AutismKB 2.0

Annotation Detail for LRRN3


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Basic Information Top
Gene Symbol:LRRN3 ( FIGLER5,FLJ11129,NLRR-3,NLRR3 )
Gene Full Name: leucine rich repeat neuronal 3
Band: 7q31.1
Quick LinksEntrez ID:54674; OMIM: NA; Uniprot ID:LRRN3_HUMAN; ENSEMBL ID: ENSG00000173114; HGNC ID: 17200
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LRRN3 mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LRRN3 mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of LRRN3 mRNAaffects expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LRRN3 mRNAaffects expression 17484886
D003474 Curcumin Curcumin results in increased expression of LRRN3 mRNAincreases expression 17198877
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LRRN3 mRNAaffects cotreatment|decreases expression 18164116
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000236 Adenoma beta-Naphthoflavone 7.4419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.4410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3618056438 19052882 16434500 19061943 17162532 17620307
MESH:D019973 Alcohol-Related Disorders Curcumin 5.6017887948
MESH:D000544 Alzheimer Disease Curcumin 2.6715590663
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4918704882
MESH:D001327 Autoimmune Diseases Curcumin 4.9119761891
MESH:D002545 Brain Ischemia Curcumin 4.7916770732
MESH:D001932 Brain Neoplasms Curcumin 4.2417596214
MESH:D001943 Breast Neoplasms Curcumin 2.3218462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3217474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2016050911 15721981 16192424 15673190 16097048 18705752 10355542 15700767 3786805 16227642 16011737 16124888
MESH:D002277 Carcinoma Curcumin 4.0918593918
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1319418558 19919837 18494052 20514400 20007298 17138121 18971187 16878318 19822196 19383236 18056438 19208518 3581430 19171122 16698587 18506893 18785209 17173139 20101231 16328049 20432363 17162532 10737359 16288022 17428255 10672840 20512989 19107877 18665156 17055752 18691550 18788625 16540662 18393292 20524982 16569478 16681979 20727157 16779866 16935385 19519916 20214788 16807293 17978847 19335982 16502159 11831363 17761372 19394651 3084413 20935162 19052882 19539802 18210153 16830150 19701751 21159647 18978308 20084675
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0618414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8318462866
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3820889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.3817174075 7505956 21159647 2727394
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 20678249
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D003092 Colitis Curcumin 4.5916782535 18200517 16804969
MESH:D003103 Coloboma Curcumin 4.8818809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5416340194 19359593
MESH:D016510 Corneal Neovascularization Curcumin 5.3118497527
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.8118403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.8120387270
MESH:D003928 Diabetic Nephropathies Curcumin 4.2918204486
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.1710092053 9327722 16177239 16227642 3732212 7179309 19336974 4309450 15968718 2869522 7120509 10915739 15027814 17522070 6623471 21278145 19085960 7440962 11566570 6884620 15998439 3786805
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.1719107877
MESH:D004381 Duodenal Ulcer Curcumin 4.4317351913
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.1916045604 12631006 15959796 12795759 61145 16239168 17595544 19224547
MESH:D005234 Fatty Liver Curcumin 15.1919297423
MESH:D005234 Fatty Liver Diethylnitrosamine 15.1921071580 20387270
MESH:D005355 Fibrosis Carbon Tetrachloride 10.4018705752
MESH:D005355 Fibrosis Curcumin 10.4018705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.1118462866
MESH:D005909 Glioblastoma Curcumin 3.6717596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8618829502 18462866
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4617701891
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006937 Hypercholesterolemia Curcumin 4.3818704882
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Curcumin 5.7618403477 16956363 17151092
MESH:D007249 Inflammation Diethylnitrosamine 5.7618785209
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3118200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.5210783313
MESH:D007889 Leiomyoma Curcumin 4.9218555241
MESH:D007938 Leukemia Curcumin 3.3718462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.5316106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.1416106398
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1316239168 11408273 17334410 16943688 21278145 11903743 17157831 17174718 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.1318665156 18407596 18522880 19638242 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.7418376398 18339082 18412020 12667390 17869086 18420326 15931870 18395095 17708605 18263696 12632514 15057751 17805973 17944888 12898905 18317297 17557913 16116963 18472094 17900296 14716496 15650968 17481882 15959796 18210741 18705752 14620537 18472332 18006644 15052691 18054572 18279442 13678700 15123356 15818738 12632512 18205269 16027843 12546737 15362042 15925388 12445421 17922224 18277467 17698563 16097048 15730626 15893842 12389079 15996030 18395914 16011737 16638106 12609069 16248980 14748882 12445418 17721639 15338365 16033810 12649538 17631135 15370692 12958196 14512876 17565644 12666154 18481824 16136751 18418968 17714472 12741479 15673190 18187930 18251166 15876570 17761835 17525996 16015684 17976157 17823541 11481614 14716833 17766677 18429990 10355542 17640975 14724832 18166357 20821823 18156304 16192424 12586293
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7417355460 18705752 18006644
MESH:D008107 Liver Diseases Carbon Tetrachloride 7.0017285989 16246199 15720792 15830285 16964402
MESH:D008107 Liver Diseases Curcumin 7.0016956363
MESH:D008107 Liver Diseases Diethylnitrosamine 7.0017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9916899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.1121295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.1119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.1119073162 19638242 19427195 15175105 19256749 18978307 21167192 19499222 19426721 19254457 19850985 20101389 19255062 20118626 16942905 18648771 19551842 20452335 19833225 21278145 9163691 12112319 21047994 18977376 19090486 20137499 20434301 12771043 2422723 20501860 20405173 19294768 20492335 19812893 15885732 18644402 21071580 18754104 19690152 19996281 2862719 19642983 20583210 10737359
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 11.0118164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.0112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 11.0119004024 18544905 3124819 21159647 18093689 17174075 17854601 18079962 2563599 18775883 17942915 19539802 16842330 16267830 18282651 19009564 19126423 18164116 18308698 9362446 19519916 18253720
MESH:D008175 Lung Neoplasms Curcumin 2.7118462866 16243823 19359593
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.7120512841 20970405 6695378 21163286
MESH:D008223 Lymphoma Curcumin 3.8018462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.1116173963
MESH:D008545 Melanoma Curcumin 2.4518462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.5317263510
MESH:D009101 Multiple Myeloma Curcumin 3.7319372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3817962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7518495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.679029167 3581430
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.0512497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.1518462866
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D010024 Osteoporosis Curcumin 3.6518719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8919020741 18462866
MESH:D010190 Pancreatic Neoplasms Curcumin 5.7419196508 17440100 19401701
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.7416540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011471 Prostatic Neoplasms Curcumin 3.6318156803 18226269 10851300 12497104 18769126 11398177 15129424
MESH:D011656 Pulmonary Emphysema Curcumin 4.8319168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3810666014 18379247
MESH:D012509 Sarcoma Curcumin 4.4218462866
MESH:D018805 Sepsis Curcumin 4.3418389075
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Curcumin 3.8216631530 19188055
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9918593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.7318462866
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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