AutismKB 2.0

Annotation Detail for UGT1A4


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Basic Information Top
Gene Symbol:UGT1A4 ( HUG-BR2,UDPGT,UDPGT 1-4,UGT1D )
Gene Full Name: UDP glucuronosyltransferase 1 family, polypeptide A4
Band: 2q37.1
Quick LinksEntrez ID:54657; OMIM: 606429; Uniprot ID:UD14_HUMAN; ENSEMBL ID: ENSG00000167165,ENSG00000240224,ENSG00000241119,EN; HGNC ID: 12536
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-221nicotine degradation III
PWY66-201nicotine degradation II
Pathway IDPathway Name
hsa00830Retinol metabolism
hsa00140Steroid hormone biosynthesis
hsa00860Porphyrin and chlorophyll metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa00040Pentose and glucuronate interconversions
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
hsa00053Ascorbate and aldarate metabolism
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Biological oxidations
No data
No data
Pathway IDPathway Name
500211Glucuronidation
Related Diseases/Disorders Top
No data
No data
Desease Name
NNAL-glucuronidating activities
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid UGT1A4 protein results in increased glucuronidation of 15-hydroxy-5,8,11,13-eicosatetraenoic acidincreases glucuronidation 15231852
C033146 1-hydroxypyrene UGT1A4 protein results in increased glucuronidation of 1-hydroxypyreneincreases glucuronidation 15802387
C055987 20-hydroxy-5,8,11,14-eicosatetraenoic acid UGT1A4 protein results in increased glucuronidation of 20-hydroxy-5,8,11,14-eicosatetraenoic acidincreases glucuronidation 15231852
C060533 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine UGT1A4 protein results in increased glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridineincreases glucuronidation 15310245
C006757 4-biphenylamine UGT1A4 protein results in increased glucuronidation of 4-biphenylamineincreases glucuronidation 15840509
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone UGT1A4 gene polymorphism results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases glucuronidation 14871856
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone UGT1A4 protein results in increased glucuronidation of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneincreases glucuronidation 14871856
C033541 afloqualone Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]decreases reaction|increases glucuronidation 15475412
C033541 afloqualone UGT1A4 protein results in increased glucuronidation of afloqualoneincreases glucuronidation 15475412
D000738 Androsterone UGT1A4 protein SNP results in increased glucuronidation of Androsterone analogincreases glucuronidation 15708967
D016718 Arachidonic Acid UGT1A4 protein results in increased glucuronidation of Arachidonic Acidincreases glucuronidation 15231852
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased activity of UGT1A4 proteinincreases activity 17065433
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of UGT1A4 mRNAincreases expression 17851650
D003024 Clozapine UGT1A4 protein SNP results in increased glucuronidation of Clozapineincreases glucuronidation 15708967
D003367 Cotinine UGT1A4 protein results in increased glucuronidation of Cotinineincreases glucuronidation 14570768
16141602
D004008 Diclofenac UGT1A4 protein results in increased glucuronidation of Diclofenacincreases glucuronidation 15843492
D005204 Farnesol UGT1A4 protein results in increased glucuronidation of Farnesolincreases glucuronidation 15320866
D005480 Flurbiprofen UGT1A4 protein results in increased glucuronidation of Flurbiprofenincreases glucuronidation 15843492
C001419 hydroxyphenytoin UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoindecreases activity|increases glucuronidation 15855726
D007099 Imipramine UGT1A4 protein affects the metabolism of Imipramineaffects metabolic processing 15286053
D007099 Imipramine UGT1A4 protein results in increased glucuronidation of Imipramineincreases glucuronidation 14570768
9264550
D007099 Imipramine UGT1A4 protein SNP results in increased glucuronidation of Imipramineincreases glucuronidation 15708967
D007213 Indomethacin UGT1A4 protein results in increased glucuronidation of Indomethacinincreases glucuronidation 15843492
D007660 Ketoprofen UGT1A4 protein results in increased glucuronidation of Ketoprofenincreases glucuronidation 15843492
C047781 lamotrigine [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
C047781 lamotrigine [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
C047781 lamotrigine [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
C047781 lamotrigine UGT1A4 protein results in increased glucuronidation of lamotrigineincreases glucuronidation 19845433
17151188
D008727 Methotrexate Methotrexate results in increased expression of UGT1A4 mRNAincreases expression 20854796
D009538 Nicotine UGT1A4 protein results in increased glucuronidation of Nicotineincreases glucuronidation 14570768
16141602
C010257 N'-nitrosoanabasine UGT1A4 protein results in increased glucuronidation of N'-nitrosoanabasineincreases glucuronidation 18238858
C032978 N'-nitrosoanatabine UGT1A4 protein results in increased glucuronidation of N'-nitrosoanatabineincreases glucuronidation 18238858
C008655 N'-nitrosonornicotine UGT1A4 protein results in increased glucuronidation of N'-nitrosonornicotineincreases glucuronidation 18238858
D010634 Phenobarbital Phenobarbital results in increased activity of UGT1A4 proteinincreases activity 19845433
D010634 Phenobarbital [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
C006253 pirinixic acid pirinixic acid results in increased activity of UGT1A4 proteinincreases activity 19845433
C006253 pirinixic acid [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
C006253 pirinixic acid pirinixic acid results in increased expression of UGT1A4 mRNAincreases expression 17151188
C006253 pirinixic acid pirinixic acid results in increased expression of UGT1A4 proteinincreases expression 17151188
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in increased activity of UGT1A4 proteinincreases activity 16155002
19845433
D011285 Pregnenolone Carbonitrile [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigineincreases activity|increases glucuronidation 19845433
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in increased expression of UGT1A4 mRNAincreases expression 16155002
D011285 Pregnenolone Carbonitrile Pregnenolone Carbonitrile results in increased expression of UGT1A4 proteinincreases expression 16155002
D000644 Quaternary Ammonium Compounds UGT1A4 protein results in increased glucuronidation of Quaternary Ammonium Compoundsincreases glucuronidation 9264550
C046297 sarsasapogenin UGT1A4 protein SNP results in decreased glucuronidation of sarsasapogenindecreases glucuronidation 15708967
D013467 Sulindac UGT1A4 protein results in increased glucuronidation of Sulindacincreases glucuronidation 15843492
C025463 sulindac sulfone UGT1A4 protein results in increased glucuronidation of sulindac sulfoneincreases glucuronidation 15843492
C115070 SX 3030 UGT1A4 protein results in increased glucuronidation of SX 3030increases glucuronidation 15013842
C115070 SX 3030 UGT1A4 protein results in increased glycosylation of SX 3030increases glycosylation 15013842
D013629 Tamoxifen UGT1A4 protein results in increased glucuronidation of Tamoxifenincreases glucuronidation 15135306
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of UGT1A4 proteinincreases activity 16155002
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UGT1A4 mRNAincreases expression 16155002
18433817
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UGT1A4 proteinincreases expression 16155002
D013749 Tetrachlorodibenzodioxin UGT1A4 promoter SNP affects the susceptibility to Tetrachlorodibenzodioxinaffects response to substance 18433817
D014268 Trifluoperazine Trifluoperazine inhibits the reaction [UGT1A4 protein results in increased glucuronidation of afloqualone]decreases reaction|increases glucuronidation 15475412
D014268 Trifluoperazine UGT1A4 protein results in increased glucuronidation of Trifluoperazineincreases glucuronidation 15135306
15475412
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.7314745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.7314745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 12.1012039119
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 12.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.1011752688 14514962 15322242
MESH:D058186 Acute Kidney Injury Diclofenac 8.287897758
MESH:D058186 Acute Kidney Injury Sulindac 8.287897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.7718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6320127859 20464547
MESH:D000230 Adenocarcinoma Indomethacin 6.6316537180
MESH:D000230 Adenocarcinoma Sulindac 6.6311910360
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 14.2316176798
MESH:D000236 Adenoma Benzo(a)pyrene 14.236695378
MESH:D000236 Adenoma Indomethacin 14.2311497255
MESH:D000236 Adenoma Sulindac 14.2310223192
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.0817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.0816835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 14.6410680582
MESH:D011125 Adenomatous Polyposis Coli Sulindac 14.6411874996 11535846 16460482 19003578 17611924 15623613 12394442
MESH:D011125 Adenomatous Polyposis Coli sulindac sulfone 14.6416150858
MESH:D000380 Agranulocytosis Clozapine 4.6816160616 12649775 14617031
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9817225004
MESH:D000544 Alzheimer Disease Indomethacin 4.4117627676 15579461
MESH:D000544 Alzheimer Disease Nicotine 4.4116627626
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6211748828
MESH:D001014 Aortic Aneurysm Indomethacin 4.4910231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.4719183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.4710388637
MESH:D018771 Arthralgia Indomethacin 4.782160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.7311248219
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.7317286800
MESH:D001321 Autistic Disorder Arachidonic Acid 3.0718582451
MESH:D001477 Bartter Syndrome Indomethacin 4.6110684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5215746008
MESH:D001913 Bowen's Disease Sulindac 4.9711207687
MESH:D001929 Brain Edema Indomethacin 4.6411481608
MESH:D002545 Brain Ischemia Indomethacin 4.0412524144
MESH:D001943 Breast Neoplasms 4-biphenylamine 4.3817671175
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4.3820146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.3820146248 17474063
MESH:D001943 Breast Neoplasms Indomethacin 4.3817401462
MESH:D001943 Breast Neoplasms Methotrexate 4.3816978400
MESH:D001943 Breast Neoplasms Sulindac 4.3816642371
MESH:D001943 Breast Neoplasms Tamoxifen 4.3817261762 18855134 19189210 18629630 19115204 19155303 16873071 20005174 15565566 18815881 21152245 19011961 20390343 19066611 19487384 20859285 19410462 18351453 21138602 16273361 19288272 18821012 20544844 20135344 19200415 17242785 19189212 16818667 17049068 19103187 17440819 20065188 19289846 19221464 15668708 18997820 17893378 18425577 19059307 19142967 11161223 19084267 18984771 16202921 19244106
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3820435547
MESH:D002056 Burns Indomethacin 4.3310459503
MESH:D002100 Cachexia Indomethacin 4.6211239499 15141370 15625704 16537180
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1319066611
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.2916391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.291701930 20935162 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.2916924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3511053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9714736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfone 3.9518758305
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1917341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3720419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.3712636206 15482327
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2917572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1516120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 4-biphenylamine 4.4915746073
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.884080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002764 Cholecystitis Indomethacin 4.7811181007
MESH:D002779 Cholestasis pirinixic acid 2.5519176532
MESH:D043171 Chromosomal Instability 4-biphenylamine 6.6217671175
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9416354765 15340226 12621046 8697196 15668235
MESH:D003072 Cognition Disorders Clozapine 4.5917123785
MESH:D003110 Colonic Neoplasms Indomethacin 3.9511260862 15936596 15637740 15786552 15963497 15625704
MESH:D003110 Colonic Neoplasms Sulindac 3.9512458338 12902858
MESH:D015179 Colorectal Neoplasms 4-biphenylamine 4.6617671175
MESH:D015179 Colorectal Neoplasms Indomethacin 4.6612606626 17054584 18059344 11197048
MESH:D015179 Colorectal Neoplasms Sulindac 4.6611076880 18059344 11197048 10666051
MESH:D015179 Colorectal Neoplasms sulindac sulfone 4.6618059344 11197048 10666051 10416599
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7417141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.3317302372
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.629562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6210048152 20055451 15322242
MESH:D003550 Cystic Fibrosis Methotrexate 3.9119747007
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9919031437
MESH:D003866 Depressive Disorder Imipramine 4.5120305041
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003882 Dermatomyositis Methotrexate 4.7620191521
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.1616402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1619279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.8212861449 17621415
MESH:D003967 Diarrhea Indomethacin 3.447237001 7907874
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1715331141
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 3.6617851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4811462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7718446180 12774134 18043480 16326151 17190690 16133044
MESH:D004381 Duodenal Ulcer Indomethacin 3.7817151854 17202747 17351913 11595431 17329845 11595415 11535926 11991626 17045617 10671773 16699067
MESH:D050171 Dyslipidemias Clozapine 3.9116402076
MESH:D004421 Dystonia Phenobarbital 3.651851702
MESH:D020821 Dystonic Disorders Nicotine 5.5417881519
MESH:D004487 Edema Arachidonic Acid 27.449831321 9599246 16716910 11698051 15177302 7990266
MESH:D004487 Edema Diclofenac 27.4416273134
MESH:D004487 Edema Imipramine 27.4412798668
MESH:D004487 Edema Indomethacin 27.4419703484 7990266 7907874 10653021 8985016 16100529 8273558
MESH:D004487 Edema Ketoprofen 27.447990266
MESH:D004487 Edema pirinixic acid 27.4412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 27.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.1819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8019155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Indomethacin 13.4915652904
MESH:D004715 Endometriosis Sulindac 13.4915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.499294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.1218509659
MESH:D004751 Enteritis Indomethacin 4.3617763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6117980183
MESH:D004802 Eosinophilia Indomethacin 3.6911298111
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 5.7920235791
MESH:D004831 Epilepsies, Myoclonic lamotrigine 10.2717275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.273659116
MESH:D004828 Epilepsies, Partial lamotrigine 9.4017116037
MESH:D004828 Epilepsies, Partial Phenobarbital 9.403922381 11558140
MESH:D004827 Epilepsy lamotrigine 6.7119668019
MESH:D004827 Epilepsy Phenobarbital 6.7120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.236401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.887750514
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 6.4516499746
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.643659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7716530937
MESH:D004938 Esophageal Neoplasms Indomethacin 6.7711005569
MESH:D004938 Esophageal Neoplasms Sulindac 6.7712235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7311564622
MESH:D005234 Fatty Liver pirinixic acid 6.5519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 6.5514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0811858732
MESH:D005334 Fever Arachidonic Acid 8.5011852909
MESH:D005334 Fever Indomethacin 8.5017627676 10431976 11852909
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.6814745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.6814745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.3719069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.3719069698
MESH:D005354 Fibrosarcoma Indomethacin 4.5110962813
MESH:D005355 Fibrosis Indomethacin 7.5917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5920067830
MESH:D005499 Folliculitis Indomethacin 4.7811298111
MESH:D005756 Gastritis Indomethacin 4.3615046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6511910360
MESH:D005909 Glioblastoma Indomethacin 3.3212870263
MESH:D005910 Glioma Indomethacin 3.0718371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9811849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2110696789
MESH:D006073 Gout Indomethacin 4.9711248219
MESH:D006086 Graft vs Host Disease Methotrexate 4.7816518429
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.4915482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.3020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0011000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3215135802
MESH:D006521 Hepatitis, Chronic Diclofenac 5.2914986274
MESH:D006529 Hepatomegaly Phenobarbital 12.2316109766
MESH:D006529 Hepatomegaly pirinixic acid 12.2319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.2316120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6615340226 8697196 18606429 16354765 16959395
MESH:D006930 Hyperalgesia Indomethacin 3.4812727271
MESH:D034321 Hyperamylasemia Indomethacin 5.3317883296
MESH:D006940 Hyperemia Indomethacin 4.6212524144
MESH:D006943 Hyperglycemia pirinixic acid 2.8520558911
MESH:D006948 Hyperkinesis Clozapine 4.5316046005
MESH:D006949 Hyperlipidemias Indomethacin 3.8117546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7618670907 18850075
MESH:D007077 Ileal Diseases Indomethacin 4.6418306037 10574470
MESH:D007079 Ileitis Indomethacin 4.9716133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9816133044
MESH:D007249 Inflammation Arachidonic Acid 25.069831321 15177302 17371808
MESH:D007249 Inflammation Diclofenac 25.0616273134
MESH:D007249 Inflammation Flurbiprofen 25.0611099482
MESH:D007249 Inflammation Imipramine 25.0612798668
MESH:D007249 Inflammation Indomethacin 25.0612568917 3291741 7812673
MESH:D007249 Inflammation Sulindac 25.063291741
MESH:D007249 Inflammation Tamoxifen 25.0619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 25.0612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.3816306350
MESH:D007410 Intestinal Diseases Indomethacin 3.9510210152 17329856 15610444 11686837 17994277 15831440 11855677 11713966 18236018
MESH:D007414 Intestinal Neoplasms Sulindac 4.3112663524 12628509 12584176 10223192 12351151 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.6412394442 11245490
MESH:D019586 Intracranial Hypertension Indomethacin 4.9815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0016580747
MESH:D007579 Jejunal Diseases Indomethacin 4.6416133968 18306037 10574470
MESH:D007674 Kidney Diseases Indomethacin 3.0517190690
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7418625569
MESH:D007805 Language Development Disorders Methotrexate 4.759562676
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6011703811 10320625 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.6415631656 16572323 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5718360721
