AutismKB 2.0

Annotation Detail for SSH1


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Basic Information Top
Gene Symbol:SSH1 ( FLJ21928,FLJ38102,KIAA1298,SSH1L )
Gene Full Name: slingshot homolog 1 (Drosophila)
Band: 12q24.11
Quick LinksEntrez ID:54434; OMIM: 606778; Uniprot ID:SSH1_HUMAN; ENSEMBL ID: ENSG00000084112; HGNC ID: 30579
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
No data
Pathway IDPathway Name
200189FGF signaling pathway
200083CXCR4-mediated signaling events
Pathway IDPathway Name
P00016Cytoskeletal regulation by Rho GTPase
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of SSH1 mRNAaffects expression 18414638
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SSH1 mRNAdecreases expression 19150397
20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SSH1 mRNAaffects expression 17484886
D002117 Calcitriol Calcitriol results in increased expression of SSH1 mRNAincreases expression 16002434
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SSH1 mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of SSH1 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of SSH1 mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D000419 Albuminuria Raloxifene 4.9217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D020261 Arsenic Poisoning Arsenic 2.9316835338 12569548 16251483 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4019371607 12928151
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001930 Brain Injuries Raloxifene 4.8316580743
MESH:D001943 Breast Neoplasms Calcitriol 2.0011237771
MESH:D001943 Breast Neoplasms Raloxifene 2.0015758505 16912660 17261762 17893378 15775269 17242785 17440819 15572757 17049068 17595753 17952589 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 2.0019115204 19244106 20544844 16818667 19011961 17242785 21152245 16202921 19084267 11161223 19189212 19059307 19189210 16873071 19221464 19142967 20859285 20390343 19200415 19289846 15565566 16273361 17440819 19155303 18815881 18425577 15668708 18351453 17893378 19103187 21138602 19410462 19487384 20005174 18821012 18997820 17049068 18855134 19288272 20135344 18629630 20065188 17261762 19066611 18984771
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1415721981 16192424 16227642 16050911 15673190 16097048 3786805 16124888 15700767 18705752 10355542 16011737
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7315504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.8517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.8518788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8516924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.1515504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1511237771
MESH:D002295 Carcinoma, Transitional Cell Arsenic 17.5218640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 17.5217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 17.5217572228
MESH:D002318 Cardiovascular Diseases Arsenic 8.1717938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases Raloxifene 8.1715775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.5616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9020889678
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003072 Cognition Disorders Raloxifene 4.9815800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003928 Diabetic Nephropathies Raloxifene 9.8717308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.8719279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.106884620 21278145 10092053 9327722 7120509 6623471 3786805 10915739 3732212 7440962 19336974 17522070 2869522 16227642 15027814 4309450 7179309 19085960 16177239 11566570 15998439 15968718
MESH:D004487 Edema pirinixic acid 7.8412083418
MESH:D004487 Edema Raloxifene 7.8415860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 17.4615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.4615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.4619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 16202921 20544844 17893378
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.2661145 12795759 19224547 15959796 17595544 12631006 16045604 16239168
MESH:D005234 Fatty Liver pirinixic acid 21.2620131406 19236843
MESH:D005234 Fatty Liver Raloxifene 21.2617473493
MESH:D005234 Fatty Liver Tamoxifen 21.2619224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D006331 Heart Diseases Raloxifene 3.7211110106
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 18467677 19176532 19772884
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 5.889931084 11953799 16076760
MESH:D006973 Hypertension Raloxifene 5.8817577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007642 Keratosis Arsenic 5.3912749816 16930632
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007889 Leiomyoma Raloxifene 4.8016973256
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9411408273 17157831 16239168 16221502 21278145 16943688 17334410 11903743 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6017766677 18210741 18420326 12445418 12632512 20821823 15996030 17944888 13678700 14620537 15123356 12389079 12586293 11481614 17631135 17714472 15730626 17823541 10355542 16015684 18339082 18395914 16192424 15931870 18205269 15057751 12445421 17976157 12632514 18054572 18418968 16116963 18263696 17698563 18429990 18006644 15959796 17805973 12741479 16097048 17761835 14716496 17708605 18481824 14716833 12898905 15876570 15893842 12609069 17565644 16027843 18412020 18187930 17869086 18279442 18472332 18395095 16638106 17721639 15338365 12958196 18251166 17640975 17481882 15362042 17900296 15673190 18317297 18156304 18705752 17525996 12546737 16248980 14748882 12667390 16011737 14512876 12666154 14724832 18376398 15650968 16136751 15370692 17557913 18277467 15052691 17922224 15925388 18472094 16033810 15818738 18166357 12649538
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.6018564211
MESH:D008107 Liver Diseases Arsenic 4.4311134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.4316964402 16246199 15720792 15830285 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9514706259 16899240
MESH:D008113 Liver Neoplasms Arsenic 11.4716368122
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.4719294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.4715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 11.4716684651
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7715583823 12014681
MESH:D008175 Lung Neoplasms Arsenic 2.6717976673 19168569 17306315
MESH:D008175 Lung Neoplasms Tamoxifen 2.6718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0015863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009232 Myxoma Raloxifene 6.0016343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419200415 19189210 19196722
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010024 Osteoporosis Raloxifene 3.5515775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5317823083 15579764 15758505 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3916905509 15371236 6392382
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms Arsenic 2.0916140617
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0916644109 16289102 12479363 18247401 15754350
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0916536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0915067354
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D011693 Purpura Raloxifene 6.0015770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012871 Skin Diseases Arsenic 2.8016759981 17548696 18709164 17050553 16353154 15952646 19834688 17453740 6392382 17938729 16702368
MESH:D012878 Skin Neoplasms Arsenic 3.1219538983 17050553 17976673 16251483 15504454 17029826
MESH:D013088 Spermatocele Tamoxifen 4.7416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D020521 Stroke Raloxifene 4.0416837676
MESH:D013978 Tibial Fractures Raloxifene 5.6519048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.9718640142 17306315 17976673 11144890 19429237 15987713 19322015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.9717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.9717572228 8653321 16712894
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.6516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0016343187
Pathway ID Pathway Name
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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