AutismKB 2.0

Annotation Detail for POU4F3


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Basic Information Top
Gene Symbol:POU4F3 ( BRN3C,DFNA15,MGC138412 )
Gene Full Name: POU class 4 homeobox 3
Band: 5q32
Quick LinksEntrez ID:5459; OMIM: 602460; Uniprot ID:PO4F3_HUMAN; ENSEMBL ID: ENSG00000091010; HGNC ID: 9220
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Deafness, autosomal dominant 15
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of POU4F3 mRNAaffects cotreatment|affects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of POU4F3 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000169 Acrodermatitis Zinc 6.2916889938 17190629 17202136
MESH:D000544 Alzheimer Disease Zinc 2.8316580781 17119284 16410023 16325427
MESH:D000755 Anemia, Sickle Cell Zinc 5.5816916123
MESH:D001249 Asthma Zinc 3.0617085522
MESH:D001930 Brain Injuries Zinc 5.4517109824
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.4918922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.4916543248
MESH:D002318 Cardiovascular Diseases Zinc 3.9816936243
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
OMIM:602459 DEAFNESS, AUTOSOMAL DOMINANT 15 marker/mechanism
MESH:D003920 Diabetes Mellitus Zinc 4.6716479319
MESH:D004487 Edema Tetradecanoylphorbol Acetate 4.1515177302 7812673 9599246 8113982 11698051 8273558 16716910
MESH:D004938 Esophageal Neoplasms Zinc 2.9516543248
MESH:D005756 Gastritis Zinc 5.8717241300
MESH:D006130 Growth Disorders Zinc 4.2517217573
MESH:D006333 Heart Failure Zinc 3.8817162251
MESH:D006335 Heart Injuries Zinc 6.8417074742
MESH:D016481 Helicobacter Infections Zinc 5.1417241300
MESH:D006527 Hepatolenticular Degeneration Zinc 5.4517276780
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.307562506 8273558 11698051 15177302 7812673
MESH:D007511 Ischemia Zinc 5.3916584753
MESH:D007674 Kidney Diseases Zinc 3.5616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.9716518626
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.4811807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 7.498985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 7.4912773700
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.2615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 5.0518922899 8330346 18404319 12065085
MESH:D011225 Pre-Eclampsia Zinc 4.5617114810
MESH:D011471 Prostatic Neoplasms Zinc 3.7516517595 16700911 12429649 16606632
MESH:D012162 Retinal Degeneration Zinc 4.4916584753
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.468985016 12065085 8330346 11807781 18404319
MESH:D014062 Tongue Neoplasms Zinc 4.9016543248
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018