AutismKB 2.0

Annotation Detail for GNG2


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Basic Information Top
Gene Symbol:GNG2 ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), gamma 2
Band: 14q22.1
Quick LinksEntrez ID:54331; OMIM: 606981; Uniprot ID:GBG2_HUMAN; ENSEMBL ID: ENSG00000186469; HGNC ID: 4404
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Transmembrane transport of small molecules
Hemostasis
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200019Signaling events mediated by HDAC Class II
200083CXCR4-mediated signaling events
200145Nongenotropic Androgen signaling
200069Thromboxane A2 receptor signaling
200090Rapid glucocorticoid signaling
200150CXCR3-mediated signaling events
200011LPA receptor mediated events
200147Hedgehog signaling events mediated by Gli proteins
200029Plasma membrane estrogen receptor signaling
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P05730Endogenous cannabinoid signaling
P04386Histamine H2 receptor mediated signaling pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of GNG2 mRNAdecreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GNG2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GNG2 mRNAaffects expression 17562736
D001464 Barium [GNB1 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB2 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB3 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB4 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB5 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D009020 Morphine Morphine results in increased expression of GNG2 mRNAincreases expression 15183518
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.6311289319 1440618
MESH:D002545 Brain Ischemia Morphine 5.6819211983
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.943581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.997505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.282524372 8156756 11906362 18759878 11298694 12868966 8970840 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D003967 Diarrhea Morphine 4.962540324
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9918648102 18289764 7440962 18692083 9328219 1440618 9022650 6482804 8291058 11289319 16192314 6679447 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9912705907 11834606 18713872 12594235 10663392 16781746 2444490 11421492 19370779 19416960 17562736 16109766 14550746 11287661 10774834 16227642 12540782 16081117 19923254 12958197 19420014 19164858 11529661 10915739 12153990 16177239 16393943 14725611 11743745 15968718 12392966 19739265 11739529 18071297 16485898 17906064 15619225 17522070 14986274 19085960 11461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6919014921 16611625 19784758 12587719 12969438 16610002 11587558 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.73598648 3712494 1399818 6587162
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.774026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010146 Pain Acetaminophen 8.0816870215
MESH:D010146 Pain Morphine 8.0816273134 15215642 6776300 15275824 20225289 18699797
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D015427 Reperfusion Injury Morphine 4.2819211983
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.156582329 3712494 7505956 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.398074119
MESH:D014581 Urticaria Acetaminophen 3.3810982225
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28784
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01159 other/unknown Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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