AutismKB 2.0

Annotation Detail for CYTL1


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Basic Information Top
Gene Symbol:CYTL1 ( C17,C4orf4 )
Gene Full Name: cytokine-like 1
Band: 4p16.2
Quick LinksEntrez ID:54360; OMIM: 607930; Uniprot ID:CYTL1_HUMAN; ENSEMBL ID: ENSG00000170891; HGNC ID: 24435
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter]affects binding|decreases reaction 15761015
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CYTL1 mRNAdecreases expression 15761015
15070760
D004041 Dietary Fats Dietary Fats results in increased expression of CYTL1 mRNAincreases expression 18042831
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of CYTL1 mRNAdecreases expression 15761015
C041786 palm oil palm oil results in increased expression of CYTL1 mRNAincreases expression 18042831
D017382 Reactive Oxygen Species Reactive Oxygen Species affects the expression of CYTL1 mRNAaffects expression 15761015
D014212 Tretinoin Tretinoin results in decreased expression of CYTL1 mRNAdecreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3419825857 11798837
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.2716206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2716206674 16197459
MESH:D001943 Breast Neoplasms Dietary Fats 2.1720435547
MESH:D001943 Breast Neoplasms Tretinoin 2.1716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1911135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.191917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616051514 16096774
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.7216936243
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.1510525206
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 4.1515736158
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.1517551590 14991402 16925845 9664655 10589399 9142499 8800419 9125849 9211117 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3016569247
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005124 Eye Abnormalities Tretinoin 3.819664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 8.9915073043
MESH:D005234 Fatty Liver Dietary Fats 8.9918296743 19551842 17967931 19004024
MESH:D005355 Fibrosis Dietary Fats 10.2618296743
MESH:D005355 Fibrosis Tretinoin 10.2617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005909 Glioblastoma Tretinoin 3.1917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 3.3011836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 5.1819381132
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.6016518626
MESH:D007938 Leukemia arsenic trioxide 6.8015070760
MESH:D007938 Leukemia Tretinoin 6.8017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.5819077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.5816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0317050201 16467208 20471514 16968895 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 8.2819075265 16966277 16112521 16330433 16823087 19225113 17107899 12018890 9834237 17217047 19035177 17649720 11468182 11161223 19642359 12679006 16331271 17869043 17712046 15213294 15336539 15622746 12712474 16891316 15748426
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2817506722 19642359 15748426 16140955 19075265 17339181 17301526 17107899 19225113 17217047 16766008 9834237 12679006 19035177 16788101 16891316 17368321 17649720 16935935 16823087 19029980 17294898 16331271 17361223 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0318296743
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4314682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Reactive Oxygen Species 3.9017992120
MESH:D008545 Melanoma Tretinoin 3.9016752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219417148 11468182 14977855 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9317596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009369 Neoplasms Tretinoin 2.5416594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.169125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9510525206
MESH:D009436 Neural Tube Defects Tretinoin 7.959142499
MESH:D009765 Obesity Dietary Fats 2.3420132043 20518802 18457598 21332399 16723640 17217161 18674790 19632207 11836018
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1416624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1416936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 9.3415580305
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 9.3415580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 9.3415976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.5012065085
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.3712065085
MESH:D012878 Skin Neoplasms Tretinoin 6.3716467112
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.5217007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.5217261132
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 8.0217045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5812845720 20435036 12973940 11780464
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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