AutismKB 2.0

Annotation Detail for ING3


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Basic Information Top
Gene Symbol:ING3 ( Eaf4,FLJ20089,ING2,MEAF4,p47ING3 )
Gene Full Name: inhibitor of growth family, member 3
Band: 7q31.31
Quick LinksEntrez ID:54556; OMIM: 607493; Uniprot ID:ING3_HUMAN; ENSEMBL ID: ENSG00000071243; HGNC ID: 14587
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ING3 mRNAaffects expression 17562736
D000965 Antimony Antimony results in increased expression of ING3 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of ING3 mRNAincreases expression 17547211
D001151 Arsenic Arsenic affects the expression of ING3 mRNAaffects expression 18414638
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ING3 mRNAincreases expression 20504355
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ING3 mRNAdecreases expression 20018196
19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ING3 mRNAdecreases expression 15336504
C071834 glycidamide glycidamide results in decreased expression of ING3 mRNAdecreases expression 17822822
C051890 irinotecan irinotecan analog results in decreased expression of ING3 mRNAdecreases expression 18927307
D019800 Phenol Phenol results in increased expression of ING3 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ING3 mRNAaffects binding|decreases expression|increases activity 19710929
C025643 vinclozolin vinclozolin affects the expression of ING3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8916251483 12569548 16835338 18414634
MESH:D050197 Atherosclerosis Arsenic 3.3112928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001859 Bone Neoplasms Phenol 5.3210556009
MESH:D001913 Bowen's Disease Phenol 5.9319293009
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001991 Bronchitis Antimony 6.318768112
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6515504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.063084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.0617306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.8115504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8120419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D002311 Cardiomyopathy, Dilated Antimony 3.9510334427
MESH:D002318 Cardiovascular Diseases Arsenic 3.5217938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4116973168 18022660
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8020889678
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003110 Colonic Neoplasms irinotecan 2.6117287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617159606 18509181 18259882 16303861 16391804 15273666 17454858
MESH:D003456 Cryptorchidism vinclozolin 4.4714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D004283 Dog Diseases Antimony 5.8112019027
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6118713872 18071297 12153990 16109766 17562736 17522070 19370779 16081117 16485898 11287661 12392966 19085960 19923254 14986274 11529661 17906064 16393943 19739265 19164858 16227642 12540782 11421492 11739529 14725611 14550746 19416960 11743745 12705907 12594235 11834606 19420014 10915739 10663392 11461765 15619225 15968718 2444490 12958197 10774834 16781746 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005234 Fatty Liver pirinixic acid 2.8720131406 19236843
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0916973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4716417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 2.9016076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007248 Infertility, Male vinclozolin 3.1116467254
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007642 Keratosis Arsenic 5.1416930632 12749816
MESH:D055623 Keratosis, Actinic Phenol 6.6219293009
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D007896 Leishmaniasis Antimony 4.9112019027 15220340 21182181 10953559 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.7611475954 19141829 8889330
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.649643325 11370249 10651420 10881086 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 9.027854095 7554475 11105143 7875148 8142506 20495762 1899875
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 9.0212707265
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 8.499834237
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.4917339181
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8916417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.1516611625 19460945 16610002 19014921 12587719 12969438 11587558 19784758
MESH:D008107 Liver Diseases Arsenic 4.1511134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 7.6616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 7.6620007298 16377806 15890375
MESH:D008175 Lung Neoplasms Arsenic 2.5719168569 17976673 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5717053015 20464547 18520028 20135361 20869020 18569708 6695378 18816296 20064080
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D052016 Mucositis irinotecan 5.1617159606
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0715371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009362 Neoplasm Metastasis irinotecan 3.2118259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009436 Neural Tube Defects Arsenic 3.5216620997
MESH:D009447 Neuroblastoma irinotecan 3.538761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.888761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.7717306315
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Phenol 7.3717610455
MESH:D010392 Pemphigus Phenol 6.6216522979 17163923
MESH:D010409 Penile Diseases Antimony 5.859643325
MESH:D010493 Pericarditis Antimony 6.2720465667
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1416905509 15371236 6392382
MESH:D010864 Pilonidal Sinus Phenol 6.6219655223 15622588
MESH:D011041 Poisoning Phenol 4.838825745
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0518220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0918220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.2716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2717292933
MESH:D011472 Prostatitis vinclozolin 5.0918629315
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012871 Skin Diseases Arsenic 2.7717050553 19834688 16702368 17548696 18709164 15952646 17938729 17453740 6392382 16353154 16759981
MESH:D012878 Skin Neoplasms Arsenic 9.8117976673 16251483 17029826 15504454 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8119755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.818532709
MESH:D013088 Spermatocele Phenol 5.8118646496
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.5820155912 2093021
MESH:D013274 Stomach Neoplasms irinotecan 2.5815723263
MESH:D014277 Trigeminal Neuralgia Phenol 6.6210223447 16527771
MESH:D014352 Trypanosomiasis Antimony 6.1015220340
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.3018640142 11144890 15987713 19322015 19429237 17976673 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3017053015
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D014860 Warts Phenol 6.2719122958
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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