AutismKB 2.0

Annotation Detail for DDIT4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DDIT4 ( Dig2,FLJ20500,REDD-1,REDD1,RP11-442H21.1,RTP801 )
Gene Full Name: DNA-damage-inducible transcript 4
Band: 10q22.1
Quick LinksEntrez ID:54541; OMIM: 607729; Uniprot ID:DDIT4_HUMAN; ENSEMBL ID: ENSG00000168209; HGNC ID: 24944
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04150mTOR signaling pathway
No data
Pathway IDPathway Name
200080mTOR signaling pathway
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of DDIT4 mRNA]affects expression|affects reaction 19414516
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of DDIT4 mRNAaffects expression 21346803
D000082 Acetaminophen [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DDIT4 mRNAaffects cotreatment|increases expression 17093179
D000082 Acetaminophen Acetaminophen affects the expression of DDIT4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DDIT4 proteinaffects expression 20106945
C103505 AM 251 AM 251 results in increased expression of DDIT4 mRNAincreases expression 16500647
D000638 Amiodarone Amiodarone results in increased expression of DDIT4 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DDIT4 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of DDIT4 mRNAincreases expression 16704987
C015001 arsenite arsenite promotes the reaction [CEBPB protein binds to DDIT4 promoter]affects binding|increases reaction 16008523
C015001 arsenite arsenite promotes the reaction [ELK1 protein binds to DDIT4 promoter]affects binding|increases reaction 16008523
C015001 arsenite arsenite results in increased expression of DDIT4 mRNAincreases expression 16008523
C015001 arsenite GPX1 protein inhibits the reaction [arsenite results in increased expression of DDIT4 mRNA]decreases reaction|increases expression 16008523
C015001 arsenite SOD1 protein inhibits the reaction [arsenite results in increased expression of DDIT4 mRNA]decreases reaction|increases expression 16008523
C015001 arsenite arsenite results in decreased expression of DDIT4 mRNAdecreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in decreased expression of DDIT4 mRNA]affects reaction|decreases expression 18929588
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DDIT4 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DDIT4 mRNAdecreases expression 20382639
19150397
C095105 bexarotene bexarotene results in increased expression of DDIT4 mRNAincreases expression 17178900
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of DDIT4 mRNAincreases expression 17654400
D003520 Cyclophosphamide DDIT4 protein affects the susceptibility to Cyclophosphamideaffects response to substance 16217747
D016572 Cyclosporine Cyclosporine results in increased expression of DDIT4 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of DDIT4 mRNAincreases expression 17998272
D004040 Dietary Carbohydrates [Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of DDIT4 mRNAaffects cotreatment|increases expression 17093179
D004041 Dietary Fats Dietary Fats results in decreased expression of DDIT4 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DDIT4 mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of DDIT4 mRNAincreases expression 15289156
D004958 Estradiol Estradiol affects the expression of DDIT4 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in increased expression of DDIT4 mRNAincreases expression 19153601
D004958 Estradiol Estradiol results in increased expression of DDIT4 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of DDIT4 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of DDIT4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDIT4 mRNAaffects cotreatment|increases expression 17942748
D005047 Etoposide DDIT4 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil results in increased expression of DDIT4 mRNAincreases expression 16510598
17039268
16557594
C106014 gedunin gedunin results in increased expression of DDIT4 mRNAincreases expression 17010675
C056507 gemcitabine gemcitabine affects the expression of DDIT4 mRNAaffects expression 17039268
D019833 Genistein Genistein results in increased expression of DDIT4 mRNAincreases expression 15289156
D017313 Fenretinide Fenretinide results in increased expression of DDIT4 mRNAincreases expression 15958647
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of DDIT4 mRNAincreases expression 16008523
C475919 hydroxytamoxifen GPR30 protein affects the reaction [hydroxytamoxifen results in increased expression of DDIT4 mRNA]affects reaction|increases expression 19153601
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of DDIT4 mRNAincreases expression 19153601
C119620 kenpaullone kenpaullone results in decreased expression of DDIT4 mRNAdecreases expression 17993264
D015735 Mifepristone Mifepristone results in decreased expression of DDIT4 mRNAdecreases expression 17584828
D016685 Mitomycin DDIT4 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone DDIT4 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C042763 olive oil olive oil analog affects the expression of DDIT4 mRNAaffects expression 17349074
C055122 orlistat orlistat results in increased expression of DDIT4 mRNAincreases expression 18796435
D010126 Ozone Ozone results in increased expression of DDIT4 mRNAincreases expression 17460151
C041786 palm oil palm oil results in decreased expression of DDIT4 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DDIT4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of DDIT4 mRNAincreases expression 19482888
19270015
D010795 Phthalic Acids Phthalic Acids results in decreased expression of DDIT4 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of DDIT4 mRNAincreases expression 18445702
C025299 polyphenols polyphenols results in decreased expression of DDIT4 mRNAdecreases expression 16293270
D011374 Progesterone Progesterone results in increased expression of DDIT4 mRNAincreases expression 18037150
D011794 Quercetin Quercetin results in increased expression of DDIT4 mRNAincreases expression 19729006
