AutismKB 2.0

Annotation Detail for DNAJC10


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DNAJC10 ( DKFZp434J1813,ERdj5,JPDI,MGC104194 )
Gene Full Name: DnaJ (Hsp40) homolog, subfamily C, member 10
Band: 2q32.1
Quick LinksEntrez ID:54431; OMIM: 607987; Uniprot ID:DJC10_HUMAN; ENSEMBL ID: ENSG00000077232; HGNC ID: 24637
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04141Protein processing in endoplasmic reticulum
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of DNAJC10 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DNAJC10 proteinaffects expression 20106945
D001205 Ascorbic Acid Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of DNAJC10 mRNA]decreases reaction|increases expression 17353921
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DNAJC10 mRNAdecreases expression 20018196
D003010 Clorgyline Clorgyline results in increased expression of DNAJC10 mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in increased expression of DNAJC10 mRNAincreases expression 20106945
D017313 Fenretinide Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of DNAJC10 mRNA]decreases reaction|increases expression 17353921
D017313 Fenretinide Fenretinide results in increased expression of DNAJC10 mRNAincreases expression 17353921
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DNAJC10 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of DNAJC10 mRNAdecreases expression 17426115
C031280 pyrazole pyrazole results in increased expression of DNAJC10 mRNAincreases expression 17945193
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DNAJC10 mRNAdecreases expression 17101203
D019284 Thapsigargin Thapsigargin results in increased expression of DNAJC10 mRNAincreases expression 17353921
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Fenretinide 3.1410697514
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001932 Brain Neoplasms Fenretinide 4.4816187019
MESH:D001943 Breast Neoplasms Ascorbic Acid 2.0716443354
MESH:D001943 Breast Neoplasms Fenretinide 2.0716601279
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8312907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 4.8317159502 16270382
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 3.2116274795
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.696135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6912371664
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.6716154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 16354765 12621046 8697196
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D003139 Common Cold Ascorbic Acid 5.6917323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 4.6516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6517107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5318551238 21346803
MESH:D056486 Drug-Induced Liver Injury pyrazole 6.5312499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:C538011 Eales disease Ascorbic Acid 5.699068938
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Cyclosporine 9.0712168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.0720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Fenretinide 3.9816187019
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 7.0816080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8516120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.5116490937 16863852
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2615340226 8697196 16354765 16959395 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 5.1010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1018850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007972 Leukoplakia, Oral Fenretinide 6.2616707609
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.077678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.079163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 11.0715890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.862876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.868603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 14.8618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8612151625
MESH:D008171 Lung Diseases Ascorbic Acid 4.0416863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5914755239
MESH:D008175 Lung Neoplasms Ascorbic Acid 3.5916401635
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6510697514
MESH:D008545 Melanoma Fenretinide 2.8416270382
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Fenretinide 4.4216274795
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009369 Neoplasms therapeutic 17353921
MESH:D009369 Neoplasms Fenretinide 5.4517353921 15958647
MESH:D009369 Neoplasms pirinixic acid 5.4517405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.8716303764
MESH:D009765 Obesity Ascorbic Acid 4.8517217161
MESH:D009765 Obesity pirinixic acid 4.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D010051 Ovarian Neoplasms Fenretinide 3.2716133793
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.3915580305
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Clorgyline 3.9319691856
MESH:D011471 Prostatic Neoplasms Fenretinide 3.9317024972
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.5514606601
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration Fenretinide 4.5016303925
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.3416849425
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Ascorbic Acid 3.2418709164
MESH:D012878 Skin Neoplasms Fenretinide 6.0916467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0916192470
MESH:D013276 Stomach Ulcer Ascorbic Acid 4.0318726076
MESH:D020521 Stroke Ascorbic Acid 4.4016517955 16403987
MESH:D013733 Testicular Diseases pyrazole 5.016499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5516049721
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 5.5516720286
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 4.6916154183
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:04141 Protein processing in endoplasmic reticulum
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved