AutismKB 2.0

Annotation Detail for PARP14


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Basic Information Top
Gene Symbol:PARP14 ( BAL2,KIAA1268,pART8 )
Gene Full Name: poly (ADP-ribose) polymerase family, member 14
Band: 3q21.1
Quick LinksEntrez ID:54625; OMIM: 610028; Uniprot ID:PAR14_HUMAN; ENSEMBL ID: ENSG00000173193; HGNC ID: 29232
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PARP14 mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PARP14 mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in increased expression of PARP14 mRNAincreases expression 17039268
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PARP14 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in decreased expression of PARP14 mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PARP14 mRNAincreases expression 20106945
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PARP14 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6611752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.668875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5920127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.5917638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000740 Anemia Fluorouracil 9.5817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.5811748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001321 Autistic Disorder Valproic Acid 1.9918940202 18316065 18775368 17688650 18396377 18558336 16609825 17507914 15238991 20603192 17157402 18985861 19232924 19460635 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5715746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.578888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8320146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 1.8319217205 16110121 18608205 15136595 16557594 18357371 16595493
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 8.9417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9416835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1116799960 17088986 18930000 16332177 17971768 17045692
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8616757204 17066447 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18670907 18850075
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 15340226 8697196 12621046 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717287894 15001691 16340194 17725105 17016597 16510598 17018589 18772588 17169374 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017016601 18448328 17401013 16524972 17094418 16391804 17454858 16282729 18288408 18802399 18509181 17695437 17255274 16331619 18949393 20501625 18383874 15148649 14970324 16303861 15289873 17594712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5416575769 17688650 8888407
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.363922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6816530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6815173087 16481741 16337965 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver pirinixic acid 8.6819236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.6819224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4618558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5615102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4819772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4918606429 8697196 16354765 15340226 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5416985049
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4221137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 11.4215113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.4216377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5218816296 20135361 20464547 20064080 18569708 17053015 18520028 20869020 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 3.5215246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.2416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.2418986760 16757204
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.9411141357
MESH:D009369 Neoplasms Fluorouracil 8.9418600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.9417405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.3016359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416500647 16929163 15113037 19003803
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8211222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.8220603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1717292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1718626508 19082440
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2615538739 18722050 16160472 18286688
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9111738929 16876388 14763951 15475178 1511512 17978042 3137016 11044598
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4720155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4719015929 17522103 16951190 17498489 16424979 19084572 18396642 15786421 18567086 17172411
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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