Gene Symbol:	XRN1 ( DKFZp434P0721,DKFZp686B22225,DKFZp686F19113,FLJ41903,SEP1 )
Gene Full Name:	5'-3' exoribonuclease 1
Band:	3q23
Quick Links	Entrez ID:54464; OMIM: 607994; Uniprot ID:XRN1_HUMAN; ENSEMBL ID: ENSG00000114127; HGNC ID: 30654
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C035207	4-amino-2,6-dinitrotoluene	4-amino-2,6-dinitrotoluene affects the expression of XRN1 mRNA	affects expression	21346803
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of XRN1 mRNA	increases expression	18687144
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of XRN1 mRNA	decreases expression	20064835
D003907	Dexamethasone	Dexamethasone results in increased expression of XRN1 mRNA	increases expression	17998272

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	4-amino-2,6-dinitrotoluene	4.58	7525203
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	2.06	20464547 20127859
MESH:D000236	Adenoma	Benzo(a)pyrene	2.86	6695378
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	4.64	19183758
MESH:D001169	Arthritis, Experimental	Dexamethasone	3.76	17659584
MESH:D001943	Breast Neoplasms	Benzo(a)pyrene	1.99	17474063 20146248
MESH:D002294	Carcinoma, Squamous Cell	Benzo(a)pyrene	2.13	20419170
MESH:D002386	Cataract	4-amino-2,6-dinitrotoluene	3.84	14694615
MESH:D003110	Colonic Neoplasms	Dexamethasone	2.54	15824018
MESH:D000013	Congenital Abnormalities	4-amino-2,6-dinitrotoluene	4.53	15095906
MESH:D019465	Craniofacial Abnormalities	Dexamethasone	2.29	17728286
MESH:D017449	Dermatitis, Allergic Contact	Dexamethasone	3.96	12438553
MESH:D003967	Diarrhea	Dexamethasone	4.20	7237001
MESH:D056486	Drug-Induced Liver Injury	4-amino-2,6-dinitrotoluene	2.72	21346803
MESH:D004485	Eczema	Dexamethasone	4.97	12438553
MESH:D004487	Edema	Dexamethasone	3.82	19703484
MESH:D004938	Esophageal Neoplasms	Benzo(a)pyrene	2.08	16530937
MESH:D006330	Heart Defects, Congenital	Benzo(a)pyrene	2.83	20471113
MESH:D006548	Hernia, Diaphragmatic	Dexamethasone	3.18	7520565
MESH:D006973	Hypertension	Dexamethasone	3.05	17042910
MESH:D007249	Inflammation	Dexamethasone	3.05	8960868 11099482
MESH:D008106	Liver Cirrhosis, Experimental	Dexamethasone	2.27	16718785
MESH:D008113	Liver Neoplasms	Benzo(a)pyrene	2.15	21137059 20195826
MESH:D055370	Lung Injury	Asbestos, Crocidolite	4.58	17365036
MESH:D008175	Lung Neoplasms	Benzo(a)pyrene	2.65	18569708 20135361 18816296 20064080 18520028 20869020 17053015 6695378 20464547
MESH:D008175	Lung Neoplasms	Dexamethasone	2.65	11195469 15824018
MESH:D008654	Mesothelioma	Asbestos, Crocidolite	3.31	16966607 16166281 18303189
MESH:D009062	Mouth Neoplasms	Benzo(a)pyrene	3.50	16381670
MESH:D009101	Multiple Myeloma	Dexamethasone	3.78	15867202 16118317 15744524
MESH:D009190	Myelodysplastic Syndromes	Dexamethasone	3.74	9809623
MESH:D009369	Neoplasms	Benzo(a)pyrene	2.33	11141357
MESH:D009784	Occupational Diseases	4-amino-2,6-dinitrotoluene	4.49	14694615
MESH:D010995	Pleural Diseases	Asbestos, Crocidolite	5.45	10923243
MESH:D054198	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Dexamethasone	3.74	21297632
MESH:D011471	Prostatic Neoplasms	Benzo(a)pyrene	2.91	17292933
MESH:D011658	Pulmonary Fibrosis	Asbestos, Crocidolite	3.15	17322281 17975199 15814490 17365031
MESH:D012128	Respiratory Distress Syndrome, Adult	Dexamethasone	4.48	11700416 18379247
MESH:D012878	Skin Neoplasms	Benzo(a)pyrene	2.52	10029692 19755658
MESH:D013272	Stomach Diseases	Dexamethasone	4.95	15472012
MESH:D013274	Stomach Neoplasms	Benzo(a)pyrene	1.56	20155912 2093021
MESH:D013276	Stomach Ulcer	Dexamethasone	3.91	15138204
MESH:D001749	Urinary Bladder Neoplasms	Benzo(a)pyrene	2.30	17053015
MESH:D014605	Uveitis	Dexamethasone	5.54	1336536

Pathway ID	Pathway Name
REACT:21257	Metabolism of RNA
KEGG:03008	Ribosome biogenesis in eukaryotes
KEGG:03018	RNA degradation

AutismKB 2.0

Annotation Detail for XRN1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics