AutismKB 2.0

Annotation Detail for POLR2B


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Basic Information Top
Gene Symbol:POLR2B ( POL2RB,RPB2,hRPB140,hsRPB2 )
Gene Full Name: polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Band: 4q12
Quick LinksEntrez ID:5431; OMIM: 180661; Uniprot ID:RPB2_HUMAN; ENSEMBL ID: ENSG00000047315; HGNC ID: 9188
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa03020RNA polymerase
hsa00230Purine metabolism
hsa05016Huntington's disease
hsa01100Metabolic pathways
Pathway IDPathway Name
Elongation arrest and recovery
Regulatory RNA pathways
Pausing and recovery of elongation
Transcription
DNA Repair
mRNA Processing
Gene Expression
HIV Infection
No data
No data
Pathway IDPathway Name
500949RNA Polymerase II Pre-transcription Events
500366MicroRNA (miRNA) Biogenesis
500065Formation of transcription-coupled NER (TC-NER) repair complex
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
head and neck cancer lung cancer
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of POLR2B mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of POLR2B mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of POLR2B mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of POLR2B mRNAaffects expression 17562736
D004958 Estradiol Estradiol results in increased expression of POLR2B mRNAincreases expression 16514628
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR2B mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in decreased expression of POLR2B mRNAdecreases expression 16514628
D007657 Ketone Bodies Ketone Bodies results in increased expression of POLR2B mRNAincreases expression 16807920
D020849 Raloxifene Raloxifene results in decreased expression of POLR2B mRNAdecreases expression 16514628
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POLR2B mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000419 Albuminuria Raloxifene 4.8317308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001284 Atrophy fulvestrant 5.0911514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001930 Brain Injuries Raloxifene 4.7316580743
MESH:D001943 Breast Neoplasms Estradiol 2.0214630087 17289903 18497071 12948864 16675129 17261762 17018787 19861407
MESH:D001943 Breast Neoplasms fulvestrant 2.0218984771
MESH:D001943 Breast Neoplasms Raloxifene 2.0215775269 17893378 17242785 17049068 17595753 17440819 17261762 15758505 17952589 15572757 16837676 16912660
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.663084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6616924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5815775269
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.126135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0217110522 16105132 17681005 15861022 17333356 16919318 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 12621046 15340226 16354765 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.8815800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3417474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.6219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.6217451421 15920148 17308373
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4211461765 17906064 19923254 14986274 12153990 19420014 12705907 10915739 12540782 11421492 11739529 16177239 14550746 15619225 19370779 17522070 19416960 16081117 18713872 11834606 19164858 19085960 11743745 16781746 10774834 12392966 16485898 19739265 10663392 16227642 18071297 12958197 2444490 11287661 16393943 16109766 12594235 15968718 11529661 14725611 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Raloxifene 7.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.9212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.9215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.2119148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.2111473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5515345470
MESH:D005234 Fatty Liver Raloxifene 8.5517473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6711110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Raloxifene 5.4517577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3617937319
MESH:D007248 Infertility, Male fulvestrant 7.3611514358
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 6.2515629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.2515618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms Estradiol 7.9415610895
MESH:D007889 Leiomyoma Raloxifene 4.7216973256
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19784758 12587719 12969438 19014921 16610002 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.597678174
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.142876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6817203775 11408345 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5816497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D009232 Myxoma Raloxifene 5.8716343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009421 Nervous System Malformations Estradiol 10.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D010024 Osteoporosis Raloxifene 3.5115775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4517823083 17893378 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2916740699
MESH:D011471 Prostatic Neoplasms Raloxifene 3.2915731164 16220300 16536755
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011693 Purpura Raloxifene 5.8715770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D020521 Stroke Raloxifene 3.9816837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013978 Tibial Fractures Estradiol 14.8019048282
MESH:D013978 Tibial Fractures Raloxifene 14.8019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4416049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.4417572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.5316837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8716343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:216 DNA Repair
REACT:1892 Elongation arrest and recovery
REACT:71 Gene Expression
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
KEGG:01100 Metabolic pathways
REACT:1675 mRNA Processing
REACT:769 Pausing and recovery of elongation
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
REACT:12472 Regulatory RNA pathways
KEGG:03020 RNA polymerase
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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