D020849 Raloxifene Raloxifene affects the expression of DDIT4 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of DDIT4 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of DDIT4 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DDIT4 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DDIT4 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DDIT4 mRNAincreases expression 18691609
D019772 Topotecan DDIT4 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014212 Tretinoin Tretinoin results in increased expression of DDIT4 mRNAincreases expression 16054129
17379067
C034613 triacsin C triacsin C results in increased expression of DDIT4 mRNAincreases expression 16704987
C050414 tripterine tripterine results in increased expression of DDIT4 mRNAincreases expression 17010675
D015032 Zinc Zinc results in increased expression of DDIT4 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of DDIT4 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.466195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 6.4614514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 8.7818287403
MESH:D000138 Acidosis Zinc Sulfate 8.787265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.3817505938
MESH:D000169 Acrodermatitis Zinc 4.8517190629 16889938 17202136
MESH:D055371 Acute Lung Injury pirinixic acid 2.6118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 14.8020464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 14.8011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 14.8014692618
MESH:D000230 Adenocarcinoma Fenretinide 14.8010697514
MESH:D000230 Adenocarcinoma Fluorouracil 14.8017638652
MESH:D000230 Adenocarcinoma Genistein 14.8011473722
MESH:D000236 Adenoma Benzo(a)pyrene 5.486695378
MESH:D000236 Adenoma Diethylnitrosamine 5.4810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.3019052882 16434500 17162532 19061943 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.3017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.3016835633
MESH:D000419 Albuminuria Raloxifene 4.0717308373 17451421
MESH:D000505 Alopecia Tretinoin 3.1715955085
MESH:D000544 Alzheimer Disease Ozone 5.7915513908
MESH:D000544 Alzheimer Disease Raloxifene 5.7915800139
MESH:D000544 Alzheimer Disease Zinc 5.7916410023 16325427 16580781 17119284
MESH:D000686 Amyloidosis Diethylstilbestrol 3.9515469931
MESH:D000740 Anemia Fluorouracil 7.0716511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.0711748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7417084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.3716916123
MESH:D000799 Angioedema Acetaminophen 3.2810982225
MESH:D000860 Anoxia Zinc Sulfate 4.467265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.5319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.3220041841 18218290 18057881
MESH:D001161 Arteriosclerosis Cyclophosphamide 13.9315014928
MESH:D001161 Arteriosclerosis Dietary Fats 13.9315238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 13.9311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 10.1717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 10.1715885639
MESH:D001169 Arthritis, Experimental Tretinoin 10.1716412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1216292516
MESH:D001249 Asthma Ozone 6.7816373670 17854713
MESH:D001249 Asthma Tretinoin 6.7816456186
MESH:D001249 Asthma Zinc 6.7817085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4215336622
MESH:D050197 Atherosclerosis olive oil 3.9916216721
MESH:D001281 Atrial Fibrillation Amiodarone 3.4819698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 3.9720106747
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2418582451
MESH:D001327 Autoimmune Diseases Quercetin 3.8719761891
MESH:D001471 Barrett Esophagus Tretinoin 3.8716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 17.8719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.8719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.8712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 17.8716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.3915746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.5914601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7717868700
MESH:D001930 Brain Injuries Progesterone 15.3215380490 15845082 15665606
MESH:D001930 Brain Injuries Raloxifene 15.3216580743
MESH:D001930 Brain Injuries Zinc 15.3217109824
MESH:D001932 Brain Neoplasms Fenretinide 3.8716187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 17.8920146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 17.8916818667 16344269
MESH:D001943 Breast Neoplasms Cyclophosphamide 17.8915093573 17020986 18323546 17388661 12006526 18234424 16978400 11325840 15136595
MESH:D001943 Breast Neoplasms Dietary Fats 17.8920435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 17.8917474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 17.8917129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 17.8917289903 16675129 12948864 14630087 17261762 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Etoposide 17.8916322251
MESH:D001943 Breast Neoplasms Fenretinide 17.8916601279
MESH:D001943 Breast Neoplasms Fluorouracil 17.8916595493 16557594 19217205 18357371 15136595 16110121 18608205
MESH:D001943 Breast Neoplasms gemcitabine 17.8917039268 18382427
MESH:D001943 Breast Neoplasms Genistein 17.8916873071 16541309 17200150
MESH:D001943 Breast Neoplasms Progesterone 17.8917614352 16175315 15562024
MESH:D001943 Breast Neoplasms Quercetin 17.8918628248
MESH:D001943 Breast Neoplasms Raloxifene 17.8917242785 16912660 17893378 17595753 17440819 16837676 15775269 17049068 17261762 15572757 17952589 15758505
MESH:D001943 Breast Neoplasms Tamoxifen 17.8919142967 18855134 16202921 17893378 19059307 18815881 19103187 19189212 16273361 18629630 16818667 15565566 19200415 15668708 17440819 20859285 19066611 20544844 19487384 18351453 17049068 19221464 20065188 19189210 21152245 11161223 20390343 19011961 18997820 20135344 18984771 19155303 18821012 19288272 17261762 19115204 21138602 19084267 19289846 19410462 17242785 20005174 16873071 18425577 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 17.8920435547