MESH:D007964 Leukocytosis Indomethacin 4.9816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.3317980183
MESH:D008064 Lipidoses Clozapine 11.8317567588
MESH:D008064 Lipidoses Imipramine 11.8317567588 15342952
MESH:D008064 Lipidoses Tamoxifen 11.8315342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.3311479899
MESH:D008103 Liver Cirrhosis Methotrexate 6.2514986274
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2521047994
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.9812468960
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.5118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.5115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.5118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.5112878042
MESH:D008107 Liver Diseases Diclofenac 6.2314566034 16867024
MESH:D008107 Liver Diseases Phenobarbital 6.2319363144
MESH:D008107 Liver Diseases Sulindac 6.2316867024 14986274
MESH:D008113 Liver Neoplasms 4-biphenylamine 19.5215761837
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 19.5215890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 19.5221137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 19.5219482888 15975961 19073162 8742319 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 19.5215890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 19.5216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.5216984957
MESH:D008114 Liver Neoplasms, Experimental 4-biphenylamine 8.6711376689
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 8.676150874 1399818 2563599 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6712151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.6318516814
MESH:D008175 Lung Neoplasms 4-biphenylamine 9.8617671175
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 9.8614755239 16401635 16061637 12438228 18508827 15172992 9255578 17139156 18813816 19931552 15893417
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 9.8620064080 18520028 6695378 17053015 20135361 20464547 20869020 18816296 18569708
MESH:D008175 Lung Neoplasms Indomethacin 9.8616537180 11497255 11053908
MESH:D008175 Lung Neoplasms Sulindac 9.8619359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 9.8618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.8619555203 11884234
MESH:D008223 Lymphoma Methotrexate 3.6817352296
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.3914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.1619453300
MESH:D008545 Melanoma Sulindac 3.3716642371
MESH:D008545 Melanoma Tamoxifen 3.3712393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8015990972
MESH:D001523 Mental Disorders Clozapine 7.4016856516
MESH:D001523 Mental Disorders Imipramine 7.4016856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.1019142101
MESH:D008708 Methemoglobinemia 4-biphenylamine 5.0612030840
MESH:D008881 Migraine Disorders Indomethacin 3.4011903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6916381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.6912636206
MESH:D052016 Mucositis Methotrexate 4.9017488658
MESH:D009135 Muscular Diseases pirinixic acid 3.1416239165
MESH:D009203 Myocardial Infarction pirinixic acid 1.9819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.0917484760
MESH:D009362 Neoplasm Metastasis Indomethacin 5.4116537180 11053908 11239499
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.2111141357
MESH:D009369 Neoplasms Nicotine 7.2116365874
MESH:D009369 Neoplasms pirinixic acid 7.2117405874
MESH:D009374 Neoplasms, Experimental Indomethacin 3.7710663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6119196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Nicotine 4.6116365874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8514600291
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.8912349958
MESH:D019636 Neurodegenerative Diseases Sulindac 7.8916850258 17266991
MESH:D009765 Obesity Clozapine 4.3519142110 18515891
MESH:D009765 Obesity pirinixic acid 4.3520558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.786374098
MESH:D010003 Osteoarthritis Diclofenac 7.4418287210
MESH:D010003 Osteoarthritis Indomethacin 7.447009135
MESH:D010018 Osteomalacia Phenobarbital 3.9817016548
MESH:D010146 Pain Diclofenac 13.8113679232
MESH:D010146 Pain Imipramine 13.8112798668
MESH:D010146 Pain Indomethacin 13.8113679232 3291741 17440234 17627676
MESH:D010146 Pain Sulindac 13.813291741
MESH:D010149 Pain, Postoperative Indomethacin 4.2912538197 18702446
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.0012384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.0016965848
MESH:D010190 Pancreatic Neoplasms Sulindac 8.0011504793 16820089
MESH:D010195 Pancreatitis Indomethacin 3.5817883296 15028970
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.3316537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7912349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.3311903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7711148446
