AutismKB 2.0

Annotation Detail for POU2F1


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Basic Information Top
Gene Symbol:POU2F1 ( OCT1,OTF1 )
Gene Full Name: POU class 2 homeobox 1
Band: 1q24.2
Quick LinksEntrez ID:5451; OMIM: 164175; Uniprot ID:PO2F1_HUMAN; ENSEMBL ID: ENSG00000143190; HGNC ID: 9212
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transcription
Pathway IDPathway Name
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200159Calcium signaling in the CD4+ TCR pathway
200077Glucocorticoid receptor regulatory network
200116ATF-2 transcription factor network
200102Regulation of Androgen receptor activity
200194FOXA1 transcription factor network
No data
Pathway IDPathway Name
500583RNA Polymerase III Transcription Initiation From Type 3 Promoter
500579RNA Polymerase III Abortive And Retractive Initiation
Related Diseases/Disorders Top
No data
No data
Desease Name
Alzheimer's disease
plasma levels of liver enzymes
NEUROLOGICAL
METABOLIC
Desease Name
Plasma levels of liver enzymes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of POU2F1 mRNAaffects expression 18281256
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of POU2F1 mRNAincreases expression 18648102
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of POU2F1 mRNAdecreases expression 17023530
D015081 2-Naphthylamine 2-Naphthylamine results in increased expression of POU2F1 mRNAincreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POU2F1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of POU2F1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of POU2F1 mRNAincreases expression 18247414
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNAdecreases expression 19925653
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of POU2F1 mRNAdecreases expression 11566570
D000431 Ethanol Ethanol results in decreased expression of POU2F1 mRNAdecreases expression 11566570
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of POU2F1 mRNAdecreases expression 17108234
D015759 Ionomycin [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of POU2F1 proteinaffects cotreatment|increases activity 16241859
D008713 Methimazole Methimazole results in increased expression of POU2F1 mRNAincreases expression 17399805
D009538 Nicotine Nicotine results in increased expression of POU2F1 mRNAincreases expression 18247414
D010126 Ozone Ozone results in decreased expression of POU2F1 mRNAdecreases expression 12763052
C494474 perchlorate perchlorate results in increased expression of POU2F1 mRNAincreases expression 17399805
D010634 Phenobarbital Phenobarbital results in decreased expression of POU2F1 mRNAdecreases expression 16837569
D011441 Propylthiouracil Propylthiouracil results in increased expression of POU2F1 mRNAincreases expression 17399805
D012293 Rifampin Rifampin results in decreased expression of POU2F1 mRNAdecreases expression 16837569
D014284 Triiodothyronine Triiodothyronine affects the expression of POU2F1 mRNAaffects expression 17403546
D013974 Thyroxine Thyroxine affects the expression of POU2F1 mRNAaffects expression 17403546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of POU2F1 mRNAdecreases expression 20106945
16837569
D013755 Tetradecanoylphorbol Acetate [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of POU2F1 proteinaffects cotreatment|increases activity 16241859
D014212 Tretinoin Tretinoin promotes the reaction [POU2F1 protein binds to SPI1 promoter]affects binding|increases reaction 16352814
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 13.2518926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.256195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.2511752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.8918287403
MESH:D000138 Acidosis Ethanol 9.8911192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7711798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.273712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.276695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.5117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5116835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1515451039 15451040
MESH:D000505 Alopecia Tretinoin 3.4815955085
MESH:D000544 Alzheimer Disease Nicotine 4.5116627626
MESH:D000544 Alzheimer Disease Ozone 4.5115513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000853 Anophthalmos Ethanol 4.6515513904
MESH:D001008 Anxiety Disorders Ethanol 3.8711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.8615885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.8616412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.5315570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5316292516
MESH:D001249 Asthma Ozone 4.7816373670 17854713
MESH:D001249 Asthma Tretinoin 4.7816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.2416935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8511289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.7216206674
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 20.7219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.7212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.7216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8117474063 20146248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8116166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5414754758 18315731 16777450 15516495 18417511 17626835 19059883
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002056 Burns Ethanol 4.4816374292
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6116050911 16227642 18705752 3786805 16011737 15673190 16124888 15721981 16097048 15700767 16192424 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9916168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.037296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.0315073043 11135700 15553829 14691202 16217749
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0318788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.0315763234 18788625 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.031701930 6705139 20007298 20935162 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.031917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.607296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2920419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.2918922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2916051514 16096774
MESH:D006332 Cardiomegaly Ethanol 11.0219332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.0218670907 18850075 16120746
MESH:D006332 Cardiomegaly Thyroxine 11.0218093424
MESH:D002386 Cataract Tretinoin 2.9917460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.647505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4216129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.449022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4417681005 17110522 16919318 15861022 11677210 17333356 16105132
