Annotation Detail for PON1
Basic Information Top
| Gene Symbol: | PON1 ( ESA,MVCD5,PON ) |
|---|---|
| Gene Full Name: | paraoxonase 1 |
| Band: | 7q21.3 |
| Quick Links | Entrez ID:5444; OMIM: 168820; Uniprot ID:PON1_HUMAN; ENSEMBL ID: ENSG00000005421; HGNC ID: 9204 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1902 | Kidney failure |
| 1904 | Diabetes mellitus |
| 1918 | Atherosclerosis |
| 2069 | Schizophrenia |
| 2178 | Retinal disease |
| Desease Name |
|---|
| hypercholesterolemia |
| Macular Degeneration |
| hyperglycemia hypertension, pregnancy induced preterm delivery |
| cardiovascular disease |
| Parkinson's disease |
| cholesterol, HDL |
| myocardial infarct stroke, ischemic |
| AGING |
| Atherosclerosis |
| glucose |
| NORMALVARIATION |
| atherosclerosis, coronary |
| atherosclerosis, coronary cholesterol, HDL triglycerides |
| cerebral infarct |
| C-reactive protein |
| Carotid Artery Diseases |
| CARDIOVASCULAR |
| Coronary Artery Disease |
| myocardial infarct |
| diabetes, type 1 |
| cholesterol, LDL |
| prostate cancer |
| coronary artery spasm |
| paraoxonase |
| glucose response |
| Alzheimer's disease |
| heart disease, ischemic |
| abdominal aortic aneurysm homocysteine hypertension |
| CANCER |
| PSYCH |
| stroke, ischemic |
| carotid artery damage |
| paraoxinase 1 activity |
| PHARMACOGENOMIC |
| lipids |
| response to TNF antagonist treatment |
| paraoxonase-1 |
| bone density |
| nephropathy in other diseases |
| RENAL |
| breast cancer |
| vascular disease |
| hypertension |
| pesticide toxicity |
| childhood brain tumor |
| lipoprotein, LDL |
| Coronary Stenosis |
| carotid intima-media thickness |
| Amyotrophic Lateral Sclerosis |
| beta-cell function |
| cardiovascular |
| IMMUNE |
| chronic symptoms in pesticide-exposed workers |
| NEUROLOGICAL |
| non-Hodgkin's lymphoma |
| body mass paraoxonase activity polycystic ovary syndrome |
| glaucoma, primary open-angle |
| nephropathy, IgA |
| schizophrenia |
| glomerulosclerosis, focal |
| METABOLIC |
| albumin excretion rate |
| organophosphate toxicity |
| Stroke |
| Myocardial Infarction |
| acetylcholinesterase |
| VISION |
| preterm delivery |
| fasting total cholesterol and LDL-cholesterol concentrations only |
| triglycerides |
| Multiple Chemical Sensitivity |
| lipid concentrations |
| Alzheimer's Disease/Coronary artery disease |
| increased serum glucose concentrations |
| HDL-cholesterol level |
| insulin |
| plasma lipoproteins |
| retinopathy, diabetic |
| cholesterol, total |
| coronary heart disease |
| ALS/amyotrophic lateral sclerosis |
| more degree of homeostasis model assessment IR |
| REPRODUCTION |
| diabetes, type 2 |
| Hepatitis C, Chronic |
| bone mineral density (BMD) |
| intima media thickness |
| longevity |
| Crohn's disease ulcerative colitis |
| carotid atherosclerosis |
| INFECTION |
| osteonecrosis |
| oxidative stress |
| Insulin Resistance |
| Desease Name |
|---|
| Response to TNF antagonist treatment |
| Desease Name |
|---|
| Microvascular complications of diabetes, susceptibility to, 5 |
| Coronary artery disease, susceptibility to |
| Coronary artery spasm 2, susceptibility to |
| Organophosphate poisoning, sensitivity to |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| C015153 | 1,2-dilauroylphosphatidylcholine | 1,2-dilauroylphosphatidylcholine results in increased activity of PON1 protein | increases activity | 12963475 |
| C051388 | 1,2-dioleoyl-sn-glycero-3-phosphoglycerol | 1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| C051388 | 1,2-dioleoyl-sn-glycero-3-phosphoglycerol | [Calcium co-treated with 1,2-dioleoyl-sn-glycero-3-phosphoglycerol] results in increased stability of PON1 protein | affects cotreatment|increases stability | 12871208 |
| C017251 | 1,2-oleoylphosphatidylcholine | 1,2-oleoylphosphatidylcholine inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| C016403 | 2,4-dinitrotoluene | 2,4-dinitrotoluene affects the expression of PON1 mRNA | affects expression | 21346803 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C027576 | 4-hydroxy-2-nonenal | 4-hydroxy-2-nonenal results in decreased activity of PON1 protein | decreases activity | 15375178 |
| C030601 | 4-hydroxymercuribenzoate | 4-hydroxymercuribenzoate results in decreased activity of PON1 protein | decreases activity | 12871208 |
| C030601 | 4-hydroxymercuribenzoate | Calcium promotes the reaction [Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein]] | decreases activity|decreases reaction|increases reaction | 12871208 |
| C030601 | 4-hydroxymercuribenzoate | Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 12871208 |
| C024836 | 4-nitrophenol | PON1 protein results in increased chemical synthesis of 4-nitrophenol | increases chemical synthesis | 16175651 |
| C047651 | 5-hydroxyeicosatetraenoic acid lactone | PON1 protein affects the metabolism of 5-hydroxyeicosatetraenoic acid lactone | affects metabolic processing | 15772423 12963475 |
| C047651 | 5-hydroxyeicosatetraenoic acid lactone | PON1 protein affects the metabolism of 5-hydroxyeicosatetraenoic acid lactone | affects metabolic processing | 12963475 |
| C047651 | 5-hydroxyeicosatetraenoic acid lactone | PON1 protein affects the metabolism of 5-hydroxyeicosatetraenoic acid lactone | affects metabolic processing | 12963475 |
| C003001 | 7-ketocholesterol | 7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15169886 |
| C003001 | 7-ketocholesterol | 7-ketocholesterol inhibits the reaction [Quercetin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15169886 |
| C003001 | 7-ketocholesterol | 7-ketocholesterol inhibits the reaction [resveratrol results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15458977 |
| C046938 | 9,11-linoleic acid | 9,11-linoleic acid results in increased activity of PON1 protein | increases activity | 15778275 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of PON1 mRNA | affects expression | 17562736 |
| D000082 | Acetaminophen | Acetaminophen affects the expression of PON1 protein | affects expression | 16099942 |
| D016604 | Aflatoxin B1 | Aflatoxin B1 affects the expression of PON1 protein | affects expression | 20106945 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of PON1 mRNA | affects expression | 16483693 |
| D000667 | Ampicillin | Ampicillin results in decreased activity of PON1 protein | decreases activity | 16880604 |
| D000667 | Ampicillin | Ampicillin results in decreased activity of PON1 protein | decreases activity | 16880604 |
| C432165 | anthra(1,9-cd)pyrazol-6(2H)-one | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA] | decreases expression|decreases reaction | 16269825 |
| C432165 | anthra(1,9-cd)pyrazol-6(2H)-one | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [FGF19 protein results in decreased expression of PON1 mRNA] | decreases expression|decreases reaction | 16269825 |
| C432165 | anthra(1,9-cd)pyrazol-6(2H)-one | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] | decreases expression|decreases reaction | 16269825 |
| D016718 | Arachidonic Acid | Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D016718 | Arachidonic Acid | Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| D016718 | Arachidonic Acid | Arachidonic Acid results in decreased activity of PON1 protein | decreases activity | 15375178 |
| D001151 | Arsenic | PON1 gene SNP affects the susceptibility to Arsenic | affects response to substance | 19152805 |
| D001151 | Arsenic | PON1 protein affects the susceptibility to Arsenic | affects response to substance | 19371607 |
| D001205 | Ascorbic Acid | 1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D001205 | Ascorbic Acid | 1,2-oleoylphosphatidylcholine inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 15375178 12871208 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D001205 | Ascorbic Acid | [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 15375178 12871208 |
| D001205 | Ascorbic Acid | Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] | affects cotreatment|decreases expression|decreases reaction | 16052486 |
| D001205 | Ascorbic Acid | erucic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D001205 | Ascorbic Acid | [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 16052486 |
| D001205 | Ascorbic Acid | [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 16052486 |
| D001205 | Ascorbic Acid | Oleic Acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D001205 | Ascorbic Acid | palmitoleic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D001205 | Ascorbic Acid | [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 16052486 |
| D001205 | Ascorbic Acid | [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 16052486 |
| C065179 | atorvastatin | atorvastatin results in increased activity of PON1 protein | increases activity | 15969877 15324535 |
| C065179 | atorvastatin | atorvastatin results in increased expression of PON1 mRNA | increases expression | 15690306 |
| C065179 | atorvastatin | PON1 gene polymorphism affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| C065179 | atorvastatin | PON1 gene SNP affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| C065179 | atorvastatin | PON1 protein affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in decreased expression of PON1 mRNA | decreases expression | 20106945 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of PON1 mRNA | increases expression | 15169886 |
| C095105 | bexarotene | bexarotene results in decreased expression of PON1 mRNA | decreases expression | 16648578 |
| D002084 | Butylated Hydroxytoluene | Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] | affects cotreatment|decreases expression|decreases reaction | 16052486 |
| D002118 | Calcium | [Calcium co-treated with 1,2-dioleoyl-sn-glycero-3-phosphoglycerol] results in increased stability of PON1 protein | affects cotreatment|increases stability | 12871208 |
| D002118 | Calcium | [Calcium co-treated with Oleic Acid] results in increased stability of PON1 protein | affects cotreatment|increases stability | 12871208 |
| D002118 | Calcium | Calcium promotes the reaction [Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein]] | decreases activity|decreases reaction|increases reaction | 12871208 |
| D002122 | Calcium Chloride | Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | increases hydrolysis|increases reaction | 16052486 |
| D002251 | Carbon Tetrachloride | Carbon Tetrachloride affects the expression of PON1 mRNA | affects expression | 12734012 |
| D002635 | Chenodeoxycholic Acid | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of PON1 mRNA] | decreases expression|decreases reaction | 16269825 |
| D002635 | Chenodeoxycholic Acid | Chenodeoxycholic Acid results in decreased expression of PON1 mRNA | decreases expression | 16269825 |
| D004390 | Chlorpyrifos | PON1 protein affects the metabolism of Chlorpyrifos | affects metabolic processing | 16002382 |
| D004390 | Chlorpyrifos | PON1 protein polymorphism results in increased susceptibility to Chlorpyrifos | increases response to substance | 16007003 |
| D004390 | Chlorpyrifos | PON1 protein results in increased hydrolysis of Chlorpyrifos | increases hydrolysis | 16331452 |
| D002784 | Cholesterol | PON1 protein results in decreased chemical synthesis of Cholesterol | decreases chemical synthesis | 12615663 |
| D002784 | Cholesterol | PON1 protein results in increased export of Cholesterol | increases export | 16229851 16331452 |
| D002784 | Cholesterol | Cholesterol results in decreased activity of PON1 protein | decreases activity | 16115471 |
| D002784 | Cholesterol | PON1 protein results in decreased chemical synthesis of Cholesterol | decreases chemical synthesis | 12615663 |
| D008076 | Cholesterol, HDL | Cholesterol, HDL results in increased activity of PON1 protein | increases activity | 16128586 |
| D008076 | Cholesterol, HDL | PON1 gene polymorphism affects the abundance of Cholesterol, HDL | affects abundance | 9699900 16030523 |
| D008076 | Cholesterol, HDL | PON1 gene polymorphism affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 gene polymorphism affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 gene SNP affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 gene SNP affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 protein affects the reaction [atorvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 protein affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D008076 | Cholesterol, HDL | PON1 protein binds to [APOA1 protein binds to Cholesterol, HDL] | affects binding | 16128586 |
| D008078 | Cholesterol, LDL | PON1 gene polymorphism affects the abundance of Cholesterol, LDL | affects abundance | 10952224 |
