AutismKB 2.0

Annotation Detail for WDR74


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Basic Information Top
Gene Symbol:WDR74 ( FLJ10439,FLJ21730 )
Gene Full Name: WD repeat domain 74
Band: 11q12.3
Quick LinksEntrez ID:54663; OMIM: NA; Uniprot ID:WDR74_HUMAN; ENSEMBL ID: ENSG00000133316; HGNC ID: 25529
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of WDR74 mRNAaffects expression 17562736
C004541 biochanin A biochanin A results in decreased expression of WDR74 mRNAdecreases expression 12111696
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of WDR74 mRNAaffects expression 17555576
D018038 Sodium Selenite Sodium Selenite results in increased expression of WDR74 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of WDR74 mRNAaffects expression 17555576
D014212 Tretinoin Tretinoin results in decreased expression of WDR74 mRNAdecreases expression 16604517
D014635 Valproic Acid Valproic Acid results in decreased expression of WDR74 mRNAdecreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7315885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.7316412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8619460635 18558336 16609825 18985861 15238991 17507914 18396377 17688650 18177632 18316065 18940202 17157402 19232924 20603192 18775368
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001943 Breast Neoplasms Tamoxifen 2.1416202921 19410462 19221464 17049068 19142967 19200415 18855134 15668708 11161223 17440819 18821012 19487384 19059307 21152245 20065188 21138602 19289846 19288272 20005174 17261762 18997820 20859285 17242785 19084267 19066611 20390343 16818667 19011961 18984771 18815881 20135344 16873071 17893378 18425577 19115204 19189212 20544844 16273361 18629630 19103187 19155303 18351453 19244106 19189210 15565566
MESH:D001943 Breast Neoplasms Tretinoin 2.1416166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.741917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3516051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0716919318 16105132 15861022 17681005 17333356 11677210 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.758800419 16925845 9125849 9224671 10589399 9211117 17551590 9142499 14991402 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7517688650 16575769 8888407
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6512153990 16109766 12540782 19085960 11743745 12958197 11461765 10774834 19416960 11287661 14550746 12705907 10663392 2444490 19739265 19164858 18713872 17522070 11739529 11421492 11529661 16177239 12594235 12392966 16081117 15619225 18071297 14725611 16781746 19420014 16485898 11834606 16227642 16393943 17906064 15968718 19370779 14986274 19923254 10915739 17562736
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6515131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.651733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0117893378 16202921 20544844 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 8.0116569247
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8115345470
MESH:D005234 Fatty Liver Tamoxifen 14.8119224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 14.8119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma biochanin A 8.2216598420
MESH:D005909 Glioblastoma Tretinoin 8.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0214991402 9664655
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1815992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.0216294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3212679006 17107899 19225113 16140955 16935935 17649720 19029980 16331271 17506722 9834237 19075265 17712046 17361223 16766008 17301526 19642359 17217047 16891316 19035177 15748426 17339181 17294898 16823087 16788101 17368321
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5618397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6811587558 19460945 19014921 12587719 16610002 16611625 19784758 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 2.3016684651
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 19196723 19196722 11731420 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tamoxifen 3.4119393235 12393984
MESH:D008545 Melanoma Tretinoin 3.4116752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.8717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.8717596541
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Tretinoin 2.5216946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects Tretinoin 7.889142499
MESH:D009436 Neural Tube Defects Valproic Acid 7.8816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms biochanin A 2.7312111696
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7318760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7315067354
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.9811422049 12752131
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 11.9016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.9019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9115475178 14763951 11044598 17978042 11738929 16876388 1511512 3137016
MESH:D012878 Skin Neoplasms Tretinoin 2.7216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4417572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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