AutismKB 2.0

Annotation Detail for ATR


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Basic Information Top
Gene Symbol:ATR ( FRP1,MEC1,SCKL,SCKL1 )
Gene Full Name: ataxia telangiectasia and Rad3 related
Band: 3q23
Quick LinksEntrez ID:545; OMIM: 601215; Uniprot ID:ATR_HUMAN; ENSEMBL ID: ENSG00000175054; HGNC ID: 882
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
hsa04115p53 signaling pathway
Pathway IDPathway Name
DNA Repair
Cell Cycle Checkpoints
Pathway IDPathway Name
200068Circadian rhythm pathway
200065Signaling events mediated by TCPTP
200174BARD1 signaling events
200175p53 pathway
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00059p53 pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00037Alveolar rhabdomyosarcoma
Cancers of soft tissues and bone
Desease IDDesease Name
1720Fanconi's anemia
1934Cancer
Desease Name
Microsatellite Instability
CANCER
Endometrial Neoplasms
Carcinoma, Endometrioid
No data
Desease Name
Seckel syndrome 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C031278 2-chloroethyl ethyl sulfide ATR protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]affects reaction|increases phosphorylation 19111594
C031278 2-chloroethyl ethyl sulfide ATR protein affects the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]affects reaction|increases phosphorylation 19111594
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ATR mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of ATR mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased activity of ATR proteinincreases activity 16891316
C006632 arsenic trioxide arsenic trioxide results in increased activity of ATR proteinincreases activity 16891316
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATR mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ATR mRNAdecreases expression 12419474
C074702 chromium hexavalent ion chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]increases phosphorylation|increases reaction 16876463
C074702 chromium hexavalent ion chromium hexavalent ion results in increased activity of ATR proteinincreases activity 16876463
C074702 chromium hexavalent ion RAD17 protein affects the reaction [chromium hexavalent ion promotes the reaction [ATR protein results in increased phosphorylation of SMC1A protein]]affects reaction|increases phosphorylation|increases reaction 16876463
C014347 decitabine ATR protein affects the reaction [decitabine results in increased expression of TP53 protein]affects reaction|increases expression 17977830
C014347 decitabine decitabine affects the localization of ATR protein modified formaffects localization 17991895
C014347 decitabine decitabine promotes the reaction [ATR protein results in increased phosphorylation of TP53 protein]increases phosphorylation|increases reaction 17977830
C014347 decitabine decitabine results in increased activity of ATR proteinincreases activity 17977830
C014347 decitabine RPA1 protein affects the reaction [decitabine results in increased activity of ATR protein]affects reaction|increases activity 17977830
D004052 Diethylnitrosamine ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR mRNA]decreases reaction|increases expression 19919837
D004052 Diethylnitrosamine ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATR protein]decreases reaction|increases expression 19919837
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ATR mRNAincreases expression 19919837
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ATR proteinincreases expression 19919837
D017953 Isocyanates Isocyanates results in increased expression of ATR proteinincreases expression 19283680
D015741 Metribolone Metribolone promotes the reaction [AR protein binds to ATR promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone promotes the reaction [UXT protein binds to ATR promoter]affects binding|increases reaction 19318562
D015741 Metribolone Metribolone results in increased expression of ATR mRNAincreases expression 19318562
C006253 pirinixic acid pirinixic acid results in increased expression of ATR mRNAincreases expression 18301758
17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ATR mRNA]increases expression|increases reaction 17950772
D012402 Rotenone Rotenone results in increased expression of ATR mRNAincreases expression 18191903
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3011798837 19825857
MESH:D000236 Adenoma Diethylnitrosamine 2.896695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.4919052882 16434500 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4916434500
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1510965797
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.2716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2719483382
MESH:D001943 Breast Neoplasms decitabine 2.2818320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2817474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.613084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6115553829 16217749 14691202 15073043 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.6119701751 18971187 17173139 3581430 16288022 19383236 10672840 18665156 17978847 19335982 19539802 17428255 17138121 21159647 19171122 18785209 20727157 20524982 17055752 20935162 18506893 16807293 16502159 11831363 16878318 20007298 18788625 16779866 16328049 20084675 20514400 19394651 16681979 18210153 16935385 17761372 16830150 19519916 18691550 3084413 20432363 19822196 16540662 10737359 16698587 20512989 19208518 19418558 18056438 18393292 19919837 19052882 18978308 19107877 20214788 17162532 20101231 16569478 18494052