MESH:D010518 Periodontitis Indomethacin 4.5317225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2018163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.302563599
MESH:D047928 Premature Birth Indomethacin 4.7517000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8111896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.2817292933
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.2817409433
MESH:D011471 Prostatic Neoplasms sulindac sulfone 2.2815570007 17908994
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2815067354
MESH:D011507 Proteinuria Indomethacin 3.8111849393
MESH:D019310 Pseudolymphoma Phenobarbital 4.1112752131
MESH:D011565 Psoriasis Methotrexate 3.3017410198
MESH:D011618 Psychotic Disorders Clozapine 3.9115331141
MESH:D051437 Renal Insufficiency Methotrexate 4.3417352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4718990726
MESH:D012559 Schizophrenia Clozapine 2.6817123785 16141801 20521326 17667964 17726453 20168265 20452607 18855531 20521320 19369910 20107430 20580759 11151749 11763009 18806925
MESH:D012640 Seizures lamotrigine 8.779844417 16499746
MESH:D012640 Seizures Nicotine 8.7717873105
MESH:D012640 Seizures Phenobarbital 8.773137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.446407741
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 6.2220485159 19668019
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.8516192470
MESH:D012892 Sleep Deprivation Imipramine 5.8119798453
MESH:D013088 Spermatocele Tamoxifen 3.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6619457130
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 5.7320235791
MESH:D013272 Stomach Diseases Indomethacin 4.0410486359 15038085 18209964 18545984 10192188 17638125 10215738 16280098 16184426 16113693 15472012 17207306 17160473
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.4720155912 2093021
MESH:D013274 Stomach Neoplasms Indomethacin 3.4715609394
MESH:D013274 Stomach Neoplasms N'-nitrosonornicotine 3.4718456281
MESH:D013276 Stomach Ulcer Indomethacin 3.2617135157 1323529 14567935 18193104 12787963 17657623 17627676 16631530 18209962 17895592 18087811 10878458 15138204 16934674 11595415 11906479 12500499 10423059 18181030 17977527 16169175 11595431 11145282 17918041 12498302 18431645 16252198 12077510 18543354 16150113 17654042 18726076 15255614 10750652 11523592 18299717 11729361 15104355 18237397 16755016 16397915 12467913
MESH:D013576 Syndactyly Methotrexate 4.679562676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5112697716
MESH:D013964 Thyroid Neoplasms Indomethacin 6.4514736730 11352223 18791128
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.451399818
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.4516720336 16785264 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.0818041664 15735609 18305452 17979512
MESH:D014456 Ulcer Indomethacin 4.5117380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 4-biphenylamine 7.6112376482 6654951 11144890 17671175
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.6117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.6117572228 8653321 16712894
MESH:D014594 Uterine Neoplasms Sulindac 4.2418645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2112125929
MESH:D014839 Vomiting Indomethacin 4.3611897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8615886252
MESH:D015430 Weight Gain Clozapine 4.1516402076 16141801 20107430 20521320 20564506 17502770
MESH:D015431 Weight Loss Clozapine 4.7017933447
Pathway ID Pathway Name
KEGG:00053 Ascorbate and aldarate metabolism
REACT:13433 Biological oxidations
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
KEGG:00514 Other types of O-glycan biosynthesis
KEGG:00040 Pentose and glucuronate interconversions
KEGG:00860 Porphyrin and chlorophyll metabolism
KEGG:00830 Retinol metabolism
KEGG:00500 Starch and sucrose metabolism
KEGG:00140 Steroid hormone biosynthesis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37179
    • Releated gene ID Related gene Name
    PA37179UGT1A4
    Releated disease ID Related disease Name
    PA443937Drug Toxicity
    PA445062Neoplasms
    PA447281Gilbert's syndrome
    PA444511Hyperbilirubinemia
    Releated drug ID Related drug Name
    PA165110775SN-38
    PA450947phenytoin
    PA450496midazolam
    PA450626nicotine
    PA450626nicotine
    PA450913phenol
    PA451581tamoxifen
    PA450085irinotecan
    PA448964chlorpromazine
    PA449061clozapine
    PA449969imipramine
    PA450164lamotrigine
    PA450369meperidine
    PA450688olanzapine
    PA165110778Tipifarnib
    Drug Bank Top
    No data
    Drugbank ID Action Drug Name Description
    DB00363 substrate Clozapine Antipsychotics;Serotonin Antagonists;Antipsychotic Agents;GABA Antagonists
    DB00555 - Lamotrigine Antidepressants;Anticonvulsants;Analgesics;Calcium Channel Blockers;Antimanic Agents;Excitatory Amino Acid Antagonists
    DB00831 - Stelabid No 2 Antiemetics;Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00910 substrate Paricalcitol
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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