MESH:D001943 Breast Neoplasms Tretinoin 17.8916873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2318417511 15516495 19059883 18315731 16777450 14754758 17626835
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0316813970
MESH:D019121 Burkholderia Infections orlistat 6.0717874328
MESH:D002100 Cachexia Ozone 4.1816183385
MESH:D002105 Cadmium Poisoning Quercetin 4.9816962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9116111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1016051944
MESH:D002277 Carcinoma Fluorouracil 6.7117121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.7116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 32.5616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 32.563084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 32.5621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 32.5619701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 32.5619919837 20524982 20514400 16540662 10672840 20727157 17173139 20935162 16288022 18691550 18506893 18494052 17055752 10737359 19539802 16569478 17978847 16698587 19171122 18971187 17138121 20101231 16878318 16830150 17761372 19107877 16502159 16681979 19208518 20214788 18788625 18665156 16328049 19418558 3581430 17162532 19701751 18056438 18210153 20512989 20084675 17428255 3084413 20432363 19394651 20007298 19052882 11831363 16807293 19383236 19519916 18978308 19335982 19822196 18785209 21159647 18393292 16935385 16779866
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 32.5615948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 32.5616924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 32.5617159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 32.5616332177 17088986 18930000 16799960 17045692 17971768
MESH:D006528 Carcinoma, Hepatocellular Genistein 32.5616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 32.5617173139 6705139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 32.5619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 32.5616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 32.561917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.3316152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0116247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4117234771
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 5.8416201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 5.8418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 12.2220419170
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 12.2216274795
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 12.2216757204 16280240 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 12.2216051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 12.2216543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.8917572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.8917572228
MESH:D006332 Cardiomegaly Quercetin 5.6919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.6918670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.6819225199 15710769
MESH:D002318 Cardiovascular Diseases Genistein 18.5516332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 18.5516936243
MESH:D002318 Cardiovascular Diseases olive oil 18.5516216721
MESH:D002318 Cardiovascular Diseases Raloxifene 18.5515775269
MESH:D002318 Cardiovascular Diseases Zinc 18.5516936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.5318974383
MESH:D002386 Cataract Acetaminophen 6.0610977129
MESH:D002386 Cataract Tretinoin 6.0617460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.7520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.7512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.7517174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.7518566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.714080065
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 11.1216154183
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 11.1216129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.7619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.7616835633
MESH:D002779 Cholestasis Cyclosporine 10.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 10.9016105132 15861022 11677210 17110522 17681005 17333356 16919318
MESH:D002779 Cholestasis pirinixic acid 10.9019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.5916461808
MESH:D002916 Chylothorax orlistat 6.0717003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 4.8815340226 8697196 12621046 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 4.889407595
MESH:D003072 Cognition Disorders Raloxifene 4.0715800139
MESH:D003092 Colitis Tretinoin 3.1717035595
MESH:D003110 Colonic Neoplasms arsenite 12.2915037631
MESH:D003110 Colonic Neoplasms Dexamethasone 12.2915824018
MESH:D003110 Colonic Neoplasms Fluorouracil 12.2917725105 17169374 15001691 17016597 16510598 17287894 17172411 18772588 17018589 16340194
MESH:D003110 Colonic Neoplasms Genistein 12.2917182828
MESH:D003110 Colonic Neoplasms polyphenols 12.2916293270
MESH:D003110 Colonic Neoplasms Quercetin 12.2919056647 17148506 17191121 19440933 15741050 11134977 16640504
MESH:D015179 Colorectal Neoplasms Fenretinide 3.2217273769
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2216303861 17094418 20501625 16391804 16524972 18448328 16331619 14970324 18509181 17255274 15148649 17695437 18383874 18802399 17454858 17594712 17401013 18949393 16282729 18288408 17016601 15289873
MESH:D015179 Colorectal Neoplasms Quercetin 3.2218095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.5917141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.7717728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.7710048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.7716925845 9211117 9224671 17551590 9125849 8800419 10589399 14991402 9142499 9664655
MESH:D019465 Craniofacial Abnormalities Zinc 4.7719302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0312952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.4718551238
MESH:D003556 Cystitis Cyclophosphamide 4.4217010015 18372110 18710439 16614059 16651033 18093676 17979934 16413132 16989017 18433785 11948286 12913760 10700343 12388444 12161096 15276878 18483878 15643279 18295254 10498854