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8620889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.867505956 21159647 2727394 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6020501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6018981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8219739265 11739529 12153990 19420014 10915739 12540782 10663392 18713872 16781746 19164858 14725611 12594235 11287661 14550746 12705907 11529661 17906064 15619225 19370779 11743745 12392966 2444490 17562736 19923254 16485898 18071297 17522070 16109766 16227642 10774834 16177239 14986274 11834606 11461765 16393943 19085960 12958197 11421492 15968718 19416960 16081117
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.8219107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5212903497
MESH:D005234 Fatty Liver arsenic trioxide 13.5915073043
MESH:D005234 Fatty Liver Diethylnitrosamine 13.5921071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 13.5919236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1018467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D007248 Infertility, Male decitabine 3.2517581917
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007333 Insulin Resistance pirinixic acid 2.6816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007938 Leukemia arsenic trioxide 6.5815070760
MESH:D007938 Leukemia decitabine 6.5819235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.8619077051
MESH:D007951 Leukemia, Myeloid decitabine 9.8619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0416968895 16467208 17050201 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0417679729 18206229 18704418 19387464 18460780 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2616823087 12018890 15213294 19225113 17649720 17217047 19075265 16966277 16891316 12679006 15622746 11161223 16331271 17869043 19642359 15336539 12712474 17712046 11468182 16112521 9834237 17107899 19035177 15748426 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8718407596 19638242 20032147 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 3.9711587558 12969438 19784758 19014921 12587719 16610002 19460945 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 7.5914682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.5919850985 21167192 18754104 20501860 2422723 19255062 19256749 19642983 21047994 18977376 18978307 20101389 20452335 21071580 19090486 2862719 18644402 15175105 20118626 19996281 10737359 15885732 9163691 18648771 20492335 20583210 20405173 19254457 20434301 19499222 19073162 19294768 19551842 12771043 19812893 20137499 16942905 12112319 19833225 19690152 19427195 19426721 21278145 19638242
MESH:D008113 Liver Neoplasms pirinixic acid 7.5915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1620377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.1618164116 19009564 18253720 19539802 3124819 16267830 17942915 18308698 18544905 16842330 17174075 19519916 21159647 9362446 18079962 18282651 17854601 19004024 2563599 18775883 19126423 18093689
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases 2-chloroethyl ethyl sulfide 8.6912815614 18675330 16252256
MESH:D008171 Lung Diseases chromium hexavalent ion 8.6916775837
MESH:D008175 Lung Neoplasms arsenic trioxide 3.7211798837 19825857
MESH:D008175 Lung Neoplasms chromium hexavalent ion 3.7216876463 16570259
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.7220512841 20970405 21163286 6695378
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5714977855 11468182 19417148 19549372 15949261
MESH:D009101 Multiple Myeloma decitabine 7.5718172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6516105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6519010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D009369 Neoplasms decitabine 5.1519470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009410 Nerve Degeneration Rotenone 3.9417356569 18619942 15790535
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D009669 Nose Neoplasms chromium hexavalent ion 5.2316876463
MESH:D009765 Obesity 2-chloroethyl ethyl sulfide 5.0616289378
MESH:D009765 Obesity pirinixic acid 5.0620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0612452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms decitabine 5.0619259094 19331143
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8115580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.8119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.8116540662
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010300 Parkinson Disease Rotenone 3.0019114014 11445065 18191903 11535288 15451049 19232380 16140633 18619942 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.1515574749 18197244 15927086 15795934
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.6411550810
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012128 Respiratory Distress Syndrome, Adult 2-chloroethyl ethyl sulfide 5.1918257742 16292752 12210543
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:C537533 Seckel syndrome 1 marker/mechanism
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4517007042
MESH:D013274 Stomach Neoplasms decitabine 3.4519037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4518456281
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.3919014326
MESH:D013964 Thyroid Neoplasms decitabine 12.3917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.397505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3412845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3417616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:216 DNA Repair
KEGG:04115 p53 signaling pathway
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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