AutismKB 2.0

Annotation Detail for MTRF1L


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Basic Information Top
Gene Symbol:MTRF1L ( MGC102748,MRF1L,mtRF1a )
Gene Full Name: mitochondrial translational release factor 1-like
Band: 6q25.2
Quick LinksEntrez ID:54516; OMIM: 613542; Uniprot ID:RF1ML_HUMAN; ENSEMBL ID: ENSG00000112031; HGNC ID: 21051
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MTRF1L mRNAaffects expression 17562736
C014347 decitabine decitabine results in increased expression of MTRF1L mRNAincreases expression 19194470
C009131 pyrimidin-2-one beta-ribofuranoside pyrimidin-2-one beta-ribofuranoside results in increased expression of MTRF1L mRNAincreases expression 19194470
D018038 Sodium Selenite Sodium Selenite results in decreased expression of MTRF1L mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms decitabine 2.5318320071 19208741
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6819215824
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D019457 Chromosome Breakage Sodium Selenite 5.3115894690
MESH:D003110 Colonic Neoplasms decitabine 2.3817616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1118981723
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1516285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1414550746 17906064 18713872 16109766 16485898 16781746 11739529 11461765 19370779 16177239 12392966 19164858 12594235 15968718 10915739 19085960 10663392 11834606 12540782 17522070 15619225 19420014 18071297 11421492 11529661 19739265 19923254 14986274 10774834 16081117 17562736 14725611 12153990 12958197 2444490 16227642 16393943 19416960 12705907 11287661 11743745
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1415131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.8419294695
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.7419215824
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007248 Infertility, Male decitabine 3.4517581917
MESH:D007333 Insulin Resistance Sodium Selenite 3.5214714311
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007938 Leukemia decitabine 3.2419235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.4319117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4318206229 17679729 19010910 18460780 19387464 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.1918055864
MESH:D008107 Liver Diseases Acetaminophen 1.7012969438 16611625 19460945 16610002 19014921 12587719 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008223 Lymphoma decitabine 3.6919470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5214737004
MESH:D008545 Melanoma decitabine 4.2517785578 16505122
MESH:D008545 Melanoma pyrimidin-2-one beta-ribofuranoside 4.2516505122
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009101 Multiple Myeloma decitabine 3.6218172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5818608210 19010910 16882708 19157545
MESH:D009369 Neoplasms decitabine 2.8719470736 17925555 19116145
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms decitabine 2.7419259094 19331143
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8719294695
MESH:D055728 Primary Myelofibrosis decitabine 5.2917616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3318760546
MESH:D012208 Rhabdomyosarcoma decitabine 4.8719155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.6317967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8417616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D014604 Uveal Neoplasms decitabine 5.6417785578
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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