AutismKB 2.0

Annotation Detail for GNL3L


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Basic Information Top
Gene Symbol:GNL3L ( FLJ10613 )
Gene Full Name: guanine nucleotide binding protein-like 3 (nucleolar)-like
Band: Xp11.22
Quick LinksEntrez ID:54552; OMIM: NA; Uniprot ID:GNL3L_HUMAN; ENSEMBL ID: ENSG00000130119; HGNC ID: 25553
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GNL3L mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GNL3L mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNL3L mRNAdecreases expression 20018196
D004958 Estradiol Estradiol results in decreased expression of GNL3L mRNAdecreases expression 20106945
C004648 testosterone enanthate testosterone enanthate affects the expression of GNL3L mRNAaffects expression 17440010
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 4.497525203
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D001943 Breast Neoplasms Estradiol 2.1116675129 12948864 17018787 17289903 18497071 17261762 19861407 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0916705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0916924424
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.8114694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.4418566989
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.4915095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.3818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 4.3821346803
MESH:D016889 Endometrial Neoplasms Estradiol 3.2018566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.3617440010
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D007333 Insulin Resistance Estradiol 3.1816627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7615618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3916705839
MESH:D007680 Kidney Neoplasms Estradiol 8.3915610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7711408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.3116049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.3114694615
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
Pathway ID Pathway Name
KEGG:03008 Ribosome biogenesis in eukaryotes
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018