AutismKB 2.0

Annotation Detail for KCTD5


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Basic Information Top
Gene Symbol:KCTD5 ( FLJ20040 )
Gene Full Name: potassium channel tetramerisation domain containing 5
Band: 16p13.3
Quick LinksEntrez ID:54442; OMIM: 611285; Uniprot ID:KCTD5_HUMAN; ENSEMBL ID: ENSG00000167977; HGNC ID: 21423
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KCTD5 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KCTD5 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of KCTD5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KCTD5 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of KCTD5 mRNAdecreases expression 17326132
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KCTD5 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of KCTD5 mRNAincreases expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of KCTD5 mRNAdecreases expression 20713471
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.287525203
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.333712494
MESH:D000236 Adenoma Methylcholanthrene 7.336695378 10545420
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5811922910
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Homocysteine 2.2420468076 16297937
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8517474063
MESH:D002277 Carcinoma Methylcholanthrene 4.1610545420
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6816705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.683581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.8514694615
MESH:D002386 Cataract Acetaminophen 7.8510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.397505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.3920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.3912371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 17.3916192471
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.4719486331
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.3715095906
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.108970840 8156756 11298694 12868966 11906362 18759878 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.5118692083 6482804 18289764 6679447 9022650 16192314 7440962 9653073 9328219 11289319 1440618 8291058 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.5121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5112153990 15968718 11739529 17906064 10663392 16227642 11529661 19739265 12594235 19416960 15619225 11287661 19164858 10915739 16485898 10774834 12540782 16177239 19370779 12705907 14550746 17522070 17562736 11421492 2444490 14725611 18713872 12958197 19923254 14986274 16393943 11461765 11743745 16081117 12392966 16109766 19420014 16781746 19085960 18071297 11834606
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.563581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5620426865
MESH:D017889 Exfoliation Syndrome Homocysteine 6.0416504073
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.2814633661 10962813
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005901 Glaucoma Homocysteine 5.5516504073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006330 Heart Defects, Congenital Homocysteine 4.1219638421
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.9217292331 18234410 17369066
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.576582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.339327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6712587719 19014921 11587558 19460945 16611625 12969438 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.631399818 598648 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.631399818 598648
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.416695378 1399818 17909032 7750092 11893704 15390079 20512841 16337739 21163286 16271038 10545420 9230183 20970405
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Homocysteine 5.8416602021
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009203 Myocardial Infarction Homocysteine 3.8017412321
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.5216049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.526482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.5214694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010300 Parkinson Disease Homocysteine 3.6416275827
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066582329 7505956 3712494 1399818 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6510091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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