AutismKB 2.0

Annotation Detail for PRMT7


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Basic Information Top
Gene Symbol:PRMT7 ( FLJ10640,KIAA1933 )
Gene Full Name: protein arginine methyltransferase 7
Band: 16q22.1
Quick LinksEntrez ID:54496; OMIM: 610087; Uniprot ID:ANM7_HUMAN; ENSEMBL ID: ENSG00000132600; HGNC ID: 25557
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of PRMT7 mRNAincreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of PRMT7 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in decreased expression of PRMT7 mRNAdecreases expression 20106945
D004317 Doxorubicin Doxorubicin affects the expression of PRMT7 mRNAaffects expression 15699352
D004317 Doxorubicin PRMT7 protein results in decreased susceptibility to Doxorubicindecreases response to substance 15699352
D004958 Estradiol [Progesterone co-treated with Estradiol] affects the expression of PRMT7 mRNAaffects cotreatment|affects expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PRMT7 mRNAaffects expression 17555576
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRMT7 mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] affects the expression of PRMT7 mRNAaffects cotreatment|affects expression 17404688
D013629 Tamoxifen Tamoxifen affects the expression of PRMT7 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.3517418594
MESH:D000230 Adenocarcinoma Estradiol 7.3511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000419 Albuminuria Doxorubicin 4.7821441931
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0214601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15380490 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 4.0017150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0116115903 15692762 15668708 16826403 15136595 15994142 11325840 15993339 17983394 15567936 16096432 18382427 19526202 18695136 15939500 15634643 18628466 16595493 17369602 17426702 18234424 16322301 16264153 16935488
MESH:D001943 Breast Neoplasms Estradiol 2.0118497071 12948864 17018787 19861407 17289903 16675129 14630087 17261762
MESH:D001943 Breast Neoplasms Progesterone 2.0115562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 2.0119221464 18984771 19155303 17049068 11161223 19189210 18855134 18815881 19115204 17893378 18629630 17242785 18351453 19011961 15565566 19084267 19244106 16873071 16202921 21152245 20544844 19289846 15668708 19059307 19103187 20859285 19142967 19189212 20135344 20065188 16273361 19410462 18821012 18997820 21138602 19200415 16818667 18425577 19066611 20390343 17440819 17261762 20005174 19487384 19288272
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1316051944
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.173084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.1716234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1716924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1716924424
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.241485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.686189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D009202 Cardiomyopathies Doxorubicin 3.6615505089 16455267 17351982 17382496 17007740 16731534 17519947 16651473 16364871 17974986 17308081 15792986 16109756 15811867 16269455 16612575 15476868 16952015 17329180 16242529 17131338 16278810 18627295 17924179 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0016243910 17334414
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.956135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9518566989
MESH:D002779 Cholestasis Cyclosporine 14.2319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2317681005 16919318 17333356 17110522 11677210 16105132 15861022
MESH:D002779 Cholestasis pirinixic acid 14.2319176532
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003928 Diabetic Nephropathies Estradiol 9.4619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5519164858 18713872 16781746 19739265 14725611 11287661 16109766 10774834 11421492 19923254 17522070 2444490 12705907 12540782 16227642 11529661 12958197 10915739 19085960 15619225 15968718 12153990 16177239 17906064 18071297 14550746 11461765 19420014 17562736 10663392 19370779 11739529 16393943 11743745 12594235 12392966 16485898 16081117 11834606 19416960 14986274
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.5517416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.8218602426
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.7719031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 13.2217359293
MESH:D016889 Endometrial Neoplasms Estradiol 13.2219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 13.2217893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.4718037988
MESH:D005234 Fatty Liver Cyclosporine 20.5219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5215345470
MESH:D005234 Fatty Liver pirinixic acid 20.5219236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 20.5214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 12.4119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 12.4119069698
MESH:D005355 Fibrosis Cyclosporine 3.4012168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Doxorubicin 3.4717150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6615692506
MESH:D006331 Heart Diseases Doxorubicin 3.6216330681 16244371 18006777 16144979 14766674 18674790 12587719 16244372 16879835 16707910 16495754 17875725 17888722
MESH:D006333 Heart Failure Doxorubicin 7.4517481944
MESH:D006333 Heart Failure pirinixic acid 7.4520558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1115692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 19772884 18467677 19176532
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.5915147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Progesterone 5.4915869954
MESH:D007249 Inflammation Tamoxifen 5.4919457130
MESH:D007333 Insulin Resistance Estradiol 7.6216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 15.3512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 15.3518776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 15.3515699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 15.3515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.3616707910
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 19.2212371664
MESH:D007680 Kidney Neoplasms Estradiol 19.2215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 19.2218625569
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.4716085563
MESH:D008064 Lipidoses Tamoxifen 3.3017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 5.1316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1318564211
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 12969438 12587719 19014921 19784758 19460945 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.797678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.7920007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.7916684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.476135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.4717085340 16842330
MESH:D008175 Lung Neoplasms Doxorubicin 2.636189445 17418594
MESH:D008175 Lung Neoplasms Tamoxifen 2.6318625569
MESH:D008223 Lymphoma Doxorubicin 3.6016098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8315621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 15.3515458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.3511408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.3517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 15.3514580682 11731420 16827153 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 13.7319453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.7319453300
MESH:D008545 Melanoma Doxorubicin 3.5116827129
MESH:D008545 Melanoma Tamoxifen 3.5112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Doxorubicin 3.1317638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7015792986
MESH:D052016 Mucositis Doxorubicin 5.0817415656
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.9615857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.9619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.7816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.7816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.1518551238 7678174
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.1118259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.1119393235
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009401 Nephrosis Doxorubicin 5.0316899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.9119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.9115640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 3.8911399458 16427766
MESH:D009447 Neuroblastoma Doxorubicin 3.3615555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6216049721
MESH:D012516 Osteosarcoma Doxorubicin 4.2815930896
MESH:D010051 Ovarian Neoplasms Estradiol 5.0519401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.0516525653 17393432
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.4717983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.4717638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5416868541 18437689 16888761 16729912 15749863 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.4817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012509 Sarcoma Doxorubicin 4.1817203757 18313854 17710206 16767912 15675481 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4816326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.0817846226
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6718551238
MESH:D012878 Skin Neoplasms Doxorubicin 3.0315692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8317203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.8415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.8419457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5216010429 17909728
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.7717653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7716712894 17572228 8653321
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4816364871 17678736 17334414 17638931
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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