MESH:D002822 Choriocarcinoma Tretinoin 4.9916461808
MESH:D002971 Cleft Lip Ethanol 3.5015513904
MESH:D002972 Cleft Palate Ethanol 9.4315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.4312621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 9.439407595
MESH:D003092 Colitis Tretinoin 3.5317035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9114669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.2610525206
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2615513904 11198716 15451040 19302082 11873399 15451039 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2620055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.2616925845 17551590 9211117 10589399 9224671 9125849 9664655 14991402 8800419 9142499
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6412868966 8156756 18759878 11906362 8970840 2524372 11298694 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.333621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.5618648102 16192314 9653073 11289319 18289764 7440962 18692083 6679447 9022650 8291058 1440618 6482804 9328219
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.5611566570 19085960 7179309 15968718 10092053 16227642 2869522 9327722 15027814 10915739 6884620 3732212 19336974 7440962 7120509 3786805 15998439 17522070 6623471 4309450 21278145 16177239
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.5611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:D020821 Dystonic Disorders Nicotine 5.7517881519
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4411000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.448113982 15177302 16716910 11698051 8273558 9599246 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.3715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.3718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.879294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.703922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.043581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.0412903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.0416530937
MESH:D004938 Esophageal Neoplasms Ethanol 10.0416704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.4116938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 17.5215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.5212795759 19224547 15959796 16045604 17595544 12631006 61145 16239168
MESH:D005234 Fatty Liver Ethanol 17.5219236843 16409862 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.5215345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1316946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.856705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.7718705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.7720067830
MESH:D005355 Fibrosis Tretinoin 13.7717994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005756 Gastritis Ethanol 4.5215046732
MESH:D005909 Glioblastoma Tretinoin 2.9017312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 10.947505956
MESH:D006042 Goiter perchlorate 10.9418801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.579664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.676705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6719110552 19900420
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 13.6316109766
MESH:D006529 Hepatomegaly Phenobarbital 13.6316109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.6316120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8718606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Ethanol 7.5518783367
MESH:D006930 Hyperalgesia Tretinoin 7.5516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4016778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7715034207
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3617604070
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8418670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006980 Hyperthyroidism Methimazole 5.4514678291
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D007037 Hypothyroidism Methimazole 11.3818031379
MESH:D007037 Hypothyroidism Propylthiouracil 11.388137927 18031379
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8712200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 4.877562506 8273558 7812673 15177302 11698051
MESH:D007410 Intestinal Diseases Tretinoin 3.6017994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.858074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 16.2815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 16.2816580747
MESH:D007569 Jaw Abnormalities Tretinoin 16.2817551590 15992940
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.836582329
MESH:D007859 Learning Disorders Ethanol 4.0415451040
MESH:D007938 Leukemia arsenic trioxide 6.0615070760
MESH:D007938 Leukemia Tretinoin 6.0617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7720471514 16968895 17050201 16467208 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2619642359 15622746 19035177 16331271 16891316 17869043 15213294 12018890 16966277 16330433 19225113 17712046 9834237 15748426 16112521 17107899 11468182 12679006 19075265 12712474 17649720 17217047 11161223 15336539 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2617368321 12679006 17301526 17506722 17712046 19035177 19642359 17361223 19029980 19075265 17107899 16823087 16140955 17649720 16935935 9834237 16331271 16788101 16766008 17294898 17339181 16891316 17217047 19225113 15748426
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D017880 Limb Deformities, Congenital Ethanol 7.9117676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.919224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.5516221502 16239168 16943688 17157831 11408273 11903743 21278145 17174718 17334410
MESH:D008103 Liver Cirrhosis Ethanol 10.5515289165
MESH:D008103 Liver Cirrhosis Phenobarbital 10.5521047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9218295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.099327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8016136751 16011737 18277467 12741479 17823541 17631135 16248980 17525996 12389079 12667390 18472332 12958196 17805973 18418968 18210741 15996030 16015684 18420326 18006644 15876570 12632514 11481614 15370692 18481824 15893842 15818738 15730626 18376398 15931870 12445421 17698563 17640975 17557913 18395095 16116963 12609069 14620537 17766677 15650968 17761835 12445418 17714472 15338365 15362042 16638106 16027843 12666154 18429990 17922224 18156304 14512876 18187930 18395914 12586293 12898905 14716833 14748882 18263696 18054572 17944888 17869086 15959796 18472094 20821823 17481882 16192424 18317297 18166357 12546737 16097048 17708605 14724832 17976157 17900296 17565644 18279442 15052691 18705752 15925388 15057751 18412020 10355542 12649538 17721639 15673190 16033810 14716496 12632512 18339082 18251166 18205269 13678700 15123356