| D019826 | Cholic Acid | Cholic Acid results in decreased expression of PON1 mRNA | decreases expression | 16269825 |
| D019826 | Cholic Acid | Cholic Acid results in decreased expression of PON1 protein | decreases expression | 16269825 |
| D002939 | Ciprofloxacin | Ciprofloxacin results in decreased activity of PON1 protein | decreases activity | 16880604 |
| D002939 | Ciprofloxacin | Ciprofloxacin results in decreased activity of PON1 protein | decreases activity | 16880604 |
| C007084 | clindamycin-2-phosphate | clindamycin-2-phosphate results in decreased activity of PON1 protein | decreases activity | 16880604 |
| C007084 | clindamycin-2-phosphate | clindamycin-2-phosphate results in decreased activity of PON1 protein | decreases activity | 16880604 |
| D002995 | Clofibric Acid | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PON1 mRNA | affects cotreatment|affects expression | 17602206 |
| D003300 | Copper | Copper results in decreased activity of PON1 protein | decreases activity | 16112460 |
| D019327 | Copper Sulfate | 1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D019327 | Copper Sulfate | 1,2-oleoylphosphatidylcholine inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D019327 | Copper Sulfate | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D019327 | Copper Sulfate | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D019327 | Copper Sulfate | [Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 15375178 12871208 |
| D019327 | Copper Sulfate | erucic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D019327 | Copper Sulfate | Oleic Acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D019327 | Copper Sulfate | palmitoleic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of PON1 mRNA | decreases expression | 20106945 |
| C109757 | decan-4-olide | PON1 protein results in increased hydrolysis of decan-4-olide | increases hydrolysis | 15829432 |
| D017135 | Desogestrel | [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein | affects activity|affects cotreatment | 17541152 |
| D003976 | Diazinon | PON1 protein affects the metabolism of Diazinon | affects metabolic processing | 16027737 16002382 |
| D003976 | Diazinon | PON1 protein affects the susceptibility to Diazinon | affects response to substance | 15864126 |
| D003976 | Diazinon | PON1 protein results in increased hydrolysis of Diazinon | increases hydrolysis | 16331452 |
| C000912 | diazoxon | PON1 gene polymorphism affects the hydrolysis of diazoxon | affects hydrolysis | 10898114 |
| C000912 | diazoxon | PON1 gene polymorphism results in decreased hydrolysis of diazoxon | decreases hydrolysis | 12563177 |
| C000912 | diazoxon | PON1 protein results in increased hydrolysis of diazoxon | increases hydrolysis | 12563177 10898114 |
| D004052 | Diethylnitrosamine | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PON1 mRNA | affects cotreatment|affects expression | 17602206 |
| D004052 | Diethylnitrosamine | [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 20935162 |
| D004281 | Docosahexaenoic Acids | PON1 protein affects the metabolism of Docosahexaenoic Acids analog | affects metabolic processing | 15772423 |
| D004492 | Edetic Acid | Edetic Acid results in decreased activity of PON1 protein | decreases activity | 12963475 |
| C049811 | erucic acid | erucic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D004958 | Estradiol | Estradiol results in decreased expression of PON1 mRNA | decreases expression | 20106945 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with Desogestrel] affects the activity of PON1 protein | affects activity|affects cotreatment | 17541152 |
| D004997 | Ethinyl Estradiol | [Ethinyl Estradiol co-treated with Levonorgestrel] affects the activity of PON1 protein | affects activity|affects cotreatment | 17541152 |
| D004997 | Ethinyl Estradiol | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PON1 mRNA | affects cotreatment|increases expression | 17942748 |
| C442659 | ethinyl estradiol-desogestrel combination | ethinyl estradiol-desogestrel combination affects the activity of PON1 protein | affects activity | 17541152 |
| C004808 | farnesyl pyrophosphate | farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| C004808 | farnesyl pyrophosphate | farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| D005229 | Fatty Acids, Monounsaturated | Fatty Acids, Monounsaturated results in increased activity of PON1 protein | increases activity | 16276071 |
| D011345 | Fenofibrate | Fenofibrate results in increased expression of PON1 protein | increases expression | 16123850 |
| C020748 | ferrous sulfate | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| C020748 | ferrous sulfate | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| C020748 | ferrous sulfate | [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 12871208 15375178 |
| C043562 | flavone | flavone results in increased expression of PON1 mRNA | increases expression | 15169886 |
| C065180 | fluvastatin | fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 14668577 |
| C065180 | fluvastatin | fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 14668577 |
| C065180 | fluvastatin | fluvastatin results in decreased activity of PON1 protein | decreases activity | 14668577 |
| C056933 | fumonisin B1 | fumonisin B1 results in decreased expression of PON1 mRNA | decreases expression | 16221962 |
| C039281 | furan | furan results in decreased expression of PON1 mRNA | decreases expression | 15120968 |
| C002963 | geranylgeranyl pyrophosphate | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| C412815 | GW 4064 | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [GW 4064 results in decreased expression of PON1 mRNA] | decreases expression|decreases reaction | 16269825 |
| C412815 | GW 4064 | GW 4064 results in decreased expression of PON1 mRNA | decreases expression | 16269825 |
| C029424 | hydrazine | hydrazine results in decreased expression of PON1 mRNA | decreases expression | 15370871 |
| C029424 | hydrazine | hydrazine results in decreased expression of PON1 protein | decreases expression | 15370871 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| D006861 | Hydrogen Peroxide | Hydrogen Peroxide results in decreased activity of PON1 protein | decreases activity | 15375178 12871208 |
| D006861 | Hydrogen Peroxide | Oleic Acid inhibits the reaction [Hydrogen Peroxide results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 12871208 |
| D006880 | Hydroxy Acids | PON1 protein affects the metabolism of Hydroxy Acids | affects metabolic processing | 12963475 |
| D006880 | Hydroxy Acids | PON1 protein affects the metabolism of Hydroxy Acids | affects metabolic processing | 12963475 |
| D006997 | Hypochlorous Acid | Hypochlorous Acid results in decreased activity of PON1 protein | decreases activity | 14671042 |
| D007306 | Insecticides | PON1 gene polymorphism affects the susceptibility to Insecticides | affects response to substance | 12930676 |
| D007306 | Insecticides | PON1 protein affects the metabolism of Insecticides | affects metabolic processing | 16002382 16027737 |
| D007306 | Insecticides | PON1 protein results in increased hydrolysis of Insecticides | increases hydrolysis | 16331452 |
| D007306 | Insecticides | PON1 protein affects the metabolism of and results in decreased activity of Insecticides | affects metabolic processing|decreases activity | 16343727 |
| D007306 | Insecticides | PON1 protein results in increased hydrolysis of Insecticides | increases hydrolysis | 16353344 |
| D007501 | Iron | Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] | affects cotreatment|decreases expression|decreases reaction | 16052486 |
| D007501 | Iron | [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 16052486 |
| D007501 | Iron | [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 16052486 |
| D007501 | Iron | [Iron co-treated with Ascorbic Acid] results in decreased activity of PON1 protein | affects cotreatment|decreases activity | 16052486 |
| D007501 | Iron | [Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 16052486 |
| D007783 | Lactones | PON1 protein results in increased hydrolysis of Lactones | increases hydrolysis | 12963475 |
| D007854 | Lead | Lead results in decreased activity of PON1 protein | decreases activity | 16882531 |
| D007854 | Lead | PON1 gene mutant form results in increased susceptibility to Lead | increases response to substance | 16882531 |
| C026223 | lysophosphatidylglycerol | lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| C026223 | lysophosphatidylglycerol | lysophosphatidylglycerol results in decreased activity of PON1 protein | decreases activity | 15375178 |
| C025449 | lysophosphatidylinositol | lysophosphatidylinositol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| C025449 | lysophosphatidylinositol | lysophosphatidylinositol results in decreased activity of PON1 protein | decreases activity | 15375178 |
| D008713 | Methimazole | Methimazole results in increased activity of PON1 protein | increases activity | 14678291 |
| D008727 | Methotrexate | Methotrexate results in decreased expression of PON1 mRNA | decreases expression | 15120968 |
| D008748 | Methylcholanthrene | 7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15169886 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased activity of PON1 protein | increases activity | 15169886 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of PON1 mRNA | increases expression | 15169886 |
| D008748 | Methylcholanthrene | Methylcholanthrene results in increased expression of PON1 protein | increases expression | 11551529 |
| D008798 | Mevalonic Acid | Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| D008798 | Mevalonic Acid | Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] | affects binding|decreases reaction|increases reaction | 14500290 |
| D008798 | Mevalonic Acid | Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| C003297 | nandrolone decanoate | nandrolone decanoate results in decreased activity of PON1 protein | decreases activity | 16153628 |
| C005273 | naringenin | naringenin results in increased expression of PON1 mRNA | increases expression | 15169886 |
| D016912 | Levonorgestrel | [Ethinyl Estradiol co-treated with Levonorgestrel] affects the activity of PON1 protein | affects activity|affects cotreatment | 17541152 |
| D009768 | Obidoxime Chloride | PON1 protein results in increased hydrolysis of Obidoxime Chloride metabolite | increases hydrolysis | 15876422 |
| D019787 | Linoleic Acid | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D019787 | Linoleic Acid | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| D019787 | Linoleic Acid | Linoleic Acid results in decreased activity of PON1 protein | decreases activity | 15375178 12871208 |
| D019301 | Oleic Acid | [Calcium co-treated with Oleic Acid] results in increased stability of PON1 protein | affects cotreatment|increases stability | 12871208 |
| D019301 | Oleic Acid | Calcium promotes the reaction [Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein]] | decreases activity|decreases reaction|increases reaction | 12871208 |
| D019301 | Oleic Acid | Oleic Acid inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 12871208 |
| D019301 | Oleic Acid | Oleic Acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| D019301 | Oleic Acid | Oleic Acid inhibits the reaction [Hydrogen Peroxide results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 12871208 |
| D019301 | Oleic Acid | Oleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D019301 | Oleic Acid | Oleic Acid results in decreased activity of PON1 protein | decreases activity | 15375178 |
| C042763 | olive oil | olive oil results in increased activity of PON1 protein | increases activity | 16216721 |
| C405603 | Omacor | Omacor results in increased expression of PON1 protein | increases expression | 14767865 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | PON1 protein polymorphism results in increased susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | increases response to substance | 16007003 |
| C009618 | O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | PON1 protein affects the metabolism of and results in decreased activity of O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate | affects metabolic processing|decreases activity | 16343727 |
| D009943 | Organophosphorus Compounds | PON1 protein affects the metabolism of Organophosphorus Compounds | affects metabolic processing | 15982977 |
| C055122 | orlistat | orlistat results in increased activity of PON1 protein | increases activity | 17134960 |