MESH:D007644 Darier Disease Fluorouracil 4.2316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.6917474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9012438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1418249437
MESH:D048909 Diabetes Complications orlistat 5.2719207292
MESH:D003920 Diabetes Mellitus Zinc 3.7316479319
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.1515331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.1519496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0218772604
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.0916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.0917107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.3019279558
MESH:D003928 Diabetic Nephropathies Raloxifene 12.3015920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9517187935
MESH:D003967 Diarrhea Dexamethasone 6.887237001
MESH:D003967 Diarrhea orlistat 6.8820002075
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.5618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.5611739529 17906064 11743745 10915739 18713872 14725611 19420014 11461765 15619225 16227642 11529661 11421492 12594235 14550746 10663392 19085960 10774834 12705907 12392966 17522070 19164858 14986274 2444490 19739265 15968718 12153990 19370779 19416960 17562736 11834606 16485898 12540782 16393943 11287661 16109766 16781746 19923254 12958197 16081117 18071297 16177239
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.5618218290 15265979
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 15.5617654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.5619107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 15.5619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.5620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3411462148
MESH:D050171 Dyslipidemias Dietary Fats 3.0418367378
MESH:D004421 Dystonia Phenobarbital 3.491851702
MESH:D004485 Eczema Dexamethasone 3.9312438553
MESH:D004487 Edema Arachidonic Acid 16.449599246 9831321 15177302 11698051 7990266 16716910
MESH:D004487 Edema Dexamethasone 16.4419703484
MESH:D004487 Edema pirinixic acid 16.4412083418
MESH:D004487 Edema Raloxifene 16.4415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.0615322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.0618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 17.6112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.6117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.6115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.6119031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.0416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.0416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 19.3216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 19.3218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Genistein 19.3211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 19.3219155303 17893378 16202921 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 19.3216569247
MESH:D004715 Endometriosis Mifepristone 12.5316134523
MESH:D004715 Endometriosis Progesterone 12.5316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 12.539294722 10568697
MESH:D004802 Eosinophilia Cyclophosphamide 3.6811006010
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.573659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.5820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.076401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.463659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 8.9220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 8.9216530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 8.9215173087 16785472 16337965 16481741 17638652
MESH:D004938 Esophageal Neoplasms Zinc 8.9216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.4316938888 9664655
MESH:D005234 Fatty Liver Amiodarone 40.0214986274
MESH:D005234 Fatty Liver arsenite 40.0218296743
MESH:D005234 Fatty Liver Cyclosporine 40.0219224547
MESH:D005234 Fatty Liver Dietary Fats 40.0217967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 40.0220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.0215345470
MESH:D005234 Fatty Liver pirinixic acid 40.0220131406 19236843
MESH:D005234 Fatty Liver Raloxifene 40.0217473493
MESH:D005234 Fatty Liver Tamoxifen 40.0219224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.0216534752 16002989 16611131 15751030 16513791
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.0216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9111858732
MESH:D005334 Fever Arachidonic Acid 4.1711852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6319069698
MESH:D005355 Fibrosis arsenite 27.5018296743
MESH:D005355 Fibrosis Cyclosporine 27.5012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 27.5018296743
MESH:D005355 Fibrosis Quercetin 27.5019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 27.5020067830
MESH:D005355 Fibrosis Tretinoin 27.5017994277
MESH:D005414 Flatulence orlistat 6.0720002075
MESH:D005756 Gastritis Acetaminophen 9.2816983495
MESH:D005756 Gastritis Zinc 9.2817241300
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.3916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.668708960
MESH:D005909 Glioblastoma Fenretinide 13.8816187019
MESH:D005909 Glioblastoma Genistein 13.8816598420
MESH:D005909 Glioblastoma Quercetin 13.8819804834
MESH:D005909 Glioblastoma Tretinoin 13.8817312396
MESH:D005910 Glioma Fluorouracil 5.3416145905
MESH:D005910 Glioma Quercetin 5.3417643826
MESH:D018316 Gliosarcoma Cyclophosphamide 4.9611389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0310696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.4916376943 15172196 11014644
MESH:D006130 Growth Disorders Zinc 3.5917217573
MESH:D006258 Head and Neck Neoplasms Fluorouracil 6.4918337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.4916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.2320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.2311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 9.239664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 6.7616019553
