AutismKB 2.0

Annotation Detail for RNF216


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Basic Information Top
Gene Symbol:RNF216 ( TRIAD3,U7I1,UBCE7IP1,ZIN )
Gene Full Name: ring finger protein 216
Band: 7p22.1
Quick LinksEntrez ID:54476; OMIM: 609948; Uniprot ID:RN216_HUMAN; ENSEMBL ID: ENSG00000011275; HGNC ID: 21698
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic affects the expression of RNF216 mRNAaffects expression 18414638
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RNF216 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RNF216 mRNAincreases expression 19465110
C025643 vinclozolin vinclozolin results in increased expression of RNF216 mRNAincreases expression 18940246
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4715322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.1016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.1016835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.9417306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001008 Anxiety Disorders vinclozolin 3.9719015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9512569548 16835338 18414634 16251483
MESH:D050197 Atherosclerosis Arsenic 3.4612928151 19371607
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.2219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7817687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.3216507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7715504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.4718640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.7115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.6818022660 16973168
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2412621046 15668235 8697196 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 15322242 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.8514966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema pirinixic acid 7.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.9712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver pirinixic acid 3.1919236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005534 Foot Diseases Arsenic 6.286392382
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.5716973722
MESH:D005832 Genital Diseases, Male vinclozolin 6.0216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly pirinixic acid 10.1919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.1912621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 18606429 16354765 15340226 8697196
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.8517050553
MESH:D006973 Hypertension Arsenic 5.649931084 11953799 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.6418850075 18670907
MESH:D006987 Hypesthesia Arsenic 6.2816093927
MESH:D007248 Infertility, Male vinclozolin 3.2916467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007642 Keratosis Arsenic 5.6212749816 16930632
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7917339181
MESH:D007984 Leydig Cell Tumor vinclozolin 5.3616417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2312878042
MESH:D008107 Liver Diseases Arsenic 2.6111134558
MESH:D008113 Liver Neoplasms Arsenic 8.1216368122
MESH:D008113 Liver Neoplasms pirinixic acid 8.1216377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.1216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Arsenic 2.5119168569 17976673 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.5111884234 19555203
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D017202 Myocardial Ischemia Arsenic 10.1015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 10.1012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D009436 Neural Tube Defects Arsenic 3.6916620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.8417056641
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.8417306315
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.6816093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.6216905509 6392382 15371236
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.6811222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.6818042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.5718220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.5516140617
MESH:D011472 Prostatitis vinclozolin 5.5718629315
MESH:D011507 Proteinuria Arsenic 4.4721343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012871 Skin Diseases Arsenic 2.8216702368 16759981 6392382 19834688 17453740 15952646 18709164 16353154 17548696 17938729 17050553
MESH:D012878 Skin Neoplasms Arsenic 6.2417029826 17050553 19538983 15504454 16251483 17976673
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.2416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.9411144890 15987713 19322015 18640142 17976673 19429237 17306315
MESH:D014652 Vascular Diseases Arsenic 5.3717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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