| D010100 | Oxygen | Oxygen promotes the reaction [PON1 protein affects the metabolism of Paraoxon] | affects metabolic processing|increases reaction | 16391483 |
| D010100 | Oxygen | Oxygen results in increased activity of PON1 protein | increases activity | 16391483 |
| D010126 | Ozone | Ozone results in decreased expression of PON1 mRNA | decreases expression | 12763052 |
| C008757 | palmitoleic acid | palmitoleic acid inhibits the reaction [[Ascorbic Acid co-treated with Copper Sulfate] results in decreased activity of PON1 protein] | affects cotreatment|decreases activity|decreases reaction | 12871208 |
| C008757 | palmitoleic acid | palmitoleic acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| C008757 | palmitoleic acid | palmitoleic acid results in decreased activity of PON1 protein | decreases activity | 15375178 |
| D010261 | Paraoxon | 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | Calcium Chloride promotes the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | increases hydrolysis|increases reaction | 16052486 |
| D010261 | Paraoxon | Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | lysophosphatidylinositol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | Oleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | Oxygen promotes the reaction [PON1 protein affects the metabolism of Paraoxon] | affects metabolic processing|increases reaction | 16391483 |
| D010261 | Paraoxon | palmitoleic acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | PON1 protein affects the metabolism of Paraoxon | affects metabolic processing | 11304470 16175651 16079929 |
| D010261 | Paraoxon | PON1 protein results in increased hydrolysis of Paraoxon | increases hydrolysis | 15375178 16331452 16052486 16055108 9746266 |
| D010261 | Paraoxon | Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D010261 | Paraoxon | fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 14668577 |
| D010261 | Paraoxon | PON1 protein results in increased hydrolysis of Paraoxon | increases hydrolysis | 16052486 14668577 |
| D010278 | Parathion | PON1 gene mutant form results in increased metabolism of Parathion | increases metabolic processing | 12625227 |
| D010278 | Parathion | PON1 protein results in increased hydrolysis of Parathion | increases hydrolysis | 16331452 |
| C023036 | perfluorooctanoic acid | perfluorooctanoic acid results in decreased expression of PON1 mRNA | decreases expression | 17681415 |
| D010575 | Pesticides | PON1 gene polymorphism affects the susceptibility to Pesticides | affects response to substance | 15922524 16105444 |
| D010634 | Phenobarbital | [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of PON1 protein | affects cotreatment|decreases expression | 20935162 |
| C025136 | phenylacetic acid | 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | Arachidonic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | [Ascorbic Acid co-treated with Copper Sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | affects cotreatment|decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | Hydrogen Peroxide inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | PON1 promoter SNP results in decreased hydrolysis of phenylacetic acid | decreases hydrolysis | 16117861 |
| C025136 | phenylacetic acid | PON1 protein affects the metabolism of phenylacetic acid | affects metabolic processing | 11304470 16079929 |
| C025136 | phenylacetic acid | PON1 protein results in increased hydrolysis of phenylacetic acid | increases hydrolysis | 9746266 16052486 15375178 16117861 |
| C025136 | phenylacetic acid | Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| C025136 | phenylacetic acid | fluvastatin inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 14668577 |
| C025136 | phenylacetic acid | PON1 protein results in increased hydrolysis of phenylacetic acid | increases hydrolysis | 14668577 16052486 |
| D010672 | Phenytoin | Phenytoin results in decreased expression of PON1 mRNA | decreases expression | 15136057 |
| D010755 | Phosphoric Acid Esters | PON1 gene polymorphism affects the metabolism of and affects the activity of Phosphoric Acid Esters | affects activity|affects metabolic processing | 12928148 |
| D010755 | Phosphoric Acid Esters | PON1 protein results in increased hydrolysis of Phosphoric Acid Esters | increases hydrolysis | 15772423 16331452 |
| D010755 | Phosphoric Acid Esters | PON1 protein results in increased metabolism of and results in decreased activity of Phosphoric Acid Esters | decreases activity|increases metabolic processing | 10677395 |
| D010755 | Phosphoric Acid Esters | PON1 protein results in increased metabolism of Phosphoric Acid Esters | increases metabolic processing | 10470002 |
| D010755 | Phosphoric Acid Esters | PON1 protein affects the metabolism of Phosphoric Acid Esters | affects metabolic processing | 16353344 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PON1 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| C006253 | pirinixic acid | pirinixic acid results in decreased expression of PON1 mRNA | decreases expression | 16221962 |
| C108475 | pitavastatin | farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| C108475 | pitavastatin | Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| C108475 | pitavastatin | pitavastatin results in increased expression of PON1 mRNA | increases expression | 15690306 |
| C108475 | pitavastatin | Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| D010938 | Plant Oils | Plant Oils results in increased activity of PON1 protein | increases activity | 16216721 |
| D028321 | Plant Preparations | Plant Preparations results in increased activity of PON1 protein | increases activity | 15158307 |
| D008926 | Plicamycin | Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15690306 |
| D011084 | Polycyclic Hydrocarbons, Aromatic | PON1 gene polymorphism results in increased susceptibility to Polycyclic Hydrocarbons, Aromatic | increases response to substance | 16323636 |
| D011441 | Propylthiouracil | Propylthiouracil results in decreased activity of PON1 protein | decreases activity | 15386442 |
| D011441 | Propylthiouracil | Vitamin E inhibits the reaction [Propylthiouracil results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 15386442 |
| D011765 | Pyruvaldehyde | Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] | decreases reaction|increases hydrolysis | 15375178 |
| D011765 | Pyruvaldehyde | Pyruvaldehyde inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] | decreases reaction|increases hydrolysis | 15375178 |
| D011765 | Pyruvaldehyde | Pyruvaldehyde results in decreased activity of PON1 protein | decreases activity | 15375178 |
| D011794 | Quercetin | 7-ketocholesterol inhibits the reaction [Quercetin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15169886 |
| D011794 | Quercetin | Quercetin promotes the reaction [AHR protein binds to PON1 promoter] | affects binding|increases reaction | 15169886 |
| D011794 | Quercetin | Quercetin results in increased activity of PON1 protein | increases activity | 15169886 |
| D011794 | Quercetin | Quercetin results in increased expression of PON1 mRNA | increases expression | 15169886 |
| D011794 | Quercetin | Quercetin results in increased activity of PON1 protein | increases activity | 19141295 |
| D011794 | Quercetin | Quercetin results in increased expression of PON1 mRNA | increases expression | 19141295 |
| D017382 | Reactive Oxygen Species | Reactive Oxygen Species results in decreased activity of PON1 protein | decreases activity | 16055108 |
| C059514 | resveratrol | 7-ketocholesterol inhibits the reaction [resveratrol results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 15458977 |
| C059514 | resveratrol | AHR protein promotes the reaction [resveratrol results in increased expression of PON1 mRNA] | increases expression|increases reaction | 15458977 |
| C059514 | resveratrol | resveratrol results in increased activity of PON1 protein | increases activity | 15458977 |
| C059514 | resveratrol | resveratrol results in increased expression of and results in increased activity of PON1 protein | increases activity|increases expression | 17879943 |
| C059514 | resveratrol | resveratrol results in increased expression of PON1 mRNA | increases expression | 15458977 |
| D012524 | Sarin | PON1 protein results in increased hydrolysis of Sarin | increases hydrolysis | 16331452 |
| D019821 | Simvastatin | farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| D019821 | Simvastatin | geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| D019821 | Simvastatin | Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] | affects binding|decreases reaction|increases reaction | 14500290 |
| D019821 | Simvastatin | Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| D019821 | Simvastatin | PON1 gene polymorphism affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D019821 | Simvastatin | PON1 gene SNP affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D019821 | Simvastatin | PON1 protein affects the reaction [Simvastatin results in increased abundance of Cholesterol, HDL] | affects reaction|increases abundance | 16238680 |
| D019821 | Simvastatin | Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter] | affects binding|increases reaction | 14500290 |
| D019821 | Simvastatin | Simvastatin results in increased expression of and results in increased activity of PON1 protein | increases activity|increases expression | 14500290 |
| D019821 | Simvastatin | Simvastatin results in increased expression of PON1 mRNA | increases expression | 15690306 14500290 |
| D019821 | Simvastatin | Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| C017947 | sodium arsenite | sodium arsenite results in decreased expression of PON1 mRNA | decreases expression | 17350061 |
| D018038 | Sodium Selenite | Sodium Selenite results in decreased expression of PON1 mRNA | decreases expression | 18175754 |
| D012999 | Soman | PON1 protein results in increased hydrolysis of Soman | increases hydrolysis | 16331452 |
| D012999 | Soman | PON1 protein results in decreased susceptibility to Soman | decreases response to substance | 15707963 |
| D012999 | Soman | PON1 protein results in increased hydrolysis of Soman | increases hydrolysis | 15707963 |
| D013185 | Squalene | Squalene inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] | decreases reaction|increases expression | 14500290 |
| D013656 | Taurocholic Acid | FGFR4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA] | affects reaction|decreases expression | 16284190 |
| D013656 | Taurocholic Acid | NR1H4 protein affects the reaction [Taurocholic Acid results in decreased expression of PON1 mRNA] | affects reaction|decreases expression | 16284190 |
| D013656 | Taurocholic Acid | Taurocholic Acid results in decreased expression of PON1 mRNA | decreases expression | 16284190 |
| C001803 | tempol | tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 15829432 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in decreased expression of PON1 mRNA | decreases expression | 20106945 |
| D013749 | Tetrachlorodibenzodioxin | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PON1 mRNA | affects cotreatment|increases expression | 17942748 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin results in increased expression of PON1 mRNA | increases expression | 16960034 |
| D014280 | Triglycerides | PON1 gene mutant form affects the abundance of Triglycerides | affects abundance | 14996478 |
| D014810 | Vitamin E | Vitamin E inhibits the reaction [Propylthiouracil results in decreased activity of PON1 protein] | decreases activity|decreases reaction | 15386442 |
| D014810 | Vitamin E | Vitamin E results in increased activity of PON1 protein | increases activity | 15386442 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000014 | Abnormalities, Drug-Induced | Methotrexate | 12.84 | 12039119 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Phenobarbital | 12.84 | 6195326 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Phenytoin | 12.84 | 10563481 3425630 6195326 9677735 9118846 8986270 | |
| MESH:D000014 | Abnormalities, Drug-Induced | Tetrachlorodibenzodioxin | 12.84 | 14514962 11752688 15322242 | |
| MESH:D000138 | Acidosis | Ammonium Chloride | 2.63 | 18287403 | |
| MESH:D000142 | Acidosis, Respiratory | Copper Sulfate | 5.47 | 7265320 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 2.99 | 17505938 | |
| MESH:D058186 | Acute Kidney Injury | resveratrol | 3.01 | 16538975 | |
| MESH:D055371 | Acute Lung Injury | Oxygen | 6.33 | 16759491 | |