MESH:D006331 Heart Diseases Raloxifene 6.7611110106
MESH:D006333 Heart Failure pirinixic acid 5.9420558911
MESH:D006333 Heart Failure Zinc 5.9417162251
MESH:D006335 Heart Injuries Zinc 5.2017074742
MESH:D016481 Helicobacter Infections Zinc 4.0217241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.8615720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.7511918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 4.9714986274
MESH:D006527 Hepatolenticular Degeneration Zinc 9.5117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 9.5117063115
MESH:D006529 Hepatomegaly Amiodarone 16.2415265979
MESH:D006529 Hepatomegaly Phenobarbital 16.2416109766
MESH:D006529 Hepatomegaly pirinixic acid 16.2418467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.2412621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.857520565
MESH:D006558 Herpes Genitalis Estradiol 4.4615709030
MESH:D006561 Herpes Simplex Etoposide 4.0110809021
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.3416135485 17606976
MESH:D006689 Hodgkin Disease Etoposide 6.3417606976 18180244 16200630 16135485 15147373
MESH:D019584 Hot Flashes Estradiol 3.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.4815340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.1516870215
MESH:D006930 Hyperalgesia Tretinoin 6.1516870215
MESH:D006937 Hypercholesterolemia Amiodarone 7.519751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 7.5121332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0216778211
MESH:D006943 Hyperglycemia pirinixic acid 7.6320558911
MESH:D006943 Hyperglycemia Quercetin 7.6311834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 7.9821332399
MESH:D006949 Hyperlipidemias orlistat 7.9821332399
MESH:D006965 Hyperplasia Diethylstilbestrol 3.8912960047 14722030
MESH:D006973 Hypertension Cyclosporine 13.7710903974
MESH:D006973 Hypertension Dexamethasone 13.7717042910
MESH:D006973 Hypertension Quercetin 13.7718356687
MESH:D006973 Hypertension Raloxifene 13.7715787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 13.7718850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 9.4416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.4416945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 3.967265320
MESH:D007037 Hypothyroidism Amiodarone 3.9717991464 18020914
MESH:D007154 Immune System Diseases Cyclophosphamide 4.7616076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.8615869954
MESH:D007246 Infertility Diethylstilbestrol 3.8315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9512013081
MESH:D007248 Infertility, Male Cyclophosphamide 5.5916517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5917937319
MESH:D007249 Inflammation Arachidonic Acid 23.0715177302 17371808 9831321
MESH:D007249 Inflammation Dexamethasone 23.078960868 11099482
MESH:D007249 Inflammation Dietary Fats 23.0720412841
MESH:D007249 Inflammation Diethylnitrosamine 23.0718785209
MESH:D007249 Inflammation polyphenols 23.0716366677
MESH:D007249 Inflammation Progesterone 23.0715869954
MESH:D007249 Inflammation Tamoxifen 23.0719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.0712878042 12200463
MESH:D007251 Influenza, Human Quercetin 3.9416624496
MESH:D007333 Insulin Resistance Dietary Fats 14.5811836018 18457598
MESH:D007333 Insulin Resistance Estradiol 14.5816393666 16627594
MESH:D007333 Insulin Resistance orlistat 14.5817201808
MESH:D007333 Insulin Resistance pirinixic acid 14.5816306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2317994277
MESH:D007511 Ischemia Zinc 4.0916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.2716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.2717551590 15992940
MESH:D007627 Keloid Quercetin 4.4117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.8715604871
MESH:D007674 Kidney Diseases Acetaminophen 15.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 15.4118776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 15.4115618244
MESH:D007674 Kidney Diseases Quercetin 15.4116962696
MESH:D007674 Kidney Diseases Zinc 15.4116960431
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 6.0717185156
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 8.5616518626
MESH:D007676 Kidney Failure, Chronic Zinc 8.5616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 23.2116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 23.2112371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 23.2114681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 23.2115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 23.2116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 23.2118625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5217184923
MESH:D007889 Leiomyoma Raloxifene 3.9816973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.8115237267
MESH:D007938 Leukemia therapeutic 17379067
MESH:D007938 Leukemia Cyclophosphamide 12.4910602166
MESH:D007938 Leukemia Genistein 12.4917468513 18980019
MESH:D007938 Leukemia Quercetin 12.4917468513
MESH:D007938 Leukemia Tretinoin 12.4917143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 6.0918587576 17008537 18172266 17658394 17296974 17802794
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 6.0918172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.6710373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.7716766008 17294898 16140955 9834237 15748426 16823087 19029980 17506722 17301526 16891316 16935935 17649720 16331271 17361223 19225113 12679006 17368321 16788101 17339181 17712046 19642359 19075265 19035177 17107899 17217047
MESH:D007970 Leukopenia Cyclophosphamide 4.4110052129 11830472
MESH:D007972 Leukoplakia, Oral Fenretinide 5.4816707609
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.909224671
MESH:D008064 Lipidoses Amiodarone 6.5515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.5515342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 17.2518296743
MESH:D008103 Liver Cirrhosis Dietary Fats 17.2518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 17.2520032147 19638242 18665156 18407596 18522880
MESH:D008103 Liver Cirrhosis orlistat 17.2517404856
MESH:D008103 Liver Cirrhosis Phenobarbital 17.2521047994
