AutismKB 2.0

Annotation Detail for ATRX


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Basic Information Top
Gene Symbol:ATRX ( ATR2,MGC2094,MRXHF1,RAD54,RAD54L,SFM1,SHS,XH2,XNP,ZNF-HX )
Gene Full Name: alpha thalassemia/mental retardation syndrome X-linked
Band: Xq21.1
Quick LinksEntrez ID:546; OMIM: 300032; Uniprot ID:ATRX_HUMAN; ENSEMBL ID: ENSG00000085224; HGNC ID: 886
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2001Mental retardation
2204Hemolytic anemia
No data
No data
Desease Name
Alpha-thalassemia myelodysplasia syndrome, somatic
Alpha-thalassemia/mental retardation syndrome
Mental retardation-hypotonic facies syndrome, X-linked
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATRX mRNAaffects expression 21346803
D006710 Homocysteine Homocysteine results in decreased expression of ATRX mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ATRX mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in increased expression of ATRX mRNAincreases expression 12420312
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATRX mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ATRX mRNAaffects expression 17484886
D003010 Clorgyline Clorgyline results in increased expression of ATRX mRNAincreases expression 19691856
D004958 Estradiol Estradiol results in decreased expression of ATRX mRNAdecreases expression 20068009
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ATRX geneincreases mutagenesis 16495775
C051890 irinotecan irinotecan analog results in decreased expression of ATRX mRNAdecreases expression 18927307
D016685 Mitomycin ATRX protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of ATRX mRNAdecreases expression 17616710
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of ATRX mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of ATRX mRNAdecreases expression 19244175
C004648 testosterone enanthate testosterone enanthate results in increased expression of ATRX mRNAincreases expression 17440010
C025643 vinclozolin vinclozolin affects the expression of ATRX mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of ATRX mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of ATRX mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000236 Adenoma Ethylnitrosourea 3.736695378
OMIM:300448 ALPHA-THALASSEMIA MYELODYSPLASIA SYNDROME marker/mechanism
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:C538258 ATR-X syndrome marker/mechanism
MESH:D001321 Autistic Disorder Homocysteine 3.0420468076 16297937
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9114991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3215144691 16357521 16651633 16436596 18412241
MESH:D001943 Breast Neoplasms Estradiol 2.1516675129 17289903 14630087 17261762 17018787 19861407 18497071 12948864
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.0815721981 15700767 16192424 15673190 16050911 16227642 3786805 18705752 16124888 16011737 10355542 16097048
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.0816050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.5916705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5916924424
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.236135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.2320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.2318566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 16.2316003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.0517160924
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6520423518
MESH:D003110 Colonic Neoplasms irinotecan 2.6017287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3618259882 16303861 17159606 17454858 16391804 18509181 15273666
MESH:D003324 Coronary Artery Disease Homocysteine 3.7616379339
MESH:D019465 Craniofacial Abnormalities marker/mechanism 19291773
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9119769572
MESH:D003456 Cryptorchidism marker/mechanism 19291773
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3117522070 7440962 21278145 11566570 6884620 15968718 4309450 16227642 10092053 9327722 15027814 19085960 7179309 16177239 10915739 3786805 2869522 15998439 6623471 3732212 7120509 19336974
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3115131321
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.0518357618
MESH:D016889 Endometrial Neoplasms Estradiol 3.0018566989 19148513 11473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D017889 Exfoliation Syndrome Homocysteine 5.7516504073
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2015959796 12631006 17595544 12795759 61145 19224547 16239168 16045604
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5018705752
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005901 Glaucoma Homocysteine 5.3216504073
MESH:D005909 Glioblastoma Ethylnitrosourea 3.8516436596
MESH:D005910 Glioma Ethylnitrosourea 3.5016651633 16357521 18412241
MESH:D006130 Growth Disorders marker/mechanism 19291773
MESH:D006330 Heart Defects, Congenital Homocysteine 7.2319638421
MESH:D006330 Heart Defects, Congenital Vitamin E 7.2316080930
MESH:D006333 Heart Failure Selenium 3.0917162251
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319900420 19110552