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 6.33 | 18653653 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 4.86 | 20127859 20464547 | |
| MESH:D000230 | Adenocarcinoma | Estradiol | 4.86 | 11473722 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 4.86 | 14692618 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 10.75 | 6695378 | |
| MESH:D000236 | Adenoma | Diethylnitrosamine | 10.75 | 6695378 10737359 | |
| MESH:D000236 | Adenoma | Methylcholanthrene | 10.75 | 6695378 10545420 | |
| MESH:D000236 | Adenoma | resveratrol | 10.75 | 15688382 | |
| MESH:D018248 | Adenoma, Liver Cell | Diethylnitrosamine | 17.24 | 19061943 19052882 18056438 16434500 17620307 17162532 | |
| MESH:D018248 | Adenoma, Liver Cell | Phenobarbital | 17.24 | 17620307 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 17.24 | 16434500 | |
| MESH:D018248 | Adenoma, Liver Cell | Tetrachlorodibenzodioxin | 17.24 | 16835633 | |
| MESH:D000310 | Adrenal Gland Neoplasms | sodium arsenite | 3.74 | 15276417 | |
| MESH:D018246 | Adrenocortical Adenoma | Arsenic | 10.62 | 17306315 | |
| MESH:D018246 | Adrenocortical Adenoma | sodium arsenite | 10.62 | 16712894 17306315 | |
| MESH:D000382 | Agricultural Workers' Diseases | marker/mechanism | 15982977 | ||
| MESH:D000382 | Agricultural Workers' Diseases | Chlorpyrifos | 13.06 | 11874814 16611668 17119214 | |
| MESH:D000382 | Agricultural Workers' Diseases | Diazinon | 13.06 | 16487989 | |
| MESH:D000382 | Agricultural Workers' Diseases | Parathion | 13.06 | 11874814 17119214 | |
| MESH:D000382 | Agricultural Workers' Diseases | Pesticides | 13.06 | 17119214 | |
| MESH:D019896 | alpha 1-Antitrypsin Deficiency | Iron | 4.71 | 16640825 | |
| MESH:D000544 | Alzheimer Disease | Copper | 6.66 | 16962711 16325427 16886094 17119284 16410023 16866297 | |
| MESH:D000544 | Alzheimer Disease | Iron | 6.66 | 16563566 16640825 | |
| MESH:D000544 | Alzheimer Disease | Ozone | 6.66 | 15513908 | |
| MESH:D000544 | Alzheimer Disease | resveratrol | 6.66 | 16162502 16183991 | |
| MESH:D000690 | Amyotrophic Lateral Sclerosis | 4-hydroxy-2-nonenal | 6.29 | 10965797 | |
| MESH:D000690 | Amyotrophic Lateral Sclerosis | Copper | 6.29 | 10694572 | |
| MESH:D000740 | Anemia | Iron | 6.15 | 16434484 16566752 | |
| MESH:D000740 | Anemia | Tetrachlorodibenzodioxin | 6.15 | 11748828 | |
| MESH:D000743 | Anemia, Hemolytic | Quercetin | 3.38 | 17084956 | |
| MESH:D018798 | Anemia, Iron-Deficiency | Copper | 7.68 | 16614410 | |
| MESH:D018798 | Anemia, Iron-Deficiency | Iron | 7.68 | 17162259 17375513 16569441 17163184 17147795 | |
| MESH:D000756 | Anemia, Sideroblastic | Iron | 3.95 | 16910769 | |
| MESH:D000799 | Angioedema | Acetaminophen | 2.89 | 10982225 | |
| MESH:D000860 | Anoxia | Copper Sulfate | 13.65 | 7265320 | |
| MESH:D000860 | Anoxia | Oleic Acid | 13.65 | 15090967 | |
| MESH:D000860 | Anoxia | Oxygen | 13.65 | 20872349 | |
| MESH:D000881 | Anthrax | Ciprofloxacin | 5.75 | 20385868 | |
| MESH:D016736 | Antiphospholipid Syndrome | Ciprofloxacin | 5.75 | 9485080 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 3.15 | 19183758 | |
| MESH:D001145 | Arrhythmias, Cardiac | Iron | 3.54 | 16604332 | |
| MESH:D020261 | Arsenic Poisoning | Arsenic | 2.50 | 16251483 18414634 16835338 12569548 | |
| MESH:D001161 | Arteriosclerosis | 9,11-linoleic acid | 7.68 | 15778275 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 7.68 | 11256880 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 5.14 | 15885639 | |
| MESH:D001169 | Arthritis, Experimental | resveratrol | 5.14 | 17115116 | |
| MESH:D001172 | Arthritis, Rheumatoid | marker/mechanism | 16055108 | ||
| MESH:D001172 | Arthritis, Rheumatoid | Methotrexate | 3.83 | 17286800 | |
| MESH:D001172 | Arthritis, Rheumatoid | Ozone | 3.83 | 15570426 | |
| MESH:D001249 | Asthma | Ozone | 2.28 | 16373670 17854713 | |
| MESH:D001260 | Ataxia Telangiectasia | Iron | 9.99 | 15336622 | |
| MESH:D001260 | Ataxia Telangiectasia | Quercetin | 9.99 | 15336622 | |
| MESH:D050197 | Atherosclerosis | marker/mechanism|therapeutic | 19371607 16216721 16229851 16331452 | ||
| MESH:D050197 | Atherosclerosis | 7-ketocholesterol | 37.79 | 16632123 | |
| MESH:D050197 | Atherosclerosis | Arsenic | 37.79 | 19371607 12928151 | |
| MESH:D050197 | Atherosclerosis | Cholesterol | 37.79 | 16632123 | |
| MESH:D050197 | Atherosclerosis | Iron | 37.79 | 16640825 16632123 | |
| MESH:D050197 | Atherosclerosis | Methylcholanthrene | 37.79 | 11922910 | |
| MESH:D050197 | Atherosclerosis | olive oil | 37.79 | 16216721 | |
| MESH:D050197 | Atherosclerosis | Oxygen | 37.79 | 16391483 | |
| MESH:D050197 | Atherosclerosis | Paraoxon | 37.79 | 16391483 | |
| MESH:D050197 | Atherosclerosis | Phenytoin | 37.79 | 15136057 | |
| MESH:D050197 | Atherosclerosis | Plant Oils | 37.79 | 16216721 | |
| MESH:D050197 | Atherosclerosis | resveratrol | 37.79 | 16873680 17967414 | |
| MESH:D001289 | Attention Deficit Disorder with Hyperactivity | Pesticides | 4.77 | 20478945 | |
| MESH:D001321 | Autistic Disorder | marker/mechanism | 16297937 16027737 | ||
| MESH:D001321 | Autistic Disorder | Acetaminophen | 3.41 | 18445737 | |
| MESH:D001321 | Autistic Disorder | Arachidonic Acid | 3.41 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Docosahexaenoic Acids | 3.41 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Iron | 3.41 | 17352947 | |
| MESH:D001321 | Autistic Disorder | Linoleic Acid | 3.41 | 18582451 | |
| MESH:D001321 | Autistic Disorder | Pesticides | 3.41 | 17938740 | |
| MESH:D001327 | Autoimmune Diseases | Quercetin | 3.49 | 19761891 | |
| MESH:D001424 | Bacterial Infections | Ciprofloxacin | 9.44 | 11505790 | |
| MESH:D001424 | Bacterial Infections | Iron | 9.44 | 16640825 | |
| MESH:D001480 | Basal Ganglia Diseases | Organophosphorus Compounds | 5.67 | 16804273 | |
| MESH:D001778 | Blood Coagulation Disorders | ferrous sulfate | 15.07 | 6421970 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 15.07 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Propylthiouracil | 15.07 | 19483382 | |
| MESH:D001778 | Blood Coagulation Disorders | Tetrachlorodibenzodioxin | 15.07 | 12125929 | |
| MESH:D001836 | Body Weight Changes | Tetrachlorodibenzodioxin | 2.84 | 15340226 | |
| MESH:D001848 | Bone Diseases, Developmental | Tetrachlorodibenzodioxin | 2.08 | 15746008 | |
| MESH:D002545 | Brain Ischemia | resveratrol | 3.35 | 17600658 | |
| MESH:D001932 | Brain Neoplasms | marker/mechanism | 16002382 | ||
| MESH:D001932 | Brain Neoplasms | Copper | 3.73 | 17079463 | |
| MESH:D001943 | Breast Neoplasms | Ascorbic Acid | 9.46 | 16443354 | |
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 9.46 | 17474063 20146248 | |
| MESH:D001943 | Breast Neoplasms | bexarotene | 9.46 | 16818667 16344269 | |
| MESH:D001943 | Breast Neoplasms | Copper | 9.46 | 15986119 17079463 | |
| MESH:D001943 | Breast Neoplasms | Diethylnitrosamine | 9.46 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Estradiol | 9.46 | 12948864 14630087 17289903 17018787 16675129 19861407 17261762 18497071 | |
| MESH:D001943 | Breast Neoplasms | Methotrexate | 9.46 | 16978400 | |
| MESH:D001943 | Breast Neoplasms | Methylcholanthrene | 9.46 | 17474063 | |
| MESH:D001943 | Breast Neoplasms | Oxygen | 9.46 | 17263869 | |
| MESH:D001943 | Breast Neoplasms | Parathion | 9.46 | 12762645 | |
| MESH:D001943 | Breast Neoplasms | Plant Preparations | 9.46 | 17398067 | |
| MESH:D001943 | Breast Neoplasms | Quercetin | 9.46 | 18628248 | |
| MESH:D001943 | Breast Neoplasms | resveratrol | 9.46 | 16393696 17651959 17534123 | |
| MESH:D001943 | Breast Neoplasms | Tetrachlorodibenzodioxin | 9.46 | 20435547 | |
| MESH:D016535 | Bronchial Hyperreactivity | Ozone | 2.90 | 18417511 19059883 15516495 18315731 16777450 14754758 17626835 | |
| MESH:D019121 | Burkholderia Infections | orlistat | 5.68 | 17874328 | |
| MESH:D002100 | Cachexia | Ozone | 3.80 | 16183385 | |
| MESH:D002105 | Cadmium Poisoning | Quercetin | 4.59 | 16962696 | |
| MESH:D002181 | Candidiasis, Vulvovaginal | Estradiol | 3.52 | 16111702 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Carbon Tetrachloride | 6.89 | 10355542 16227642 16192424 16050911 18705752 15673190 16097048 15700767 3786805 15721981 16011737 16124888 | |
| MESH:D002252 | Carbon Tetrachloride Poisoning | Vitamin E | 6.89 | 16050911 | |
| MESH:D002277 | Carcinoma | Methylcholanthrene | 5.74 | 10545420 | |
| MESH:D002277 | Carcinoma | Tetrachlorodibenzodioxin | 5.74 | 16835633 | |
| MESH:D002280 | Carcinoma, Basal Cell | Arsenic | 2.97 | 17687452 15504454 | |
| MESH:D006528 | Carcinoma, Hepatocellular | 2,4-dinitrotoluene | 22.14 | 16705839 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 22.14 | 3084413 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Aflatoxin B1 | 22.14 | 21507988 12619106 12907637 | |
| MESH:D006528 | Carcinoma, Hepatocellular | anthra(1,9-cd)pyrazol-6(2H)-one | 22.14 | 19418558 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Arsenic | 22.14 | 16507464 17306315 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Carbon Tetrachloride | 22.14 | 18788625 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Diethylnitrosamine | 22.14 | 10672840 19208518 20007298 20084675 20101231 20727157 19107877 19519916 16698587 16502159 20935162 11831363 16540662 3084413 21159647 19701751 19919837 16935385 18665156 19394651 16830150 19171122 10737359 18210153 19383236 17138121 18971187 19539802 16681979 20214788 19418558 16807293 17428255 18393292 18691550 18506893 18494052 16569478 19822196 17173139 16878318 17761372 3581430 19052882 19335982 18785209 17055752 17978847 20514400 20524982 18978308 16288022 20432363 16328049 18788625 17162532 20512989 16779866 18056438 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Estradiol | 22.14 | 16924424 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Phenobarbital | 22.14 | 17173139 20007298 20935162 6705139 1701930 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Quercetin | 22.14 | 12508355 19519916 | |
| MESH:D006528 | Carcinoma, Hepatocellular | resveratrol | 22.14 | 16227395 19321006 | |
| MESH:D006528 | Carcinoma, Hepatocellular | sodium arsenite | 22.14 | 15276417 16507464 17306315 | |
| MESH:D018827 | Carcinoma, Lewis Lung | resveratrol | 3.65 | 16675471 | |
| MESH:D002289 | Carcinoma, Non-Small-Cell Lung | bexarotene | 2.81 | 16247446 | |
| MESH:D021441 | Carcinoma, Pancreatic Ductal | Quercetin | 4.03 | 17234771 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Arsenic | 9.99 | 15504454 17687452 18922899 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 9.99 | 20419170 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Plant Preparations | 9.99 | 17418620 | |
| MESH:D002294 | Carcinoma, Squamous Cell | resveratrol | 9.99 | 16227395 | |
| MESH:D002294 | Carcinoma, Squamous Cell | sodium arsenite | 9.99 | 18572023 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Arsenic | 7.31 | 18640142 | |
| MESH:D002295 | Carcinoma, Transitional Cell | Ciprofloxacin | 7.31 | 15028437 10741713 | |
| MESH:D006332 | Cardiomegaly | atorvastatin | 11.31 | 18360054 | |
| MESH:D006332 | Cardiomegaly | Copper | 11.31 | 17327471 | |
| MESH:D006332 | Cardiomegaly | Quercetin | 11.31 | 19794523 | |
| MESH:D006332 | Cardiomegaly | Tetrachlorodibenzodioxin | 11.31 | 18670907 18850075 16120746 | |
| MESH:D009202 | Cardiomyopathies | Iron | 3.36 | 16640825 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Iron | 3.03 | 16604332 | |
| MESH:D002318 | Cardiovascular Diseases | marker/mechanism|therapeutic | 19152805 15169886 | ||
| MESH:D002318 | Cardiovascular Diseases | Arsenic | 15.23 | 15738583 17938729 19152805 | |
| MESH:D002318 | Cardiovascular Diseases | Hydrogen Peroxide | 15.23 | 16936243 | |
| MESH:D002318 | Cardiovascular Diseases | olive oil | 15.23 | 16216721 | |
| MESH:D002318 | Cardiovascular Diseases | Plant Preparations | 15.23 | 16862667 | |
| MESH:D002318 | Cardiovascular Diseases | resveratrol | 15.23 | 15458977 | |
| MESH:D002340 | Carotid Artery Diseases | Arsenic | 3.48 | 16973168 18022660 | |
| MESH:D016893 | Carotid Stenosis | Plant Preparations | 5.19 | 15158307 | |
| MESH:D002386 | Cataract | Acetaminophen | 5.64 | 10977129 | |
| MESH:D002386 | Cataract | Simvastatin | 5.64 | 12518039 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 13.59 | 12371664 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Diethylnitrosamine | 13.59 | 7505956 21159647 17174075 2727394 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Estradiol | 13.59 | 18566989 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Methylcholanthrene | 13.59 | 16192471 | |
| MESH:D002471 | Cell Transformation, Neoplastic | sodium arsenite | 13.59 | 20056578 19524636 | |
| MESH:D002493 | Central Nervous System Diseases | Phenobarbital | 8.62 | 4080065 | |
