel sulfate nickel sulfate results in increased expression of POLR2A mRNAincreases expression 16780908
D012643 Selenium Selenium results in increased expression of POLR2A mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of POLR2A mRNAincreases expression 18175754
D013752 Tetracycline Tetracycline results in increased expression of POLR2A mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury nickel sulfate 4.4212718980 19131640 16100012 11954676
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.7920485159 12372130
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D001932 Brain Neoplasms Aspirin 4.5215481559
MESH:D001943 Breast Neoplasms Aspirin 2.4415161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4420146248 17474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9215700767 16097048 18705752 16227642 15721981 16011737 16050911 15673190 16192424 16124888 3786805 10355542
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6811135700 16217749 15073043 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6818788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D003110 Colonic Neoplasms Aspirin 3.0012411196
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8420501625
MESH:D015179 Colorectal Neoplasms Aspirin 2.8417047198
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.8116823706 16780908 11298694
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.374309450 9327722 15968718 2869522 19336974 16177239 7120509 7440962 15998439 21278145 11566570 19085960 17522070 15027814 3786805 7179309 6623471 16227642 3732212 10915739 10092053 6884620
MESH:D056486 Drug-Induced Liver Injury Selenium 12.3715131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.3715131321
MESH:D056486 Drug-Induced Liver Injury Tetracycline 12.3717522070
MESH:D004487 Edema Aspirin 4.0017259670
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver arsenic trioxide 13.9315073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.9312631006 16239168 19224547 15959796 61145 17595544 12795759 16045604
MESH:D005234 Fatty Liver Tetracycline 13.9319224547 16917069
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005909 Glioblastoma Aspirin 4.0212870263
MESH:D006261 Headache Aspirin 5.1315240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure Selenium 3.1417162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D015658 HIV Infections 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone 8.3917631934
MESH:D015658 HIV Infections deferasirox 8.3917631934
MESH:D012001 Hyperacusis Aspirin 5.9415240983
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.3414714311
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.0616705839
MESH:D007938 Leukemia arsenic trioxide 2.8815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1519850784 16968895 16467208 20471514 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2817217047 15748426 11468182 19075265 17649720 16966277 12712474 11161223 19035177 15336539 19642359 17869043 9834237 15622746 16891316 19225113 15213294 16331271 16823087 12679006 17107899 16330433 12018890 16112521 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616239168 11903743 17334410 11408273 17174718 16943688 16221502 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7511481614 18251166 17766677 17805973 20821823 15338365 16192424 14512876 18277467 18006644 12609069 18418968 18481824 12898905 18205269 18156304 16011737 18395914 18166357 17714472 14716833 17640975 15057751 15673190 15362042 17557913 16097048 14620537 18429990 13678700 17900296 12445418 18339082 17708605 18187930 15370692 18395095 12389079 18420326 12445421 18317297 12546737 17944888 15876570 16638106 15925388 17631135 17525996 15052691 12667390 17976157 17823541 16116963 12632514 17565644 17761835 16136751 15730626 18472094 12649538 15650968 16015684 12586293 17698563 18279442 12958196 18472332 12666154 15893842 16248980 18263696 18412020 16033810 15818738 14724832 18210741 15996030 18376398 17869086 18054572 15959796 14716496 17481882 16027843 15931870 12741479 10355542 14748882 12632512 17721639 17922224 15123356 18705752
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016246199 17285989 15720792 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.6714682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6721137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6719294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2112014681 15583823
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.4411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4418816296 18569708 20064080 18520028 20869020 17053015 20135361 20464547 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D008881 Migraine Disorders Aspirin 4.1415240983
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1811468182 14977855 19549372 15949261 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2016105982 16882451
MESH:D009203 Myocardial Infarction Aspirin 3.5912692751
MESH:D009325 Nausea Aspirin 5.3915240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009369 Neoplasms 4-phenylbutyric acid 5.6419116145
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6411141357
MESH:D009395 Nephritis, Interstitial Tetracycline 4.969884423
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1810525206
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5312819281 16049721
MESH:D010003 Osteoarthritis Aspirin 4.127009135
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4416624393 12452020 19769630
MESH:D010146 Pain Aspirin 3.946363464 6995502
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.6111026799
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.6911156591
MESH:D020795 Photophobia Aspirin 5.9415240983
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D017096 Prion Diseases Tetracycline 5.5710903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.5419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5418760546
MESH:D012220 Rhinitis Aspirin 4.4812372130
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.4012269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3917007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.392093021 20155912
MESH:D020521 Stroke Aspirin 4.4616403987
MESH:D013927 Thrombosis Aspirin 4.6117672075
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.5211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5217053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Aspirin 4.5510982225 20485159
Pathway ID Pathway Name
REACT:216 DNA Repair
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
REACT:1675 mRNA Processing
REACT:769 Pausing and recovery of elongation
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
REACT:12472 Regulatory RNA pathways
KEGG:03020 RNA polymerase
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33507
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA164745534dienestrol
    PA451581tamoxifen
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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