AutismKB 2.0

Annotation Detail for GFOD1


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Basic Information Top
Gene Symbol:GFOD1 ( - )
Gene Full Name: glucose-fructose oxidoreductase domain containing 1
Band: 6p24.1-p23
Quick LinksEntrez ID:54438; OMIM: NA; Uniprot ID:GFOD1_HUMAN; ENSEMBL ID: ENSG00000145990; HGNC ID: 21096
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
CHEMDEPENDENCY
smoking cessation
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GFOD1 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of GFOD1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GFOD1 mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A results in decreased expression of GFOD1 mRNAdecreases expression 20678512
D016572 Cyclosporine Cyclosporine results in decreased expression of GFOD1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of GFOD1 mRNAincreases expression 18042831
C011890 kojic acid kojic acid results in decreased expression of GFOD1 mRNAdecreases expression 16595896
C041786 palm oil palm oil results in increased expression of GFOD1 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GFOD1 mRNAdecreases expression 19933214
D014810 Vitamin E Vitamin E results in increased expression of GFOD1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 16354765 15340226 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5219769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7019416960 19164858 11461765 18713872 18071297 12153990 16781746 10774834 14725611 10663392 15968718 17562736 19739265 19420014 11421492 11529661 17522070 2444490 17906064 12392966 12705907 19923254 12958197 19370779 11287661 15619225 16177239 11739529 16227642 16485898 11834606 16393943 16081117 12594235 19085960 11743745 14986274 12540782 16109766 14550746 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 8.3119224547
MESH:D005234 Fatty Liver Dietary Fats 8.3117967931 19004024 19551842 18296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 16.0312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.0318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5910048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 11.5916080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7621332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007249 Inflammation Dietary Fats 5.1920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1912878042 12200463
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007333 Insulin Resistance bisphenol A 7.8516393666
MESH:D007333 Insulin Resistance Dietary Fats 7.8518457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3816169303
MESH:D008107 Liver Diseases Acetaminophen 1.6619460945 16610002 19784758 12587719 19014921 16611625 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5220195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5216984957
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.3618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3612151625
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4520064080 18816296 20869020 18569708 6695378 20464547 18520028 17053015 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4511884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.4511062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 10.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 2.3218674790 20518802 20132043 21332399 19632207 17217161 18457598 16723640 11836018
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.3110548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3111118676 11222880 11896295 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5416740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2317053015
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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