| MESH:D002493 | Central Nervous System Diseases | Phenytoin | 8.62 | 4080065 | |
| MESH:D018281 | Cholangiocarcinoma | Diethylnitrosamine | 6.59 | 19052882 | |
| MESH:D018281 | Cholangiocarcinoma | Tetrachlorodibenzodioxin | 6.59 | 16835633 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 13.16 | 19486331 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 13.16 | 16105132 11677210 16919318 17333356 17681005 17110522 15861022 | |
| MESH:D002779 | Cholestasis | Levonorgestrel | 13.16 | 15861022 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 13.16 | 19176532 | |
| OMIM:601042 | CHOREOATHETOSIS/SPASTICITY, EPISODIC | Phenytoin | 4.92 | 11748493 | |
| MESH:D019457 | Chromosome Breakage | Sodium Selenite | 3.83 | 15894690 | |
| MESH:D002916 | Chylothorax | orlistat | 5.68 | 17003701 | |
| MESH:D002971 | Cleft Lip | Phenytoin | 3.56 | 2227380 | |
| MESH:D002972 | Cleft Palate | Phenytoin | 4.45 | 2227380 3877104 6856622 6862529 1687470 10789828 | |
| MESH:D002972 | Cleft Palate | Tetrachlorodibenzodioxin | 4.45 | 12621046 16354765 15340226 8697196 15668235 | |
| MESH:D003092 | Colitis | resveratrol | 3.22 | 16474422 | |
| MESH:D003103 | Coloboma | Phenytoin | 4.29 | 9212184 | |
| MESH:D003110 | Colonic Neoplasms | Iron | 4.30 | 16640825 | |
| MESH:D003110 | Colonic Neoplasms | Quercetin | 4.30 | 17191121 16640504 19056647 11134977 15741050 19440933 17148506 | |
| MESH:D003110 | Colonic Neoplasms | resveratrol | 4.30 | 16338953 | |
| MESH:D015179 | Colorectal Neoplasms | Quercetin | 2.41 | 18852136 18095365 | |
| MESH:D015179 | Colorectal Neoplasms | resveratrol | 2.41 | 16550006 | |
| MESH:D003128 | Coma | Organophosphorus Compounds | 5.67 | 17098105 | |
| MESH:D003139 | Common Cold | Ascorbic Acid | 4.52 | 17323712 | |
| MESH:D000013 | Congenital Abnormalities | Phenytoin | 6.66 | 10627286 | |
| MESH:D000013 | Congenital Abnormalities | Tetrachlorodibenzodioxin | 6.66 | 14669216 17141729 | |
| MESH:D003324 | Coronary Artery Disease | marker/mechanism | |||
| MESH:D003324 | Coronary Artery Disease | atorvastatin | 5.39 | 16368305 | |
| MESH:D003324 | Coronary Artery Disease | Plant Preparations | 5.39 | 15158307 | |
| MESH:D003327 | Coronary Disease | marker/mechanism | 16882531 16353344 | ||
| MESH:D003327 | Coronary Disease | fluvastatin | 6.62 | 16142594 | |
| MESH:D003327 | Coronary Disease | resveratrol | 6.62 | 16507316 | |
| MESH:D003329 | Coronary Vasospasm | marker/mechanism | |||
| MESH:D019465 | Craniofacial Abnormalities | Lead | 6.94 | 19769572 | |
| MESH:D019465 | Craniofacial Abnormalities | Methotrexate | 6.94 | 9562676 12039119 | |
| MESH:D019465 | Craniofacial Abnormalities | Phenytoin | 6.94 | 9212184 19952982 8986270 | |
| MESH:D019465 | Craniofacial Abnormalities | Reactive Oxygen Species | 6.94 | 15736158 | |
| MESH:D019465 | Craniofacial Abnormalities | Tetrachlorodibenzodioxin | 6.94 | 20055451 10048152 15322242 | |
| MESH:D019465 | Craniofacial Abnormalities | Vitamin E | 6.94 | 19769572 | |
| MESH:D003490 | Cyanosis | 2,4-dinitrotoluene | 3.09 | 18551238 | |
| MESH:D003550 | Cystic Fibrosis | Ciprofloxacin | 13.71 | 19747007 | |
| MESH:D003550 | Cystic Fibrosis | Docosahexaenoic Acids | 13.71 | 19747007 | |
| MESH:D003550 | Cystic Fibrosis | Methotrexate | 13.71 | 19747007 | |
| MESH:D003550 | Cystic Fibrosis | Simvastatin | 13.71 | 19747007 | |
| MESH:D003704 | Dementia | Lead | 4.40 | 16140633 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 1.89 | 18249437 | |
| MESH:D003882 | Dermatomyositis | Methotrexate | 4.22 | 20191521 | |
| MESH:D048909 | Diabetes Complications | orlistat | 4.88 | 19207292 | |
| MESH:D003920 | Diabetes Mellitus | marker/mechanism | 16229851 | ||
| MESH:D003920 | Diabetes Mellitus | Iron | 6.75 | 16640825 16604332 | |
| MESH:D003920 | Diabetes Mellitus | Sodium Selenite | 6.75 | 16285004 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | Quercetin | 5.91 | 19496084 | |
| MESH:D003921 | Diabetes Mellitus, Experimental | resveratrol | 5.91 | 16873680 | |
| MESH:D003922 | Diabetes Mellitus, Type 1 | Iron | 2.97 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Ascorbic Acid | 7.28 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Diethylnitrosamine | 7.28 | 20387270 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Iron | 7.28 | 16506275 | |
| MESH:D003924 | Diabetes Mellitus, Type 2 | Tetrachlorodibenzodioxin | 7.28 | 17107852 | |
| MESH:D003928 | Diabetic Nephropathies | Estradiol | 6.30 | 19279558 | |
| MESH:D003928 | Diabetic Nephropathies | resveratrol | 6.30 | 16286809 | |
| MESH:D003930 | Diabetic Retinopathy | marker/mechanism | 20012460 | ||
| MESH:D003967 | Diarrhea | orlistat | 3.86 | 20002075 | |
| OMIM:607208 | DRAVET SYNDROME | Phenytoin | 4.47 | 11748493 | |
| MESH:D003875 | Drug Eruptions | Phenytoin | 4.58 | 15024534 | |
| MESH:D056486 | Drug-Induced Liver Injury | marker/mechanism | 16099942 | ||
| MESH:D056486 | Drug-Induced Liver Injury | 2,4-dinitrotoluene | 12.32 | 18551238 21346803 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 12.32 | 17562736 19739265 11529661 12958197 10663392 19085960 12540782 15968718 17522070 14725611 11421492 18713872 16485898 12705907 2444490 11743745 10774834 16177239 15619225 17906064 19370779 11739529 14550746 16781746 12392966 16109766 19164858 11461765 12153990 16227642 12594235 11834606 16393943 19416960 19420014 16081117 19923254 18071297 10915739 14986274 11287661 | |
| MESH:D056486 | Drug-Induced Liver Injury | Carbon Tetrachloride | 12.32 | 15027814 10915739 3732212 17522070 2869522 4309450 7179309 15968718 3786805 7440962 7120509 9327722 15998439 19085960 6623471 19336974 21278145 11566570 10092053 16177239 6884620 16227642 | |
| MESH:D056486 | Drug-Induced Liver Injury | Diethylnitrosamine | 12.32 | 19107877 | |
| MESH:D056486 | Drug-Induced Liver Injury | fumonisin B1 | 12.32 | 16221962 | |
| MESH:D056486 | Drug-Induced Liver Injury | Sodium Selenite | 12.32 | 15131321 | |
| MESH:D056486 | Drug-Induced Liver Injury | Tetrachlorodibenzodioxin | 12.32 | 20420201 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 3.14 | 19426721 | |
| MESH:D004362 | Drug Toxicity | Plant Preparations | 5.98 | 11033412 | |
| MESH:D004362 | Drug Toxicity | Tetrachlorodibenzodioxin | 5.98 | 11462148 | |
| MESH:D004381 | Duodenal Ulcer | Ampicillin | 5.11 | 10671773 | |
| MESH:D050171 | Dyslipidemias | Fenofibrate | 3.69 | 16707586 | |
| MESH:D004417 | Dyspnea | Diazinon | 7.60 | 16487989 | |
| MESH:D004417 | Dyspnea | Oxygen | 7.60 | 20016425 | |
| MESH:D004421 | Dystonia | Phenobarbital | 3.12 | 1851702 | |
| MESH:C538011 | Eales disease | Ascorbic Acid | 9.90 | 9068938 | |
| MESH:C538011 | Eales disease | Vitamin E | 9.90 | 9068938 | |
| MESH:D004487 | Edema | Arachidonic Acid | 12.82 | 9831321 16716910 7990266 15177302 9599246 11698051 | |
| MESH:D004487 | Edema | perfluorooctanoic acid | 12.82 | 12083418 17259670 | |
| MESH:D004487 | Edema | pirinixic acid | 12.82 | 12083418 | |
| MESH:D004487 | Edema | resveratrol | 12.82 | 8985016 | |
| MESH:D004487 | Edema | Tetrachlorodibenzodioxin | 12.82 | 12711302 11000095 | |
| MESH:D004489 | Edema, Cardiac | Tetrachlorodibenzodioxin | 2.95 | 16714409 18230668 15322242 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 10.35 | 12538720 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Phenytoin | 10.35 | 17654737 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | resveratrol | 10.35 | 17872969 | |
| MESH:D016889 | Endometrial Neoplasms | Estradiol | 5.48 | 18566989 19148513 11473722 | |
| MESH:D016889 | Endometrial Neoplasms | Fenofibrate | 5.48 | 16569247 | |
| MESH:D004715 | Endometriosis | Tetrachlorodibenzodioxin | 2.19 | 9294722 10568697 | |
| MESH:D020345 | Enterocolitis, Necrotizing | resveratrol | 3.93 | 17923197 | |
| MESH:D004816 | Epidermal Necrolysis, Toxic | Phenytoin | 4.30 | 20235791 | |
| MESH:D004820 | Epidermolysis Bullosa | Phenytoin | 5.27 | 6251365 1399206 | |
| MESH:D004831 | Epilepsies, Myoclonic | Phenobarbital | 3.19 | 3659116 | |
| MESH:D004828 | Epilepsies, Partial | Phenobarbital | 7.19 | 3922381 11558140 | |
| MESH:D004828 | Epilepsies, Partial | Phenytoin | 7.19 | 17116037 11558140 | |
| MESH:D004827 | Epilepsy | Phenobarbital | 5.07 | 20417680 | |
| MESH:D004827 | Epilepsy | Phenytoin | 5.07 | 20417680 821787 11434505 | |
| MESH:D004832 | Epilepsy, Absence | Phenobarbital | 2.73 | 6401628 | |
| MESH:D017029 | Epilepsy, Complex Partial | Phenobarbital | 8.62 | 7750514 | |
| MESH:D017029 | Epilepsy, Complex Partial | Phenytoin | 8.62 | 7750514 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Phenobarbital | 7.74 | 3659116 | |
| MESH:D004830 | Epilepsy, Tonic-Clonic | Phenytoin | 7.74 | 3659116 | |
| MESH:D004931 | Esophageal Achalasia | Diethylnitrosamine | 4.16 | 16302075 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 3.71 | 16530937 | |
| MESH:D004938 | Esophageal Neoplasms | Plant Preparations | 3.71 | 16510608 | |
| MESH:D020329 | Essential Tremor | Lead | 4.99 | 14594619 18007985 | |
| MESH:D005124 | Eye Abnormalities | Tetrachlorodibenzodioxin | 2.26 | 11564622 | |
| MESH:D005234 | Fatty Liver | Carbon Tetrachloride | 19.80 | 12631006 17595544 15959796 12795759 16239168 16045604 19224547 61145 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 19.80 | 19224547 | |
| MESH:D005234 | Fatty Liver | Diethylnitrosamine | 19.80 | 20387270 21071580 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 19.80 | 15345470 | |
| MESH:D005234 | Fatty Liver | Iron | 19.80 | 16640825 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 19.80 | 19236843 20131406 | |
| MESH:D005313 | Fetal Death | Phenytoin | 7.69 | 10627286 | |
| MESH:D005313 | Fetal Death | Tetrachlorodibenzodioxin | 7.69 | 11858732 | |
| MESH:D005317 | Fetal Growth Retardation | Lead | 4.64 | 19769572 | |
| MESH:D005334 | Fever | Arachidonic Acid | 3.83 | 11852909 | |
| MESH:D005354 | Fibrosarcoma | Methylcholanthrene | 4.00 | 14633661 10962813 | |
| MESH:D005355 | Fibrosis | Carbon Tetrachloride | 13.71 | 18705752 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 13.71 | 12168785 12639820 | |
| MESH:D005355 | Fibrosis | Quercetin | 13.71 | 19474275 | |
| MESH:D005355 | Fibrosis | Tetrachlorodibenzodioxin | 13.71 | 20067830 | |
| MESH:D005414 | Flatulence | orlistat | 5.68 | 20002075 | |
| MESH:D005534 | Foot Diseases | Arsenic | 4.60 | 6392382 | |
| MESH:D005621 | Friedreich Ataxia | Iron | 4.50 | 16640825 16604332 | |
| MESH:D005739 | Gas Poisoning | Oxygen | 4.26 | 20016425 | |
| MESH:D005756 | Gastritis | Acetaminophen | 2.72 | 16983495 | |
| MESH:D005833 | Genital Neoplasms, Female | sodium arsenite | 3.74 | 16452187 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 9.79 | 8708960 | |
| MESH:D005885 | Gingival Hyperplasia | Phenytoin | 9.79 | 9029455 | |
| MESH:D019214 | Gingival Overgrowth | Phenytoin | 5.27 | 14659971 16390469 | |
| MESH:D005909 | Glioblastoma | Quercetin | 2.73 | 19804834 | |
| MESH:D005910 | Glioma | Quercetin | 2.58 | 17643826 | |
| MESH:D015432 | Glomerulonephritis, Membranoproliferative | marker/mechanism | 16175651 | ||
| MESH:D006058 | Gonadal Disorders | Tetrachlorodibenzodioxin | 3.63 | 10696789 | |
| MESH:D006086 | Graft vs Host Disease | Methotrexate | 4.23 | 16518429 | |
| MESH:D006261 | Headache | Plant Oils | 5.22 | 19121572 | |
| MESH:D006330 | Heart Defects, Congenital | Ascorbic Acid | 11.05 | 16080930 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 11.05 | 20471113 | |
| MESH:D006330 | Heart Defects, Congenital | Tetrachlorodibenzodioxin | 11.05 | 11294989 10048152 | |
| MESH:D006330 | Heart Defects, Congenital | Vitamin E | 11.05 | 16080930 | |
| MESH:D006331 | Heart Diseases | Ciprofloxacin | 3.99 | 11505790 | |
| MESH:D006333 | Heart Failure | atorvastatin | 8.36 | 16360360 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 8.36 | 20558911 | |
| MESH:D006333 | Heart Failure | pitavastatin | 8.36 | 15502390 | |
| MESH:D016481 | Helicobacter Infections | Ciprofloxacin | 4.60 | 17643012 | |
| MESH:D006432 | Hemochromatosis | Iron | 3.75 | 16604332 16640825 17236123 17255318 16574947 17053826 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 3.48 | 15720958 | |
| MESH:D006470 | Hemorrhage | Tetrachlorodibenzodioxin | 2.48 | 11000095 | |
| MESH:D006486 | Hemosiderosis | Iron | 4.26 | 16604332 | |
| MESH:D006505 | Hepatitis | Carbon Tetrachloride | 6.65 | 19110552 19900420 | |
| MESH:D006505 | Hepatitis | Diazinon | 6.65 | 16487989 | |
| MESH:D006521 | Hepatitis, Chronic | Copper | 4.32 | 17338147 | |
| MESH:D006525 | Hepatitis, Viral, Human | Iron | 4.51 | 16640825 | |
| MESH:D006527 | Hepatolenticular Degeneration | Copper | 8.42 | 19888908 17182432 17109627 17276780 16607473 | |