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.8018166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8018397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9516246199 15830285 16964402 17285989 15720792
MESH:D008107 Liver Diseases Phenobarbital 3.9519363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4817207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5414706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 17.1414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.1420195826 21137059
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 17.1418177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.1419294768
MESH:D008113 Liver Neoplasms Phenobarbital 17.148742319 19812893 19073162 19482888 21047994 15975961
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.1416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.511399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.5120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.5112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.511399818 2563599 18308698 17172636 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008171 Lung Diseases Ozone 3.2619066396 8266340
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms arsenic trioxide 8.2819825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2817053015 20464547 18520028 18816296 20135361 20064080 6695378 20869020 18569708
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 8.2819359593 16337739 11246140 15390079 11696405 18597497 19925653
MESH:D008175 Lung Neoplasms Ozone 8.288597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.2811807781
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 5.9611422169
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 3.9311422169
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 6.311500032
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.318985016
MESH:D008527 Medulloblastoma Tretinoin 2.7217453147
MESH:D008545 Melanoma Tretinoin 1.9216752155
MESH:D008569 Memory Disorders Ethanol 4.0215451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.2516940565
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9814977855 15949261 19417148 11468182 19549372
MESH:D009164 Mycobacterium Infections Rifampin 5.3818474467
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.0716882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8812213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7916624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.403581430
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9211141357
MESH:D009369 Neoplasms Nicotine 7.9216365874
MESH:D009369 Neoplasms Tretinoin 7.9216594593 16946489
MESH:D009389 Neovascularization, Pathologic Nicotine 4.8216365874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 8.969125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.486679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.4810525206
MESH:D009436 Neural Tube Defects Tretinoin 11.489142499
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.274026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.853988306
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6912452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6916936753
MESH:D010146 Pain Tretinoin 2.7716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 15.6815580305
MESH:D010190 Pancreatic Neoplasms Ethanol 15.6812384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 15.6816965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 15.6815976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 15.6815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.837296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.8312065085 18922899 8330346 18404319
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.306228378
MESH:D011014 Pneumonia Butylated Hydroxytoluene 10.7511893704
MESH:D011014 Pneumonia Ozone 10.7518381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.482563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2419131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011507 Proteinuria Tretinoin 3.4416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1415861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D011625 Pterygium Tretinoin 4.6216723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.253692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9416116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7916646077
MESH:D012640 Seizures Ethanol 9.399754883
MESH:D012640 Seizures Nicotine 9.3917873105
MESH:D012640 Seizures Phenobarbital 9.3916876388 11442880 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9210029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9216192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.928330346 11807781 18404319 12065085 8985016
MESH:D012878 Skin Neoplasms Tretinoin 12.9216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5917007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5920155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 4.5918456281
MESH:D013274 Stomach Neoplasms Tretinoin 4.5917261132
MESH:D013276 Stomach Ulcer Ethanol 3.389562338 16755016 9211565 11906479 17189318 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.109754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.8012697716
MESH:D013959 Thyroid Diseases Thyroxine 11.8019910387
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 21.091399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 21.0919014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 21.091399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 21.0915710170
MESH:D013964 Thyroid Neoplasms Tretinoin 21.0916026305 17045167
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6016720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.2817979512 18305452 15735609 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 3.6416051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D014376 Tuberculosis Rifampin 8.0815236969 18397238
MESH:D014376 Tuberculosis Tretinoin 8.0816040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 11.4311144890
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.438074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.4312973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4317053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5316129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.8916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D009396 Wilms Tumor Tretinoin 3.8216287080
Pathway ID Pathway Name
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33536
    • Releated gene ID Related gene Name
    PA30696MCM6
    PA28554GAPDH
    PA36380HNF1A
    No data
    Releated drug ID Related drug Name
    PA451578tacrolimus
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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