AutismKB 2.0

Annotation Detail for GNB1L


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Basic Information Top
Gene Symbol:GNB1L ( DGCRK3,GY2,KIAA1645,WDR14,WDVCF )
Gene Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 1-like
Band: 22q11.21
Quick LinksEntrez ID:54584; OMIM: 610778; Uniprot ID:GNB1L_HUMAN; ENSEMBL ID: ENSG00000185838; HGNC ID: 4397
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GNB1L mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GNB1L mRNAdecreases expression 20064835
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0720464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.443712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.446695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.8419183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9820146248 17474063
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.787296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1520419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5511906362 8156756 14531868 18759878 8970840 2524372 11298694 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.103621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0618289764 8291058 16192314 9328219 9653073 9022650 1440618 11289319 6482804 6679447 18692083 18648102 7440962
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.683581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8720471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.099022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.806587162 598648 1399818 3712494
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.576695378 17053015 20135361 20064080 18816296 18520028 20464547 20869020 18569708
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5716381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3611141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9017292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5510029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.263712494 6582329 7505956 6587162 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.478074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4717053015
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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