| MESH:D006527 | Hepatolenticular Degeneration | Iron | 8.42 | 17182432 | |
| MESH:D006529 | Hepatomegaly | fumonisin B1 | 22.08 | 16221962 | |
| MESH:D006529 | Hepatomegaly | Iron | 22.08 | 16890145 | |
| MESH:D006529 | Hepatomegaly | perfluorooctanoic acid | 22.08 | 3609246 | |
| MESH:D006529 | Hepatomegaly | Phenobarbital | 22.08 | 16109766 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 22.08 | 19772884 16221962 19176532 18467677 | |
| MESH:D006529 | Hepatomegaly | Tetrachlorodibenzodioxin | 22.08 | 15340226 16120746 12621046 | |
| MESH:D006548 | Hernia, Diaphragmatic | Ascorbic Acid | 4.60 | 16490937 16863852 | |
| MESH:D006548 | Hernia, Diaphragmatic | Vitamin E | 4.60 | 16490937 16863852 | |
| MESH:D006558 | Herpes Genitalis | Estradiol | 4.07 | 15709030 | |
| MESH:D006561 | Herpes Simplex | resveratrol | 3.25 | 16876885 | |
| MESH:D015658 | HIV Infections | Iron | 3.10 | 16597321 | |
| MESH:D006689 | Hodgkin Disease | sodium arsenite | 2.38 | 12676792 | |
| MESH:D019584 | Hot Flashes | Estradiol | 6.90 | 17088409 | |
| MESH:D019584 | Hot Flashes | Vitamin E | 6.90 | 14716179 | |
| MESH:D006869 | Hydronephrosis | Tetrachlorodibenzodioxin | 3.09 | 18606429 15340226 16354765 8697196 16959395 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 5.28 | 16870215 | |
| MESH:D006930 | Hyperalgesia | perfluorooctanoic acid | 5.28 | 12083418 | |
| MESH:D006932 | Hyperbilirubinemia | Carbon Tetrachloride | 3.59 | 16899240 | |
| MESH:D006937 | Hypercholesterolemia | marker/mechanism | 16229851 | ||
| MESH:D006937 | Hypercholesterolemia | atorvastatin | 10.76 | 11583720 | |
| MESH:D006937 | Hypercholesterolemia | Cholesterol | 10.76 | 16933029 | |
| MESH:D006937 | Hypercholesterolemia | resveratrol | 10.76 | 17188708 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 6.46 | 20558911 | |
| MESH:D006943 | Hyperglycemia | Quercetin | 6.46 | 18262572 11834736 | |
| MESH:D020138 | Hyperhomocysteinemia | marker/mechanism | 17292331 | ||
| MESH:D020138 | Hyperhomocysteinemia | Phenytoin | 3.85 | 10459572 | |
| MESH:D017488 | Hyperkeratosis, Epidermolytic | Arsenic | 3.61 | 17050553 | |
| MESH:D006949 | Hyperlipidemias | orlistat | 6.93 | 21332399 | |
| MESH:D006949 | Hyperlipidemias | resveratrol | 6.93 | 16873680 | |
| MESH:D006951 | Hyperlipoproteinemias | marker/mechanism | 15324535 | ||
| MESH:D006938 | Hyperlipoproteinemia Type II | marker/mechanism | 16030523 16238680 | ||
| MESH:D006938 | Hyperlipoproteinemia Type II | atorvastatin | 7.88 | 16238680 | |
| MESH:D006938 | Hyperlipoproteinemia Type II | Simvastatin | 7.88 | 16238680 | |
| MESH:D006967 | Hypersensitivity | Butylated Hydroxytoluene | 3.68 | 17604070 | |
| MESH:D006973 | Hypertension | Arsenic | 11.24 | 16076760 9931084 11953799 | |
| MESH:D006973 | Hypertension | atorvastatin | 11.24 | 17042910 | |
| MESH:D006973 | Hypertension | Cyclosporine | 11.24 | 10903974 | |
| MESH:D006973 | Hypertension | Quercetin | 11.24 | 18356687 | |
| MESH:D006973 | Hypertension | Tetrachlorodibenzodioxin | 11.24 | 18850075 18670907 | |
| MESH:D006975 | Hypertension, Portal | Carbon Tetrachloride | 3.17 | 15338365 | |
| MESH:D006976 | Hypertension, Pulmonary | Copper Sulfate | 4.35 | 7265320 | |
| MESH:D006980 | Hyperthyroidism | marker/mechanism | 14678291 | ||
| MESH:D006980 | Hyperthyroidism | Methimazole | 4.71 | 14678291 | |
| MESH:D015228 | Hypertriglyceridemia | Triglycerides | 4.99 | 16238453 16979400 | |
| MESH:D017379 | Hypertrophy, Left Ventricular | resveratrol | 3.46 | 17488730 | |
| MESH:D006987 | Hypesthesia | Arsenic | 4.60 | 16093927 | |
| MESH:D007006 | Hypogonadism | Iron | 3.67 | 16640825 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 2.89 | 16945680 16569931 | |
| MESH:D007022 | Hypotension | Organophosphorus Compounds | 4.85 | 17098105 | |
| MESH:D007037 | Hypothyroidism | Iron | 14.33 | 16640825 | |
| MESH:D007037 | Hypothyroidism | Methimazole | 14.33 | 18031379 | |
| MESH:D007037 | Hypothyroidism | Propylthiouracil | 14.33 | 8137927 18031379 | |
| MESH:D020244 | Infarction, Middle Cerebral Artery | resveratrol | 3.73 | 17600658 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 2.59 | 12013081 | |
| MESH:D007248 | Infertility, Male | Diazinon | 13.80 | 16466525 12948887 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 13.80 | 17937319 | |
| MESH:D007248 | Infertility, Male | Lead | 13.80 | 16780224 | |
| MESH:D007248 | Infertility, Male | Parathion | 13.80 | 16029889 | |
| MESH:D007248 | Infertility, Male | sodium arsenite | 13.80 | 12646999 15346721 | |
| MESH:D007249 | Inflammation | Arachidonic Acid | 15.18 | 9831321 17371808 15177302 | |
| MESH:D007249 | Inflammation | atorvastatin | 15.18 | 16908763 | |
| MESH:D007249 | Inflammation | Diethylnitrosamine | 15.18 | 18785209 | |
| MESH:D007249 | Inflammation | perfluorooctanoic acid | 15.18 | 12083418 | |
| MESH:D007249 | Inflammation | Plant Oils | 15.18 | 10432208 | |
| MESH:D007249 | Inflammation | resveratrol | 15.18 | 16366677 | |
| MESH:D007249 | Inflammation | Tetrachlorodibenzodioxin | 15.18 | 12200463 12878042 | |
| MESH:D007251 | Influenza, Human | Quercetin | 13.18 | 16624496 | |
| MESH:D007251 | Influenza, Human | resveratrol | 13.18 | 16624496 | |
| MESH:D007251 | Influenza, Human | Vitamin E | 13.18 | 16624496 | |
| MESH:D007333 | Insulin Resistance | Estradiol | 12.04 | 16627594 16393666 | |
| MESH:D007333 | Insulin Resistance | orlistat | 12.04 | 17201808 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 12.04 | 16306350 | |
| MESH:D007333 | Insulin Resistance | Sodium Selenite | 12.04 | 14714311 | |
| MESH:D002532 | Intracranial Aneurysm | Reactive Oxygen Species | 4.16 | 19381132 | |
| MESH:D019189 | Iron Metabolism Disorders | Iron | 4.15 | 17163184 | |
| MESH:D007569 | Jaw Abnormalities | Tetrachlorodibenzodioxin | 2.48 | 16580747 | |
| MESH:D007627 | Keloid | Quercetin | 4.03 | 17086741 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 3.48 | 15604871 | |
| MESH:D007642 | Keratosis | Arsenic | 4.05 | 12749816 16930632 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 19.15 | 15629191 12587719 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 19.15 | 18776723 10903974 8314463 | |
| MESH:D007674 | Kidney Diseases | Estradiol | 19.15 | 15618244 | |
| MESH:D007674 | Kidney Diseases | Quercetin | 19.15 | 16962696 | |
| MESH:D007674 | Kidney Diseases | sodium arsenite | 19.15 | 20008137 | |
| MESH:D007674 | Kidney Diseases | tempol | 19.15 | 17640563 | |
| MESH:D007674 | Kidney Diseases | Vitamin E | 19.15 | 12488133 | |
| MESH:C531755 | Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules | orlistat | 5.68 | 17185156 | |
| MESH:D007676 | Kidney Failure, Chronic | Copper | 7.55 | 16518626 | |
| MESH:D007676 | Kidney Failure, Chronic | Hydrogen Peroxide | 7.55 | 16518626 | |
| MESH:D007680 | Kidney Neoplasms | 2,4-dinitrotoluene | 7.79 | 16705839 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 7.79 | 12371664 | |
| MESH:D007680 | Kidney Neoplasms | Estradiol | 7.79 | 15610895 | |
| MESH:D007683 | Kidney Tubular Necrosis, Acute | Calcium | 4.09 | 16316344 | |
| MESH:D007805 | Language Development Disorders | Methotrexate | 4.22 | 9562676 | |
| MESH:D007855 | Lead Poisoning | Lead | 4.99 | 16700817 | |
| MESH:D007859 | Learning Disorders | Cholesterol | 11.24 | 17134702 | |
| MESH:D007859 | Learning Disorders | Copper | 11.24 | 17134702 | |
| MESH:D007859 | Learning Disorders | Lead | 11.24 | 16384672 | |
| MESH:D007938 | Leukemia | Quercetin | 2.61 | 17468513 | |
| MESH:D015459 | Leukemia-Lymphoma, Adult T-Cell | Docosahexaenoic Acids | 4.15 | 17077332 | |
| MESH:D007948 | Leukemia, Monocytic, Acute | anthra(1,9-cd)pyrazol-6(2H)-one | 4.43 | 16972261 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | Arsenic | 5.61 | 17339181 | |
| MESH:D015473 | Leukemia, Promyelocytic, Acute | resveratrol | 5.61 | 16087638 | |
| MESH:D007970 | Leukopenia | Ciprofloxacin | 4.86 | 17846019 | |
| MESH:D020961 | Lewy Body Disease | Iron | 4.50 | 16563566 | |
| MESH:D007984 | Leydig Cell Tumor | perfluorooctanoic acid | 4.29 | 8812269 | |
| MESH:D008103 | Liver Cirrhosis | Carbon Tetrachloride | 17.92 | 16943688 16239168 17174718 17157831 17334410 11903743 21278145 16221502 11408273 | |
| MESH:D008103 | Liver Cirrhosis | Diethylnitrosamine | 17.92 | 19638242 20032147 18665156 18522880 18407596 | |
| MESH:D008103 | Liver Cirrhosis | Iron | 17.92 | 16640825 | |
| MESH:D008103 | Liver Cirrhosis | Methotrexate | 17.92 | 14986274 | |
| MESH:D008103 | Liver Cirrhosis | orlistat | 17.92 | 17404856 | |
| MESH:D008103 | Liver Cirrhosis | Phenobarbital | 17.92 | 21047994 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | atorvastatin | 13.34 | 17347453 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Carbon Tetrachloride | 13.34 | 12632514 18251166 18279442 17823541 12546737 17708605 16192424 17714472 12632512 18376398 17631135 14512876 16097048 17698563 10355542 18263696 17900296 17481882 12667390 16116963 17640975 12389079 20821823 18472094 15876570 18317297 18210741 18277467 15996030 16136751 12958196 18412020 15893842 17565644 15730626 16638106 15673190 18054572 15650968 12445418 17721639 18472332 16248980 17922224 11481614 15925388 12586293 16011737 18420326 15959796 12741479 14620537 16027843 17976157 18205269 15931870 18166357 15052691 18481824 15338365 12609069 12666154 18395095 18006644 12445421 17805973 13678700 15818738 17557913 16015684 12898905 14748882 18339082 15370692 18187930 12649538 15362042 17869086 15123356 17761835 18395914 14716496 17766677 17944888 17525996 18429990 18418968 16033810 15057751 18705752 14716833 14724832 18156304 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Estradiol | 13.34 | 14716833 14659978 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Fenofibrate | 13.34 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | naringenin | 13.34 | 14709902 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 13.34 | 15474484 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Plant Preparations | 13.34 | 17724770 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Quercetin | 13.34 | 12741479 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Tetrachlorodibenzodioxin | 13.34 | 12878042 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | Vitamin E | 13.34 | 16169303 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 19.23 | 16610002 11587558 12969438 16611625 19784758 12587719 19460945 19014921 | |
| MESH:D008107 | Liver Diseases | Arsenic | 19.23 | 11134558 | |
| MESH:D008107 | Liver Diseases | Carbon Tetrachloride | 19.23 | 16964402 17285989 15830285 15720792 16246199 | |
| MESH:D008107 | Liver Diseases | Chlorpyrifos | 19.23 | 15991261 | |
| MESH:D008107 | Liver Diseases | Diethylnitrosamine | 19.23 | 17034775 | |
| MESH:D008107 | Liver Diseases | Docosahexaenoic Acids | 19.23 | 17056761 | |
| MESH:D008107 | Liver Diseases | naringenin | 19.23 | 16945181 | |
| MESH:D008107 | Liver Diseases | Phenobarbital | 19.23 | 19363144 | |
| MESH:D008107 | Liver Diseases | Phenytoin | 19.23 | 14986274 | |
| MESH:D008108 | Liver Diseases, Alcoholic | Iron | 4.09 | 17207112 16737972 | |
| MESH:D017093 | Liver Failure | Carbon Tetrachloride | 3.24 | 15123358 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 6.62 | 16871587 17185352 | |
| MESH:D017114 | Liver Failure, Acute | Carbon Tetrachloride | 6.62 | 14706259 16899240 | |
| MESH:D008113 | Liver Neoplasms | Aflatoxin B1 | 48.57 | 15890375 9163691 18177683 2125692 | |
| MESH:D008113 | Liver Neoplasms | Arsenic | 48.57 | 16368122 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 48.57 | 20195826 21137059 | |
| MESH:D008113 | Liver Neoplasms | Butylated Hydroxytoluene | 48.57 | 18177683 | |
| MESH:D008113 | Liver Neoplasms | Carbon Tetrachloride | 48.57 | 19294768 | |
| MESH:D008113 | Liver Neoplasms | Clofibric Acid | 48.57 | 17602206 | |
| MESH:D008113 | Liver Neoplasms | Copper | 48.57 | 20302851 | |
| MESH:D008113 | Liver Neoplasms | Diethylnitrosamine | 48.57 | 16942905 20101389 2422723 19499222 20583210 18648771 19551842 20405173 19090486 18977376 19996281 15175105 19255062 19294768 20501860 19254457 18978307 19426721 15885732 20452335 9163691 20492335 19256749 19638242 21047994 18754104 19833225 18644402 19642983 12112319 21167192 19690152 21071580 12771043 19427195 10737359 19850985 20137499 20118626 21278145 2862719 19812893 20434301 19073162 | |
| MESH:D008113 | Liver Neoplasms | Fenofibrate | 48.57 | 18978307 | |
| MESH:D008113 | Liver Neoplasms | Iron | 48.57 | 20302851 16640825 | |
| MESH:D008113 | Liver Neoplasms | perfluorooctanoic acid | 48.57 | 18709148 14757943 | |