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D019584 Hot Flashes Estradiol 10.2617088409
MESH:D019584 Hot Flashes Vitamin E 10.2614716179
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.7317369066 18234410 17292331
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007248 Infertility, Male vinclozolin 3.0616467254
MESH:D007251 Influenza, Human Selenium 11.1716624496
MESH:D007251 Influenza, Human Vitamin E 11.1716624496
MESH:D007333 Insulin Resistance Estradiol 2.9816627594 16393666
MESH:D007674 Kidney Diseases Estradiol 6.1615618244
MESH:D007674 Kidney Diseases Vitamin E 6.1612488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9116518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6716705839
MESH:D007680 Kidney Neoplasms Estradiol 12.6715610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 12.6717379185
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8216943688 16239168 11903743 17334410 16221502 11408273 17174718 21278145 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5417525996 18251166 16248980 12666154 18156304 17823541 12632514 14512876 18429990 15370692 16027843 16015684 18418968 12445418 17631135 17714472 15876570 18054572 18187930 15818738 17640975 17557913 15362042 18412020 12445421 12389079 13678700 17698563 15338365 15925388 10355542 12898905 18210741 18395914 18339082 18006644 17761835 14620537 17708605 14716496 12667390 12546737 18205269 18376398 17721639 18472094 15673190 17900296 12632512 14716833 15730626 20821823 16192424 11481614 18279442 14748882 17805973 15052691 12609069 18317297 12649538 17481882 18166357 16033810 15057751 17922224 12741479 16097048 16116963 12586293 18420326 17869086 15123356 12958196 15893842 15650968 18472332 17766677 18705752 17976157 18481824 18395095 15996030 16136751 16638106 16011737 17944888 17565644 14724832 15931870 18277467 18263696 15959796
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5416169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0915720792 16964402 16246199 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.657678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.6519294768
MESH:D008113 Liver Neoplasms Mitomycin 7.6515113037
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.972876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9715583823 12014681
MESH:D008171 Lung Diseases Vitamin E 3.1916863852
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.826695378 17703301 16271038 16019985
MESH:D008175 Lung Neoplasms Vitamin E 2.8211062179
MESH:D008223 Lymphoma Ethylnitrosourea 3.9615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.0915375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1811408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.1818041768 10838139 10767621
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1815318939
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008579 Meningioma Ethylnitrosourea 6.0517943659
MESH:D008591 Meningomyelocele Homocysteine 5.5816602021
MESH:C537457 Mental retardation-hypotonic facies syndrome, x-linked, 1 marker/mechanism
MESH:D038901 Mental Retardation, X-Linked marker/mechanism 19291773
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D052016 Mucositis irinotecan 5.0617159606
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 19157545
MESH:D009203 Myocardial Infarction Homocysteine 3.7217412321
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3016810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9118551238 7678174
MESH:D009362 Neoplasm Metastasis irinotecan 3.1818259882
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.4416707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009421 Nervous System Malformations Estradiol 3.6916427766 11399458
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.4716003739 16651423 17160924
MESH:D009447 Neuroblastoma irinotecan 3.498761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.788761367
MESH:D018358 Neuroendocrine Tumors marker/mechanism 21252315
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.4616049721
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.0517160924
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010190 Pancreatic Neoplasms marker/mechanism 21252315
MESH:D010190 Pancreatic Neoplasms Mitomycin 3.4615113037
MESH:D010300 Parkinson Disease Homocysteine 3.5816275827
MESH:D010409 Penile Diseases marker/mechanism 19291773
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Clorgyline 2.7019691856
MESH:D011471 Prostatic Neoplasms Estradiol 2.7016740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7015084515
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D012559 Schizophrenia Homocysteine 3.1116641680
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5518551238
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.9915864552
MESH:D013896 Thoracic Diseases marker/mechanism 19291773
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2115790496
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25179
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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