AutismKB 2.0

Annotation Detail for TMEM106B


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Basic Information Top
Gene Symbol:TMEM106B ( FLJ11273,MGC33727 )
Gene Full Name: transmembrane protein 106B
Band: 7p21.3
Quick LinksEntrez ID:54664; OMIM: 613413; Uniprot ID:T106B_HUMAN; ENSEMBL ID: ENSG00000106460; HGNC ID: 22407
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
frontotemporal lobar degeneration
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM106B mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM106B mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of TMEM106B mRNAaffects expression 17484886
D003010 Clorgyline Clorgyline results in increased expression of TMEM106B mRNAincreases expression 19691856
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of TMEM106B mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of TMEM106B mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of TMEM106B mRNAincreases expression 18301758
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TMEM106B mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.936195326
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.937525203
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816097048 18705752 15721981 16050911 16124888 3786805 16011737 16192424 16227642 10355542 15673190 15700767
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7218788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.726705139 1701930 20935162 17173139 20007298
MESH:D002386 Cataract Acetaminophen 7.9410977129
MESH:D002386 Cataract Trinitrotoluene 7.9414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6115095906
MESH:D003490 Cyanosis Trinitrotoluene 5.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6614986274 14725611 12958197 10915739 2444490 10663392 19923254 12392966 16177239 17906064 16227642 11743745 19085960 18713872 17522070 11529661 19164858 11461765 16081117 16485898 15968718 10774834 11421492 17562736 16109766 16781746 11834606 19416960 12594235 12705907 19370779 14550746 11739529 19420014 11287661 15619225 12540782 19739265 12153990 16393943 18071297
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6617522070 3786805 6884620 11566570 21278145 19085960 2869522 10092053 10915739 3732212 7179309 19336974 16177239 9327722 16227642 6623471 15968718 7120509 7440962 15027814 4309450 15998439
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.6621346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.8020426865
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.8016805852 16510608 15623463 15264214 15150132 15547721 15547733 16704527 15878914
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.4912795759 61145 12631006 19224547 17595544 15959796 16045604 16239168
MESH:D005234 Fatty Liver pirinixic acid 8.4919236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D057174 Frontotemporal Lobar Degeneration marker/mechanism 20154673
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 16.4316109766
MESH:D006529 Hepatomegaly pirinixic acid 16.4319772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Trinitrotoluene 16.4315817613
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007248 Infertility, Male Trinitrotoluene 3.8312150543
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0416943688 16239168 11903743 17157831 11408273 21278145 17174718 16221502 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3815730626 15052691 18429990 18277467 12649538 16011737 17714472 18317297 14716496 16097048 12389079 16015684 12898905 12609069 17823541 18705752 12666154 14748882 16027843 18395095 18205269 15893842 15370692 18472332 14512876 20821823 17708605 15057751 12667390 14716833 17557913 18263696 15673190 17900296 12586293 17944888 17721639 11481614 12632512 15650968 13678700 15959796 15931870 16116963 18418968 18481824 16136751 16033810 17761835 18420326 17698563 17976157 18395914 18166357 15362042 14724832 15996030 17565644 12958196 18279442 15818738 18210741 15338365 18006644 18156304 18412020 17805973 14620537 15876570 18054572 15925388 12546737 17631135 18472094 18187930 16192424 17525996 17869086 12445418 17766677 12445421 17922224 12632514 16248980 16638106 15123356 18376398 18251166 17481882 17640975 18339082 10355542 12741479
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3815474484
MESH:D008107 Liver Diseases Acetaminophen 6.7911587558 16611625 19460945 12969438 12587719 16610002 19014921 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7915720792 15830285 17285989 16246199 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.7919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.8719294768
MESH:D008113 Liver Neoplasms Phenobarbital 7.8715975961 19812893 19073162 8742319 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.8720007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.451399818 18308698 2563599 17172636 6150874
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis Trinitrotoluene 5.1018551238
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases Trinitrotoluene 4.5617852074 12819281 14694615
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011471 Prostatic Neoplasms Clorgyline 4.2519691856
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures Phenobarbital 6.794039156 3137016 16876388 11442880
MESH:D012640 Seizures Trinitrotoluene 6.7918551238
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013163 Splenomegaly Trinitrotoluene 5.5115817613
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670756
    • No data
    Releated disease ID Related disease Name
    PA443853Dementia
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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