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 11.5616718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 11.5614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 11.5617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 11.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 11.5612741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 11.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 11.5612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 11.5616248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 7.9019014921 16610002 12969438 11587558 19460945 12587719 19784758 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 7.9017034775
MESH:D008107 Liver Diseases Phenobarbital 7.9019363144
MESH:D008107 Liver Diseases polyphenols 7.9016698588
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7516871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.872125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 32.8720195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 32.8719812893 19090486 20137499 20501860 12771043 21167192 20452335 20583210 19254457 20118626 12112319 16942905 20101389 9163691 21278145 18977376 19690152 18648771 19638242 15885732 19499222 21071580 15175105 19256749 21047994 2422723 18644402 19642983 10737359 19833225 20405173 19551842 20492335 19996281 18754104 18978307 19426721 2862719 19850985 19255062 19294768 19073162 20434301 19427195
MESH:D008113 Liver Neoplasms Diethylstilbestrol 32.8716712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 32.8718383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Mitomycin 32.8715113037
MESH:D008113 Liver Neoplasms Phenobarbital 32.8719812893 8742319 15975961 21047994 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 32.8716377806 15890375 20007298
MESH:D008113 Liver Neoplasms Quercetin 32.8718980244
MESH:D008113 Liver Neoplasms Tamoxifen 32.8716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.8716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.778603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.7718775883 17854601 18544905 18282651 18079962 18308698 19009564 17174075 19539802 9362446 16267830 19126423 17942915 19004024 18093689 16842330 3124819 21159647 18253720 2563599 19519916 18164116
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.7717172636 1399818 2563599 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 14.7719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.1517391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 6.3012587719
MESH:D008171 Lung Diseases Ozone 6.3019066396 8266340
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.9118516814
MESH:D055370 Lung Injury Ozone 3.3120417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 18.2614755239
MESH:D008175 Lung Neoplasms arsenite 18.2616809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.2617053015 20135361 20064080 6695378 18816296 18520028 20869020 18569708 20464547
MESH:D008175 Lung Neoplasms bexarotene 18.2617849452
MESH:D008175 Lung Neoplasms Dexamethasone 18.2615824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.2620512841 21163286 6695378 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 18.2615246190
MESH:D008175 Lung Neoplasms Ozone 18.268597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 18.2616280456
MESH:D008175 Lung Neoplasms Tamoxifen 18.2618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.2611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.2315086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.5915166399
MESH:D008207 Lymphatic Metastasis orlistat 5.3520805790 18770866
MESH:D008223 Lymphoma Cyclophosphamide 10.3912854902
MESH:D008223 Lymphoma Diethylstilbestrol 10.3915700306
MESH:D008223 Lymphoma Etoposide 10.3912854902 12556972
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.0816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7111911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6011161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 4.9516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2119428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 22.7715591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.7711807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 22.7710697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 22.7712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.7711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.7714580682 19196722 11731420 16827153 19196723
MESH:D008325 Mammary Neoplasms, Experimental Zinc 22.7712773700
MESH:D020149 Manganese Poisoning Estradiol 10.7619453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.7619453300
MESH:D008527 Medulloblastoma Tretinoin 2.5417453147
MESH:D008545 Melanoma Fenretinide 6.3216270382
MESH:D008545 Melanoma orlistat 6.3218770866 20805790
MESH:D008545 Melanoma Tamoxifen 6.3212393984 19393235
MESH:D008545 Melanoma Tretinoin 6.3216752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.0319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.0316388313
MESH:D008591 Meningomyelocele Tretinoin 3.8816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2216801185
MESH:D008679 Metaplasia Ozone 4.5410496685
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 4.9915863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 11.9516381670
MESH:D009062 Mouth Neoplasms Fenretinide 11.9516274795
MESH:D009062 Mouth Neoplasms Fluorouracil 11.9518986760 16757204
MESH:D009101 Multiple Myeloma Dexamethasone 6.2015867202 15744524 16118317
MESH:D009101 Multiple Myeloma Raloxifene 6.2016497877
MESH:D009135 Muscular Diseases orlistat 8.9418430571
MESH:D009135 Muscular Diseases pirinixic acid 8.9416239165
MESH:D009164 Mycobacterium Infections orlistat 4.9321442799
MESH:D009181 Mycoses Amiodarone 4.3312754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.409809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4017596541
MESH:D009203 Myocardial Infarction Genistein 7.9517141266
MESH:D009203 Myocardial Infarction pirinixic acid 7.9519151258
