AutismKB 2.0

Annotation Detail for NLGN3


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Basic Information Top
Gene Symbol:NLGN3 ( HNL3,KIAA1480 )
Gene Full Name: neuroligin 3
Band: Xq13.1
Quick LinksEntrez ID:54413; OMIM: 300336; Uniprot ID:NLGN3_HUMAN; ENSEMBL ID: ENSG00000196338; HGNC ID: 14289
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04514Cell adhesion molecules (CAMs)
No data
No data
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Related Diseases/Disorders Top
No data
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Desease Name
Autism, susceptibility to, X-linked-1
Asperger syndrome, susceptibility to, X-linked-1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NLGN3 mRNAaffects expression 16483693
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of NLGN3 geneincreases mutagenesis 16495775
D005419 Flavonoids Flavonoids results in decreased expression of NLGN3 mRNAdecreases expression 18035473
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D000236 Adenoma Ethylnitrosourea 3.946695378
OMIM:300494 ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 1 marker/mechanism
OMIM:300425 AUTISM, SUSCEPTIBILITY TO, X-LINKED 1 marker/mechanism
MESH:D001321 Autistic Disorder marker/mechanism 12669065 18621663
MESH:D001927 Brain Diseases Ethylnitrosourea 5.3314991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.7416436596 16357521 18412241 15144691 16651633
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 4.0116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.8517160924
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.8518357618
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1016436596
MESH:D005910 Glioma Ethylnitrosourea 3.6316651633 16357521 18412241
MESH:D007249 Inflammation Flavonoids 2.8417296493
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.3217379185
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316271038 6695378 17703301 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.2515790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.7015375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7710838139 10767621 18041768
MESH:D008579 Meningioma Ethylnitrosourea 6.8517943659
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 5.0516707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.1616651423 16003739 17160924
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.8517160924
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.9015790496
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31649
    • No data
    Releated disease ID Related disease Name
    PA447198Autistic Disorder
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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