AutismKB 2.0

Annotation Detail for POU4F2


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Basic Information Top
Gene Symbol:POU4F2 ( BRN3.2,BRN3B,Brn-3b )
Gene Full Name: POU class 4 homeobox 2
Band: 4q31.22
Quick LinksEntrez ID:5458; OMIM: 113725; Uniprot ID:PO4F2_HUMAN; ENSEMBL ID: ENSG00000151615; HGNC ID: 9219
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200101Direct p53 effectors
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POU4F2 mRNAaffects expression 16483693
C004742 daidzein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNAaffects cotreatment|decreases expression 16963248
D019833 Genistein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNAaffects cotreatment|decreases expression 16963248
C086566 glycitein [Genistein co-treated with daidzein co-treated with glycitein] results in decreased expression of POU4F2 mRNAaffects cotreatment|decreases expression 16963248
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POU4F2 mRNAaffects binding|increases activity|increases expression 19710929
D014212 Tretinoin Tretinoin results in decreased expression of POU4F2 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma daidzein 5.1711473722
MESH:D000230 Adenocarcinoma Genistein 5.1711473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000505 Alopecia Tretinoin 3.8715955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3216292516
MESH:D001249 Asthma Tretinoin 2.4216456186
MESH:D001471 Barrett Esophagus Tretinoin 4.7816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.0819483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.0816197459 16206674
MESH:D001943 Breast Neoplasms Genistein 2.2617200150 16541309 16873071
MESH:D001943 Breast Neoplasms Tretinoin 2.2616443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.0516813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6816168501
MESH:D006528 Carcinoma, Hepatocellular Genistein 3.2616924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.261917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3616051514 16096774
MESH:D002318 Cardiovascular Diseases daidzein 8.5016332659
MESH:D002318 Cardiovascular Diseases Genistein 8.5016332659
MESH:D002386 Cataract Tretinoin 3.2617460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.0516129372
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D002822 Choriocarcinoma Tretinoin 5.6816461808
MESH:D002972 Cleft Palate Tretinoin 2.789407595
MESH:D003092 Colitis Tretinoin 4.1217035595
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 14991402 16925845 9224671 10589399 9142499 17551590 9125849 9664655 9211117
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 5.1916647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 5.1916647724
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004489 Edema, Cardiac Tretinoin 4.9918230668
MESH:D004714 Endometrial Hyperplasia Genistein 5.0516402032
MESH:D016889 Endometrial Neoplasms daidzein 13.7911473722
MESH:D016889 Endometrial Neoplasms Genistein 13.7911473722
MESH:D016889 Endometrial Neoplasms Tretinoin 13.7916569247
MESH:D007172 Erectile Dysfunction daidzein 5.4014972507
MESH:D005124 Eye Abnormalities Tretinoin 3.8116938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005355 Fibrosis Tretinoin 3.9317994277
MESH:D005909 Glioblastoma Genistein 7.8516598420
MESH:D005909 Glioblastoma Tretinoin 7.8517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.049664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 16221962 19176532 18467677
MESH:D006930 Hyperalgesia Tretinoin 3.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9916778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006973 Hypertension daidzein 3.7617169123
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007410 Intestinal Diseases Tretinoin 4.1817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2317551590 15992940
MESH:D007938 Leukemia Genistein 6.8718980019 17468513
MESH:D007938 Leukemia Tretinoin 6.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1217596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3419225113 17339181 16935935 17294898 16331271 16891316 19029980 19642359 16766008 19075265 12679006 9834237 16140955 17649720 17301526 17107899 15748426 17361223 17506722 17712046 16788101 17368321 16823087 17217047 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.539224671
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6615474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6618397230 16248980
MESH:D008113 Liver Neoplasms pirinixic acid 1.9116377806 20007298 15890375
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1214578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.8817453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.8416940565
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2417596541
MESH:D009203 Myocardial Infarction Genistein 6.0417141266
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.2016411023
MESH:D009369 Neoplasms pirinixic acid 5.3617405874
MESH:D009369 Neoplasms Tretinoin 5.3616594593 16946489
MESH:D009421 Nervous System Malformations Genistein 11.1116427766
MESH:D009421 Nervous System Malformations Tretinoin 11.119125849
MESH:D009436 Neural Tube Defects Tretinoin 3.249142499
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010024 Osteoporosis Genistein 3.4319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.4416169203
MESH:D010051 Ovarian Neoplasms Genistein 5.2119005980
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2116936753
MESH:D010146 Pain Tretinoin 3.1616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5515976015
MESH:D011471 Prostatic Neoplasms Genistein 3.4115378649 16925846 15256057
MESH:D011507 Proteinuria Tretinoin 3.9516636307
MESH:D011625 Pterygium Tretinoin 5.2616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4516283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7316467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0916051514
MESH:D014376 Tuberculosis Tretinoin 3.4116040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9816129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.1316752155
MESH:D014820 Vitiligo Tretinoin 4.4416761959
MESH:D009396 Wilms Tumor Tretinoin 4.2516287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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