MESH:D009203 Myocardial Infarction Quercetin 7.9519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.5712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 16.7416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 16.7417141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 16.7416411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 16.7419207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9217484760
MESH:D009232 Myxoma Raloxifene 4.9916343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 4.889029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 4.8819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 30.8411141357
MESH:D009369 Neoplasms Cyclophosphamide 30.8418854779
MESH:D009369 Neoplasms Diethylstilbestrol 30.8415313581
MESH:D009369 Neoplasms Fenretinide 30.8415958647 17353921
MESH:D009369 Neoplasms Fluorouracil 30.8416928823 18600527 18239605
MESH:D009369 Neoplasms Mitoxantrone 30.8416640825
MESH:D009369 Neoplasms orlistat 30.8418710210
MESH:D009369 Neoplasms pirinixic acid 30.8417405874
MESH:D009369 Neoplasms Quercetin 30.8415185748
MESH:D009369 Neoplasms Tretinoin 30.8416946489 16594593
MESH:D009374 Neoplasms, Experimental orlistat 4.5219381703
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.0519196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.0519200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 13.9615738583
MESH:D009389 Neovascularization, Pathologic Estradiol 13.9617289903
MESH:D009389 Neovascularization, Pathologic orlistat 13.9617012255
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.8717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8118481113 19348381
MESH:D009410 Nerve Degeneration therapeutic 17005863
MESH:D009421 Nervous System Malformations Diethylstilbestrol 25.1611399458
MESH:D009421 Nervous System Malformations Estradiol 25.1616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 25.1616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 25.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 25.169125849
MESH:D009436 Neural Tube Defects Tretinoin 2.689142499
MESH:D009447 Neuroblastoma Cyclophosphamide 6.388761367 15176712 16115947
MESH:D009447 Neuroblastoma Topotecan 6.3815176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.6620387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.338761367 12837982
MESH:D020078 Neurogenic Inflammation Quercetin 3.8517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5520387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.1216303764
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.0516436463
MESH:D009503 Neutropenia Cyclophosphamide 3.828291058
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.0617404856
MESH:D009765 Obesity Dietary Fats 6.5520132043 21332399 11836018 17217161 18457598 19632207 20518802 18674790 16723640
MESH:D009765 Obesity orlistat 6.5520599501 20518802 19046740 20065556 16938137 18773755 19207292 21438711 20002075 19461584 20540997 21442799
MESH:D009765 Obesity pirinixic acid 6.5520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9512819281 16049721
MESH:D009845 Oligospermia Cyclophosphamide 4.1616517039
MESH:D010018 Osteomalacia Phenobarbital 3.8117016548
MESH:D010024 Osteoporosis Genistein 6.1319401787
MESH:D010024 Osteoporosis Raloxifene 6.1317882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Genistein 13.9316169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 13.9319495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 13.9315758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 19.6919401270
MESH:D010051 Ovarian Neoplasms Fenretinide 19.6916133793
MESH:D010051 Ovarian Neoplasms Genistein 19.6919005980
MESH:D010051 Ovarian Neoplasms Mifepristone 19.6916525653
MESH:D010051 Ovarian Neoplasms Progesterone 19.6917393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 19.6919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 19.6916936753
MESH:D010146 Pain Acetaminophen 12.4716870215
MESH:D010146 Pain AM 251 12.4718987195
MESH:D010146 Pain Cyclophosphamide 12.4712161096 18093676
MESH:D010146 Pain Tretinoin 12.4716870215
MESH:D010190 Pancreatic Neoplasms AM 251 37.9916500647
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 37.9911332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 37.9916540662
MESH:D010190 Pancreatic Neoplasms Etoposide 37.9919003803
MESH:D010190 Pancreatic Neoplasms Fenretinide 37.9915580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 37.9916929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms gemcitabine 37.9911504793 16929163 17440100 18992248 18383843
MESH:D010190 Pancreatic Neoplasms Mitomycin 37.9915113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 37.9916965848
MESH:D010190 Pancreatic Neoplasms Quercetin 37.9916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 37.9915976015
MESH:D010195 Pancreatitis orlistat 4.3416938137 20065556
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.1711578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.5512065085
MESH:D010300 Parkinson Disease therapeutic 17005863
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6812520081
MESH:D010538 Peritonitis Ozone 3.5916369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1315687265 16977796
MESH:D011014 Pneumonia Ozone 3.8418381685 18929643 18007984
MESH:D011085 Polycystic Ovary Syndrome orlistat 4.7917201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0318163543
MESH:D011230 Precancerous Conditions Cyclosporine 18.0212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.022563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.022563599
MESH:D011230 Precancerous Conditions Quercetin 18.0219056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 6.7021297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 6.7021297632
MESH:D011225 Pre-Eclampsia Zinc 3.7417114810
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 7.7317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7311896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 4.5417292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 4.5417136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 4.5415846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 4.5416740699
