AutismKB 2.0

Annotation Detail for PCDH18


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Basic Information Top
Gene Symbol:PCDH18 ( DKFZp434B0923,KIAA1562,PCDH68L )
Gene Full Name: protocadherin 18
Band: 4q28.3
Quick LinksEntrez ID:54510; OMIM: 608287; Uniprot ID:PCD18_HUMAN; ENSEMBL ID: ENSG00000189184; HGNC ID: 14268
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00012Cadherin signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PCDH18 mRNAdecreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in decreased expression of PCDH18 mRNAdecreases expression 20713471
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PCDH18 mRNAdecreases expression 20713471
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of PCDH18 mRNAdecreases expression 20713471
D010126 Ozone Ozone results in decreased expression of PCDH18 mRNAdecreases expression 19555225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PCDH18 mRNAdecreases expression 19933214
D013752 Tetracycline Tetracycline results in increased expression of PCDH18 mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 11752688 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.366695378
MESH:D000236 Adenoma Methylcholanthrene 7.3610545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7016373670 17854713
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6011922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0311921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0317474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0317474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9018417511 14754758 15516495 19059883 18315731 17626835 16777450
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002277 Carcinoma Methylcholanthrene 9.0810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.0816835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 3.6816192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 8697196 15340226 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.2720420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 4.2717522070
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3515322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Tetracycline 4.3319224547 16917069
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.3414633661 10962813
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.6221137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6216984957
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.54598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5412151625
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0818816296 20064080 20464547 20869020 20135361 17053015 6695378 18520028 18569708
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.086695378 16337739 17909032 1399818 21163286 7750092 11893704 20512841 20970405 9230183 15390079 16271038 10545420
MESH:D008175 Lung Neoplasms Ozone 5.087614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0811884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.7411921183
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009395 Nephritis, Interstitial Tetracycline 5.239884423
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.8811026799
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911399792 11222880 11118676 11896295
MESH:D017096 Prion Diseases Tetracycline 5.8110903871
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9317292933
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8519755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33002
    • No data
    Releated disease ID Related disease Name
    PA445218Pancreatic Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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