AutismKB 2.0

Annotation Detail for MRPL50


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Basic Information Top
Gene Symbol:MRPL50 ( FLJ20493,FLJ21990,MRP-L50 )
Gene Full Name: mitochondrial ribosomal protein L50
Band: 9q31.1
Quick LinksEntrez ID:54534; OMIM: 611854; Uniprot ID:RM50_HUMAN; ENSEMBL ID: ENSG00000136897; HGNC ID: 16654
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MRPL50 mRNAaffects expression 17562736
C006253 pirinixic acid pirinixic acid results in decreased expression of MRPL50 mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MRPL50 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.5914514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.6418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 12.5116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 12.5116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3911748828
MESH:D000799 Angioedema Acetaminophen 4.7110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.4219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0215746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5816120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.8110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5816835633
MESH:D002779 Cholestasis pirinixic acid 3.1519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2515668235 12621046 16354765 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2720055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8914986274 10663392 12392966 11743745 11461765 11739529 12958197 19420014 16081117 17906064 11287661 18713872 16177239 16485898 16227642 12153990 11834606 19164858 15619225 11529661 19085960 12540782 12705907 19370779 11421492 12594235 16109766 14550746 14725611 2444490 17522070 19923254 15968718 16393943 19739265 17562736 19416960 10915739 18071297 16781746 10774834
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.9619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0911462148
MESH:D004487 Edema pirinixic acid 8.1812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.1811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.7716714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4710568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3411564622
MESH:D005234 Fatty Liver pirinixic acid 3.2520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.1111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.6020067830
MESH:D005756 Gastritis Acetaminophen 4.5416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.4610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.7820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.8211000095
MESH:D006529 Hepatomegaly pirinixic acid 10.5319772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 10.5315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.918697196 16354765 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 3.0616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.6320558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0318670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0412200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.9016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.8216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.4215629191 12587719
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.7119460945 16610002 19014921 16611625 12969438 19784758 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.6916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6916984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 4.2219513568
MESH:D009135 Muscular Diseases pirinixic acid 4.1616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2916411023
MESH:D009369 Neoplasms pirinixic acid 2.1217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.8014600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2618514411
MESH:D009765 Obesity pirinixic acid 1.8920558911
MESH:D010146 Pain Acetaminophen 2.7716870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 5.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.1418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.9311896295 11399792 11118676 11222880
MESH:D015427 Reperfusion Injury pirinixic acid 2.5619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.4218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2116192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.7712697716
MESH:D014581 Urticaria Acetaminophen 3.5010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.4612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 5.1215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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