MESH:D011471 Prostatic Neoplasms Etoposide 4.5417172428
MESH:D011471 Prostatic Neoplasms Fenretinide 4.5417024972
MESH:D011471 Prostatic Neoplasms Fluorouracil 4.5419082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 4.5416925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Quercetin 4.5414715546 17292933
MESH:D011471 Prostatic Neoplasms Raloxifene 4.5415731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 4.5415067354
MESH:D011471 Prostatic Neoplasms Zinc 4.5416700911 16517595 16606632 12429649
MESH:D011507 Proteinuria Tretinoin 3.0916636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.7615861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 3.9312752131
MESH:D011565 Psoriasis Cyclosporine 2.0116882103
MESH:D011625 Pterygium Tretinoin 4.2416723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.1611597910 12832656 12490602
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.1616636934
MESH:D011693 Purpura Raloxifene 4.9915770314
MESH:D012004 Rectal Neoplasms Fluorouracil 3.5415538739 18286688 18722050 16160472
MESH:D012035 Refsum Disease orlistat 5.5120871815
MESH:D015427 Reperfusion Injury pirinixic acid 2.0919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.5118379247 11700416
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3118990726
MESH:D012162 Retinal Degeneration Fenretinide 7.9816303925
MESH:D012162 Retinal Degeneration Zinc 7.9816584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.5916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6318045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.1814601052
MESH:D012554 Schistosomiasis japonica Quercetin 4.9816862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3116636934
MESH:D012640 Seizures 2,4-dinitrotoluene 4.6418551238
MESH:D012640 Seizures Phenobarbital 4.644039156 16876388 3137016 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.266407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.5318724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.8319755658 10029692
MESH:D012878 Skin Neoplasms Fenretinide 14.8316467112
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.8312065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.8316192470
MESH:D012878 Skin Neoplasms Tretinoin 14.8316467112
MESH:D013088 Spermatocele Diethylstilbestrol 16.8516002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 16.8516709447
MESH:D013088 Spermatocele Tamoxifen 16.8516709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 4.9616517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.0215862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0219457130
MESH:D013272 Stomach Diseases Dexamethasone 3.7715472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 5.602093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 5.6018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 5.6016951190 17172411 18567086 19084572 19015929 17522103 15786421 16424979 17498489 18396642
MESH:D013274 Stomach Neoplasms orlistat 5.6019381703
MESH:D013274 Stomach Neoplasms Tretinoin 5.6017261132
MESH:D013276 Stomach Ulcer Amiodarone 9.4518087811
MESH:D013276 Stomach Ulcer Dexamethasone 9.4515138204
MESH:D013276 Stomach Ulcer olive oil 9.4512498302 16252198
MESH:D020521 Stroke Raloxifene 3.3816837676
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5012837982
MESH:D013610 Tachycardia Amiodarone 3.7611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.6619225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.6817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.6815669648
MESH:D013959 Thyroid Diseases Amiodarone 10.1619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.1612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 9.497505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 9.491399818
MESH:D013964 Thyroid Neoplasms Tretinoin 9.4916026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.3219584973 18020914
MESH:D013978 Tibial Fractures Estradiol 11.8219048282
MESH:D013978 Tibial Fractures Raloxifene 11.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 13.8016280240
MESH:D014062 Tongue Neoplasms Tretinoin 13.8016051514
MESH:D014062 Tongue Neoplasms Zinc 13.8016543248
MESH:D016171 Torsades de Pointes Amiodarone 3.6411989578 17467628
MESH:D014376 Tuberculosis Tretinoin 2.8616040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 24.0916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 24.0917053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 24.0914692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 24.0917306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 24.0916720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 24.0916720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 24.0917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 24.0916712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.7610091137
MESH:D014581 Urticaria Acetaminophen 2.4710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 18.6916175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 18.6916154183
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 18.6916803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 18.6916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.7215809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.7214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.0416752155
MESH:D014605 Uveitis Cyclosporine 9.881336536
MESH:D014605 Uveitis Dexamethasone 9.881336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.8916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0414671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.5316761959
MESH:D014846 Vulvar Neoplasms Raloxifene 4.9916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6815886252
MESH:D015430 Weight Gain Dietary Fats 3.2716723640
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
MESH:D014985 Xerophthalmia Cyclosporine 3.8717120751
Pathway ID Pathway Name
KEGG:04150 mTOR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134977994
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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