| MESH:D008113 | Liver Neoplasms | Phenobarbital | 48.57 | 19073162 19482888 15975961 19812893 21047994 8742319 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 48.57 | 20007298 15890375 16377806 | |
| MESH:D008113 | Liver Neoplasms | Quercetin | 48.57 | 18980244 | |
| MESH:D008113 | Liver Neoplasms | resveratrol | 48.57 | 19073162 19812893 20405173 19321006 | |
| MESH:D008113 | Liver Neoplasms | sodium arsenite | 48.57 | 15276417 16712894 | |
| MESH:D008113 | Liver Neoplasms | Tetrachlorodibenzodioxin | 48.57 | 16984957 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Aflatoxin B1 | 25.21 | 8603461 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Ascorbic Acid | 25.21 | 18544905 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Carbon Tetrachloride | 25.21 | 12014681 15583823 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Diethylnitrosamine | 25.21 | 19009564 17942915 2563599 18775883 19004024 18253720 18282651 18079962 21159647 18544905 17174075 18164116 19126423 3124819 19519916 16267830 17854601 18308698 19539802 18093689 16842330 9362446 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Fenofibrate | 25.21 | 18775883 18253720 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Methylcholanthrene | 25.21 | 598648 1399818 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Phenobarbital | 25.21 | 18308698 17172636 6150874 1399818 2563599 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Quercetin | 25.21 | 19519916 | |
| MESH:D008114 | Liver Neoplasms, Experimental | Tetrachlorodibenzodioxin | 25.21 | 12151625 | |
| MESH:D008171 | Lung Diseases | Ascorbic Acid | 11.86 | 16863852 | |
| MESH:D008171 | Lung Diseases | Ozone | 11.86 | 8266340 19066396 | |
| MESH:D008171 | Lung Diseases | sodium arsenite | 11.86 | 19095001 | |
| MESH:D008171 | Lung Diseases | Vitamin E | 11.86 | 16863852 | |
| MESH:D017563 | Lung Diseases, Interstitial | Methotrexate | 4.07 | 18516814 | |
| MESH:D055370 | Lung Injury | Ciprofloxacin | 14.31 | 18197910 | |
| MESH:D055370 | Lung Injury | Oleic Acid | 14.31 | 15090967 | |
| MESH:D055370 | Lung Injury | Oxygen | 14.31 | 18339021 | |
| MESH:D055370 | Lung Injury | Ozone | 14.31 | 20417186 | |
| MESH:D008175 | Lung Neoplasms | marker/mechanism | 16323636 | ||
| MESH:D008175 | Lung Neoplasms | Aflatoxin B1 | 26.97 | 14755239 | |
| MESH:D008175 | Lung Neoplasms | Arsenic | 26.97 | 17976673 19168569 17306315 | |
| MESH:D008175 | Lung Neoplasms | Ascorbic Acid | 26.97 | 16401635 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 26.97 | 18520028 6695378 20869020 20135361 17053015 20464547 20064080 18569708 18816296 | |
| MESH:D008175 | Lung Neoplasms | bexarotene | 26.97 | 17849452 | |
| MESH:D008175 | Lung Neoplasms | Butylated Hydroxytoluene | 26.97 | 11696405 18597497 19359593 11246140 15390079 19925653 16337739 | |
| MESH:D008175 | Lung Neoplasms | Ciprofloxacin | 26.97 | 20211752 | |
| MESH:D008175 | Lung Neoplasms | Diethylnitrosamine | 26.97 | 20970405 21163286 20512841 6695378 | |
| MESH:D008175 | Lung Neoplasms | Iron | 26.97 | 16640825 | |
| MESH:D008175 | Lung Neoplasms | Methylcholanthrene | 26.97 | 17909032 21163286 1399818 20970405 16337739 6695378 16271038 11893704 7750092 9230183 10545420 15390079 20512841 | |
| MESH:D008175 | Lung Neoplasms | Ozone | 26.97 | 8597069 7614698 | |
| MESH:D008175 | Lung Neoplasms | Polycyclic Hydrocarbons, Aromatic | 26.97 | 10814675 | |
| MESH:D008175 | Lung Neoplasms | Quercetin | 26.97 | 16280456 | |
| MESH:D008175 | Lung Neoplasms | sodium arsenite | 26.97 | 17306315 19931552 17077188 15276417 16712894 | |
| MESH:D008175 | Lung Neoplasms | Tetrachlorodibenzodioxin | 26.97 | 19555203 11884234 | |
| MESH:D008175 | Lung Neoplasms | Vitamin E | 26.97 | 11062179 | |
| MESH:D008207 | Lymphatic Metastasis | orlistat | 4.98 | 18770866 20805790 | |
| MESH:D008223 | Lymphoma | Methotrexate | 3.24 | 17352296 | |
| MESH:D016393 | Lymphoma, B-Cell | resveratrol | 7.36 | 17088997 | |
| MESH:D016393 | Lymphoma, B-Cell | Sodium Selenite | 7.36 | 14737004 | |
| MESH:D008228 | Lymphoma, Non-Hodgkin | resveratrol | 3.08 | 14749477 | |
| MESH:D016410 | Lymphoma, T-Cell, Cutaneous | bexarotene | 4.22 | 11161223 | |
| MESH:D008268 | Macular Degeneration | Iron | 3.37 | 16640825 | |
| MESH:D015674 | Mammary Neoplasms, Animal | resveratrol | 3.32 | 15688416 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | bexarotene | 8.82 | 19196722 15591091 19196723 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Butylated Hydroxytoluene | 8.82 | 1500032 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | Estradiol | 8.82 | 17203775 11807958 16891317 11408345 | |
| MESH:D008325 | Mammary Neoplasms, Experimental | resveratrol | 8.82 | 8985016 11606380 | |
| MESH:D020149 | Manganese Poisoning | Estradiol | 3.53 | 19453300 | |
| MESH:D008545 | Melanoma | orlistat | 5.13 | 20805790 18770866 | |
| MESH:D008545 | Melanoma | Reactive Oxygen Species | 5.13 | 17992120 | |
| MESH:D008545 | Melanoma | resveratrol | 5.13 | 17992120 | |
| MESH:D008545 | Melanoma | sodium arsenite | 5.13 | 19082730 16487513 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 2.65 | 19513568 | |
| MESH:D008569 | Memory Disorders | Lead | 4.28 | 16384672 17263510 | |
| MESH:D007706 | Menkes Kinky Hair Syndrome | Copper | 4.94 | 17109627 17268249 | |
| MESH:D008607 | Mental Retardation | Phenytoin | 3.25 | 9212184 | |
| MESH:D008659 | Metabolic Diseases | resveratrol | 3.52 | 17112576 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 3.83 | 16801185 | |
| MESH:D008679 | Metaplasia | Ozone | 4.15 | 10496685 | |
| OMIM:612633 | MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5 | marker/mechanism | |||
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 6.39 | 16381670 | |
| MESH:D009062 | Mouth Neoplasms | Plant Preparations | 6.39 | 17418620 | |
| MESH:D052016 | Mucositis | Methotrexate | 4.34 | 17488658 | |
| MESH:D009101 | Multiple Myeloma | fluvastatin | 5.53 | 16996129 | |
| MESH:D009101 | Multiple Myeloma | resveratrol | 5.53 | 17935668 17049120 16267019 16490592 14749477 17164350 | |
| MESH:D020528 | Multiple Sclerosis, Chronic Progressive | Iron | 4.71 | 17086897 | |
| MESH:D009134 | Muscular Atrophy, Spinal | resveratrol | 3.93 | 17962980 | |
| MESH:D009135 | Muscular Diseases | atorvastatin | 12.64 | 16239165 | |
| MESH:D009135 | Muscular Diseases | orlistat | 12.64 | 18430571 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 12.64 | 16239165 | |
| MESH:D009164 | Mycobacterium Infections | Ciprofloxacin | 8.47 | 10063276 | |
| MESH:D009164 | Mycobacterium Infections | orlistat | 8.47 | 21442799 | |
| MESH:D009181 | Mycoses | Iron | 4.51 | 16640825 | |
| MESH:D009190 | Myelodysplastic Syndromes | Ciprofloxacin | 4.01 | 9809623 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 6.52 | 19151258 | |
| MESH:D009203 | Myocardial Infarction | Quercetin | 6.52 | 19595682 | |
| MESH:D009203 | Myocardial Infarction | resveratrol | 6.52 | 16317513 17125593 16456233 16525036 17015251 17188708 | |
| MESH:D017202 | Myocardial Ischemia | Arsenic | 15.44 | 15371236 | |
| MESH:D017202 | Myocardial Ischemia | Iron | 15.44 | 16604332 | |
| MESH:D017202 | Myocardial Ischemia | resveratrol | 15.44 | 17015251 17125593 | |
| MESH:D017202 | Myocardial Ischemia | Tetrachlorodibenzodioxin | 15.44 | 12213967 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Estradiol | 14.04 | 16810080 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Iron | 14.04 | 16604332 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 14.04 | 16411023 | |
| MESH:D015428 | Myocardial Reperfusion Injury | Quercetin | 14.04 | 19207477 | |
| MESH:D009205 | Myocarditis | resveratrol | 3.82 | 17322642 | |
| MESH:D020191 | Myoclonic Epilepsies, Progressive | Phenobarbital | 9.37 | 17484760 | |
| MESH:D020191 | Myoclonic Epilepsies, Progressive | Phenytoin | 9.37 | 17484760 | |
| MESH:D009224 | Myotonia Congenita | Phenytoin | 4.47 | 1896199 | |
| MESH:D009336 | Necrosis | 2,4-dinitrotoluene | 2.93 | 18551238 | |
| MESH:D016870 | Neisseriaceae Infections | Ciprofloxacin | 5.41 | 20378725 | |
| MESH:D009362 | Neoplasm Metastasis | Diethylnitrosamine | 2.10 | 9029167 3581430 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 12.38 | 11141357 | |
| MESH:D009369 | Neoplasms | naringenin | 12.38 | 15185748 | |
| MESH:D009369 | Neoplasms | orlistat | 12.38 | 18710210 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 12.38 | 17405874 | |
| MESH:D009369 | Neoplasms | Quercetin | 12.38 | 15185748 | |
| MESH:D009369 | Neoplasms | sodium arsenite | 12.38 | 11559025 | |
| MESH:D009374 | Neoplasms, Experimental | orlistat | 10.22 | 19381703 | |
| MESH:D009374 | Neoplasms, Experimental | resveratrol | 10.22 | 8985016 | |
| MESH:D009374 | Neoplasms, Experimental | sodium arsenite | 10.22 | 20056578 | |
| MESH:D009376 | Neoplasms, Hormone-Dependent | bexarotene | 3.83 | 19196722 | |
| MESH:D009389 | Neovascularization, Pathologic | Copper | 11.85 | 17308104 | |
| MESH:D009389 | Neovascularization, Pathologic | Estradiol | 11.85 | 17289903 | |
| MESH:D009389 | Neovascularization, Pathologic | orlistat | 11.85 | 17012255 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 3.48 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | atorvastatin | 11.22 | 19348381 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 11.22 | 19348381 18481113 | |
| MESH:D009404 | Nephrotic Syndrome | Iron | 11.22 | 17178036 | |
| MESH:D009421 | Nervous System Malformations | Estradiol | 6.49 | 16427766 11399458 | |
| MESH:D009421 | Nervous System Malformations | Tetrachlorodibenzodioxin | 6.49 | 14600291 | |
| MESH:D009436 | Neural Tube Defects | Arsenic | 8.34 | 16620997 | |
| MESH:D009436 | Neural Tube Defects | Phenytoin | 8.34 | 9118846 | |
| MESH:D009436 | Neural Tube Defects | sodium arsenite | 8.34 | 12854658 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 13.58 | 18514411 | |
| MESH:D019636 | Neurodegenerative Diseases | Diethylnitrosamine | 13.58 | 20387270 | |
| MESH:D019636 | Neurodegenerative Diseases | Iron | 13.58 | 17296847 16604332 | |
| MESH:D019636 | Neurodegenerative Diseases | resveratrol | 13.58 | 17652729 | |
| MESH:D018242 | Neuroectodermal Tumors, Primitive | marker/mechanism | 16002382 | ||
| MESH:D020078 | Neurogenic Inflammation | Arsenic | 12.75 | 17056641 | |
| MESH:D020078 | Neurogenic Inflammation | Quercetin | 12.75 | 17929310 | |
| MESH:D020078 | Neurogenic Inflammation | resveratrol | 12.75 | 17929310 | |
| MESH:D009461 | Neurologic Manifestations | Diethylnitrosamine | 4.16 | 20387270 | |
| MESH:D020258 | Neurotoxicity Syndromes | Chlorpyrifos | 6.75 | 15081274 | |
| MESH:D020258 | Neurotoxicity Syndromes | Insecticides | 6.75 | 19861644 | |
| MESH:D009503 | Neutropenia | Ciprofloxacin | 4.29 | 17846019 | |
| MESH:D052556 | Niemann-Pick Disease, Type C | Cholesterol | 9.28 | 20557099 9802331 | |
| MESH:D052556 | Niemann-Pick Disease, Type C | perfluorooctanoic acid | 9.28 | 9802331 | |
| MESH:C541083 | Non-alcoholic Fatty Liver Disease | orlistat | 4.70 | 17404856 | |
| MESH:D009765 | Obesity | Ascorbic Acid | 5.56 | 17217161 | |
| MESH:D009765 | Obesity | orlistat | 5.56 | 20518802 18773755 21442799 20065556 21438711 19046740 19461584 20002075 20540997 19207292 20599501 16938137 | |
| MESH:D009765 | Obesity | pirinixic acid | 5.56 | 20558911 | |
| MESH:D009784 | Occupational Diseases | 2,4-dinitrotoluene | 2.60 | 16049721 12819281 | |
| MESH:D010003 | Osteoarthritis | Iron | 3.32 | 16640825 | |
| MESH:D010018 | Osteomalacia | Phenobarbital | 8.96 | 17016548 | |
| MESH:D010018 | Osteomalacia | Phenytoin | 8.96 | 17016548 | |
| MESH:D010024 | Osteoporosis | Calcium | 8.39 | 17882678 | |
| MESH:D010024 | Osteoporosis | Iron | 8.39 | 16648989 16640825 | |
| MESH:D010024 | Osteoporosis | Levonorgestrel | 8.39 | 12665316 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | Quercetin | 7.29 | 19495926 | |
| MESH:D015663 | Osteoporosis, Postmenopausal | resveratrol | 7.29 | 17513867 | |
| MESH:D010051 | Ovarian Neoplasms | Arsenic | 7.78 | 17306315 | |
| MESH:D010051 | Ovarian Neoplasms | Estradiol | 7.78 | 19401270 | |
| MESH:D010051 | Ovarian Neoplasms | Quercetin | 7.78 | 19005980 | |
| MESH:D010051 | Ovarian Neoplasms | sodium arsenite | 7.78 | 17306315 15276417 | |
| MESH:D010146 | Pain | Acetaminophen | 4.42 | 16870215 | |
| MESH:D010146 | Pain | Phenytoin | 4.42 | 15215642 | |
| MESH:D010190 | Pancreatic Neoplasms | Diethylnitrosamine | 8.53 | 16540662 | |
| MESH:D010190 | Pancreatic Neoplasms | Phenobarbital | 8.53 | 16965848 | |
| MESH:D010190 | Pancreatic Neoplasms | Quercetin | 8.53 | 16965848 | |
| MESH:D010190 | Pancreatic Neoplasms | Reactive Oxygen Species | 8.53 | 15580305 | |
| MESH:D010195 | Pancreatitis | Insecticides | 9.71 | 16258382 3421227 | |
| MESH:D010195 | Pancreatitis | orlistat | 9.71 | 20065556 16938137 | |
| MESH:D010195 | Pancreatitis | Taurocholic Acid | 9.71 | 20035747 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 2.80 | 11578682 | |
| MESH:D010212 | Papilloma | Hydrogen Peroxide | 6.66 | 12065085 | |
| MESH:D010212 | Papilloma | Iron | 6.66 | 12065085 | |
| MESH:D020447 | Parasomnias | Iron | 5.06 | 17352947 | |
| MESH:D010300 | Parkinson Disease | Iron | 2.90 | 16563566 16640825 | |
| MESH:D010382 | Peliosis Hepatis | Tetrachlorodibenzodioxin | 3.29 | 12520081 | |
| MESH:D010523 | Peripheral Nervous System Diseases | Arsenic | 3.29 | 16093927 | |
| MESH:D016491 | Peripheral Vascular Diseases | Arsenic | 4.05 | 16905509 15371236 6392382 | |
| MESH:D010538 | Peritonitis | Ozone | 3.22 | 16369182 | |
| MESH:D018923 | Persian Gulf Syndrome | marker/mechanism | 10373407 | ||
| MESH:D010787 | Photosensitivity Disorders | 4-hydroxy-2-nonenal | 4.54 | 11550810 | |
| MESH:D010900 | Pituitary Diseases | Iron | 4.71 | 16604332 | |
| MESH:D011014 | Pneumonia | Butylated Hydroxytoluene | 8.22 | 11893704 | |
| MESH:D011014 | Pneumonia | Ozone | 8.22 | 18381685 18007984 18929643 | |
| MESH:D011017 | Pneumonia, Lipid | Phosphoric Acid Esters | 6.75 | 12803600 | |
| MESH:D011041 | Poisoning | marker/mechanism | |||
| MESH:D011041 | Poisoning | Diazinon | 22.29 | 17603234 | |
| MESH:D011041 | Poisoning | Iron | 22.29 | 16604332 | |
| MESH:D011041 | Poisoning | Obidoxime Chloride | 22.29 | 8134223 | |
| MESH:D011041 | Poisoning | Organophosphorus Compounds | 22.29 | 17098105 | |
| MESH:D011041 | Poisoning | Sarin | 22.29 | 16914529 | |
| MESH:D011041 | Poisoning | Soman | 22.29 | 16914529 | |
| MESH:D011085 | Polycystic Ovary Syndrome | ethinyl estradiol-desogestrel combination | 12.32 | 17105841 | |
| MESH:D011085 | Polycystic Ovary Syndrome | orlistat | 12.32 | 17201808 | |
| MESH:D011085 | Polycystic Ovary Syndrome | Simvastatin | 12.32 | 17105841 | |
| MESH:D017689 | Polydactyly | Phenytoin | 4.22 | 9212184 | |
| MESH:D011115 | Polyneuropathies | Organophosphorus Compounds | 5.33 | 16042503 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Iron | 8.03 | 16640825 | |
| MESH:D017119 | Porphyria Cutanea Tarda | Tetrachlorodibenzodioxin | 8.03 | 18163543 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 15.19 | 12371664 | |
| MESH:D011230 | Precancerous Conditions | Diethylnitrosamine | 15.19 | 2563599 | |
| MESH:D011230 | Precancerous Conditions | Phenobarbital | 15.19 | 2563599 | |
| MESH:D011230 | Precancerous Conditions | Quercetin | 15.19 | 19056647 | |
| MESH:D011225 | Pre-Eclampsia | Iron | 3.65 | 16640825 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Lead | 20.73 | 16384672 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | perfluorooctanoic acid | 20.73 | 17132714 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Pesticides | 20.73 | 17938740 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | resveratrol | 20.73 | 16679765 | |
| MESH:D011297 | Prenatal Exposure Delayed Effects | Tetrachlorodibenzodioxin | 20.73 | 11222880 11399792 11896295 11118676 | |
| MESH:D019048 | Prostatic Intraepithelial Neoplasia | Estradiol | 3.02 | 20887781 | |
| MESH:D011471 | Prostatic Neoplasms | marker/mechanism | 12783936 15538743 | ||
| MESH:D011471 | Prostatic Neoplasms | Arsenic | 2.33 | 16140617 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 2.33 | 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | Copper | 2.33 | 17308104 17079463 | |
| MESH:D011471 | Prostatic Neoplasms | Estradiol | 2.33 | 16740699 | |
| MESH:D011471 | Prostatic Neoplasms | Quercetin | 2.33 | 14715546 17292933 | |
| MESH:D011471 | Prostatic Neoplasms | resveratrol | 2.33 | 15767336 17675339 16731767 17804756 17718901 17636462 | |
| MESH:D011471 | Prostatic Neoplasms | sodium arsenite | 2.33 | 16039940 | |
| MESH:D011471 | Prostatic Neoplasms | Sodium Selenite | 2.33 | 18760546 | |
| MESH:D011471 | Prostatic Neoplasms | Vitamin E | 2.33 | 15084515 | |
| MESH:D011507 | Proteinuria | Arsenic | 3.14 | 21343184 | |
| MESH:D011528 | Protozoan Infections | Iron | 5.06 | 16640825 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 6.91 | 15861022 16919318 | |
| MESH:D011537 | Pruritus | Levonorgestrel | 6.91 | 15861022 | |
| MESH:D019310 | Pseudolymphoma | Phenobarbital | 9.39 | 12752131 | |
| MESH:D019310 | Pseudolymphoma | Phenytoin | 9.39 | 8603615 12752131 1419762 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 4.39 | 16882103 | |
| MESH:D011565 | Psoriasis | Methotrexate | 4.39 | 17410198 | |
| MESH:D011654 | Pulmonary Edema | Oleic Acid | 4.85 | 15090967 | |
| MESH:D011657 | Pulmonary Eosinophilia | Ascorbic Acid | 4.38 | 14606601 | |
| MESH:D012003 | Rectal Fistula | Ciprofloxacin | 5.41 | 18371140 | |
| MESH:D012035 | Refsum Disease | orlistat | 5.13 | 20871815 | |
| MESH:D051437 | Renal Insufficiency | Methotrexate | 3.80 | 17352296 | |
| MESH:D051436 | Renal Insufficiency, Chronic | resveratrol | 4.62 | 16325855 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 4.66 | 19058328 | |
| MESH:D015427 | Reperfusion Injury | resveratrol | 4.66 | 17520802 16317513 16314181 17058453 15827377 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Oleic Acid | 7.08 | 18549715 | |
| MESH:D012128 | Respiratory Distress Syndrome, Adult | Oxygen | 7.08 | 17627322 18339021 | |
| MESH:D012131 | Respiratory Insufficiency | Organophosphorus Compounds | 5.38 | 17098105 16449848 | |
| MESH:D012135 | Respiratory Sounds | Chlorpyrifos | 11.34 | 16611668 17119214 11874814 | |
| MESH:D012135 | Respiratory Sounds | Parathion | 11.34 | 11874814 17119214 | |
| MESH:D012135 | Respiratory Sounds | Pesticides | 11.34 | 17119214 | |
| MESH:D015619 | Respiratory System Abnormalities | Tetrachlorodibenzodioxin | 2.93 | 18990726 | |
| MESH:D012140 | Respiratory Tract Diseases | Chlorpyrifos | 12.69 | 17119214 16611668 | |
| MESH:D012140 | Respiratory Tract Diseases | Parathion | 12.69 | 17119214 | |
| MESH:D012140 | Respiratory Tract Diseases | Pesticides | 12.69 | 17119214 | |
| MESH:D012148 | Restless Legs Syndrome | Iron | 3.79 | 16930377 | |
| MESH:D012174 | Retinitis Pigmentosa | Ascorbic Acid | 2.95 | 16849425 | |
| MESH:D012554 | Schistosomiasis japonica | Quercetin | 4.59 | 16862918 | |
| MESH:D012559 | Schizophrenia | Copper | 2.92 | 16842975 | |
| MESH:D012640 | Seizures | 2,4-dinitrotoluene | 8.52 | 18551238 | |
| MESH:D012640 | Seizures | Phenobarbital | 8.52 | 3137016 11442880 4039156 16876388 | |
| MESH:D012640 | Seizures | Phenytoin | 8.52 | 16876388 9844417 3691417 11044598 19919933 3137016 10029267 15946322 | |
| MESH:D012640 | Seizures | Soman | 8.52 | 10087439 | |
| MESH:D003294 | Seizures, Febrile | Phenobarbital | 3.88 | 6407741 | |
| MESH:D012729 | Sex Chromosome Aberrations | Chlorpyrifos | 5.13 | 6418539 | |
| MESH:D012852 | Sinusitis | Ampicillin | 5.58 | 7327846 | |
| MESH:D012871 | Skin Diseases | Arsenic | 5.87 | 18709164 17050553 16759981 17938729 6392382 17548696 16702368 19834688 17453740 15952646 16353154 | |
| MESH:D012871 | Skin Diseases | Ascorbic Acid | 5.87 | 18709164 | |
| MESH:D012871 | Skin Diseases | Vitamin E | 5.87 | 18709164 | |
| MESH:D012878 | Skin Neoplasms | Arsenic | 18.65 | 17976673 15504454 17029826 16251483 17050553 19538983 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 18.65 | 19755658 10029692 | |
| MESH:D012878 | Skin Neoplasms | Hydrogen Peroxide | 18.65 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | Iron | 18.65 | 12065085 | |
| MESH:D012878 | Skin Neoplasms | resveratrol | 18.65 | 15837718 8985016 | |
| MESH:D012878 | Skin Neoplasms | sodium arsenite | 18.65 | 19524636 18572023 | |
| MESH:D012878 | Skin Neoplasms | Tetrachlorodibenzodioxin | 18.65 | 16192470 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 2.99 | 16709447 | |
| MESH:D016135 | Spinal Dysraphism | sodium arsenite | 3.02 | 12854658 | |
| MESH:D013262 | Stevens-Johnson Syndrome | Phenytoin | 4.24 | 20235791 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 3.49 | 20155912 2093021 | |
| MESH:D013274 | Stomach Neoplasms | Diethylnitrosamine | 3.49 | 18456281 | |
| MESH:D013274 | Stomach Neoplasms | Docosahexaenoic Acids | 3.49 | 19015929 | |
| MESH:D013274 | Stomach Neoplasms | orlistat | 3.49 | 19381703 | |
| MESH:D013276 | Stomach Ulcer | Ascorbic Acid | 7.76 | 18726076 | |
| MESH:D013276 | Stomach Ulcer | olive oil | 7.76 | 12498302 16252198 | |
| MESH:D013276 | Stomach Ulcer | Plant Oils | 7.76 | 16252198 | |
| MESH:D020521 | Stroke | Ascorbic Acid | 6.28 | 16517955 16403987 | |
| MESH:D020521 | Stroke | Vitamin E | 6.28 | 16517955 | |
| OMIM:601367 | STROKE, ISCHEMIC | resveratrol | 3.63 | 16321402 | |
| MESH:D013398 | Sudden Infant Death | Iron | 10.20 | 16640825 | |
| MESH:D013398 | Sudden Infant Death | Oxygen | 10.20 | 12563064 | |
| MESH:D013576 | Syndactyly | Methotrexate | 4.13 | 9562676 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 8.19 | 11994571 | |
| MESH:D019851 | Thrombophilia | ethinyl estradiol-desogestrel combination | 8.19 | 11994571 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 2.34 | 15669648 | |
| MESH:D013959 | Thyroid Diseases | Tetrachlorodibenzodioxin | 2.95 | 12697716 | |
| MESH:D013964 | Thyroid Neoplasms | Diethylnitrosamine | 7.68 | 7505956 | |
| MESH:D013964 | Thyroid Neoplasms | Phenobarbital | 7.68 | 1399818 | |
| MESH:D013964 | Thyroid Neoplasms | Propylthiouracil | 7.68 | 15710170 | |
| MESH:D013978 | Tibial Fractures | Estradiol | 3.73 | 19048282 | |
| MESH:D014062 | Tongue Neoplasms | resveratrol | 3.37 | 16227395 | |
| MESH:D014123 | Toxoplasmosis | Ciprofloxacin | 5.06 | 20186551 | |
| MESH:D014202 | Tremor | Lead | 4.54 | 21145352 | |
| MESH:D014376 | Tuberculosis | Chenodeoxycholic Acid | 6.60 | 16040207 | |
| MESH:D014376 | Tuberculosis | Iron | 6.60 | 16597321 | |
| MESH:D001749 | Urinary Bladder Neoplasms | 2,4-dinitrotoluene | 16.53 | 16049721 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Arsenic | 16.53 | 19322015 17306315 11144890 19429237 17976673 18640142 15987713 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 16.53 | 17053015 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Ciprofloxacin | 16.53 | 15028437 10741713 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Plant Preparations | 16.53 | 11251952 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Quercetin | 16.53 | 16720314 | |
| MESH:D001749 | Urinary Bladder Neoplasms | sodium arsenite | 16.53 | 16452187 16712894 11723127 17306315 | |
| MESH:D014570 | Urologic Diseases | Diazinon | 4.32 | 16487989 | |
| MESH:D014571 | Urologic Neoplasms | 2,4-dinitrotoluene | 3.37 | 10091137 | |
| MESH:D014581 | Urticaria | Acetaminophen | 2.12 | 10982225 | |
| MESH:D002583 | Uterine Cervical Neoplasms | resveratrol | 6.78 | 17473185 | |
| MESH:D002583 | Uterine Cervical Neoplasms | sodium arsenite | 6.78 | 11813266 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 6.53 | 14692618 | |
| MESH:D014594 | Uterine Neoplasms | resveratrol | 6.53 | 17044934 | |
| MESH:D014605 | Uveitis | Cyclosporine | 3.03 | 1336536 | |
| MESH:D014652 | Vascular Diseases | Arsenic | 8.73 | 17056641 | |
| MESH:D014652 | Vascular Diseases | sodium arsenite | 8.73 | 17056641 | |
| MESH:D054079 | Vascular Malformations | Tetrachlorodibenzodioxin | 3.63 | 12125929 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 12.97 | 14671159 15869587 | |
| MESH:D020246 | Venous Thrombosis | ethinyl estradiol-desogestrel combination | 12.97 | 15869587 | |
| MESH:D020246 | Venous Thrombosis | Levonorgestrel | 12.97 | 15869587 | |
| MESH:D018487 | Ventricular Dysfunction, Left | resveratrol | 3.39 | 17488730 | |
| MESH:D019282 | Wasting Syndrome | Tetrachlorodibenzodioxin | 3.29 | 15886252 | |
| MESH:D014947 | Wounds and Injuries | Plant Oils | 4.76 | 16313111 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 3.48 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:01100 | Metabolic pathways |
| No data |
| Releated disease ID | Related disease Name |
|---|---|
| PA443359 | Aneurysm |
| PA446509 | Aortic Aneurysm, Abdominal |
| PA443434 | Arthritis, Rheumatoid |
| PA443434 | Arthritis, Rheumatoid |
| PA443796 | Coronary Artery Disease |
| PA447054 | Stroke |
| PA444814 | Lung Diseases |
| Releated drug ID | Related drug Name |
|---|---|
| PA133950441 | hmg coa reductase inhibitors |
| PA449053 | clopidogrel |
| PA10004 | adalimumab |
| PA449515 | etanercept |
| PA452639 | infliximab |
| PA448073 | ethanol |
| PA128406983 | pesticides |
| PA451257 | risperidone |
| PA448500 | atorvastatin |
| Drugbank ID | Action | Drug Name | Description |
|---|---|---|---|
| DB01327 | antagonist | Cefazolin | Anti-Bacterial Agents;Cephalosporins |
| No data |
| No data |
| No data |