AutismKB 2.0

Annotation Detail for CROT


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CROT ( COT )
Gene Full Name: carnitine O-octanoyltransferase
Band: 7q21.12
Quick LinksEntrez ID:54677; OMIM: 606090; Uniprot ID:OCTC_HUMAN; ENSEMBL ID: ENSG00000005469; HGNC ID: 2366
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04146Peroxisome
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500820Beta-oxidation of pristanoyl-CoA
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CROT mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CROT mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in increased expression of CROT mRNAincreases expression 16648578
D000643 Ammonium Chloride Ammonium Chloride affects the expression of CROT mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CROT mRNAaffects cotreatment|decreases expression 18164116
C095105 bexarotene bexarotene results in increased expression of CROT mRNAincreases expression 16648578
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CROT mRNAaffects cotreatment|affects expression 17602206
D003314 Corn Oil Corn Oil affects the expression of CROT mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of CROT mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of CROT mRNAincreases expression 16357043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CROT mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CROT mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CROT mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of CROT mRNAdecreases expression 19619570
D007213 Indomethacin Indomethacin results in increased expression of CROT mRNAincreases expression 18299717
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CROT mRNAincreases expression 17681415
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of CROT mRNAincreases expression 16221955
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CROT mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of CROT mRNAincreases expression 17426115
16357043
18301758
C006253 pirinixic acid pirinixic acid results in increased expression of CROT proteinincreases expression 15226431
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in increased expression of CROT mRNAincreases expression 20056577
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CROT mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CROT mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CROT mRNAincreases expression 19465110
D013752 Tetracycline Tetracycline results in increased expression of CROT mRNAincreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Estradiol 4.5411473722
MESH:D000230 Adenocarcinoma Indomethacin 4.5416537180
MESH:D000236 Adenoma beta-Naphthoflavone 11.1719389873
MESH:D000236 Adenoma Diethylnitrosamine 11.1710737359 6695378
MESH:D000236 Adenoma Indomethacin 11.1711497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.0817162532 19061943 16434500 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0816835633
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3417225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6917627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.8110231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8310388637
MESH:D001161 Arteriosclerosis Dietary Fats 3.8515238619
MESH:D018771 Arthralgia Indomethacin 5.142160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8111248219
MESH:D001321 Autistic Disorder Acetaminophen 2.3618445737
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.3619211157
MESH:D001477 Bartter Syndrome Indomethacin 4.9410684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001929 Brain Edema Indomethacin 5.0011481608
MESH:D002545 Brain Ischemia Indomethacin 4.3812524144
MESH:D001943 Breast Neoplasms alitretinoin 3.7516344269
MESH:D001943 Breast Neoplasms bexarotene 3.7516344269 16818667
MESH:D001943 Breast Neoplasms Dietary Fats 3.7520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7517474063
MESH:D001943 Breast Neoplasms Estradiol 3.7517289903 16675129 19861407 14630087 12948864 17018787 18497071 17261762
MESH:D001943 Breast Neoplasms Indomethacin 3.7517401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7520435547
MESH:D002056 Burns Indomethacin 4.6610459503
MESH:D002100 Cachexia Indomethacin 4.9715141370 16537180 11239499 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.803084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.8011831363 19107877 18056438 19052882 16698587 19919837 16830150 17761372 20935162 10672840 16807293 20514400 16540662 18210153 16681979 18971187 18691550 16502159 17428255 16935385 18785209 19208518 18494052 18788625 20084675 18665156 19394651 18393292 20432363 20214788 19519916 17055752 20524982 10737359 18978308 19539802 16288022 16569478 3581430 16328049 19171122 17162532 19701751 19383236 17138121 17978847 18506893 16878318 19822196 20101231 20007298 20727157 16779866 20512989 17173139 19418558 21159647 3084413 19335982
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.8016924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.8016391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6911053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.3211352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2116247446
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3517341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.8415482327 12636206
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.766135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.7612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.7621159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.7618566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2016835633
MESH:D002764 Cholecystitis Indomethacin 5.1411181007
MESH:D002779 Cholestasis Cyclosporine 7.6519486331
MESH:D002779 Cholestasis pirinixic acid 7.6519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Indomethacin 2.5815625704 15936596 15963497 15786552 15637740 11260862
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3511197048 17054584 18059344 12606626
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.6917302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3719279558
MESH:D003967 Diarrhea Indomethacin 3.757907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.8821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8811287661 12392966 15968718 16393943 19085960 16781746 12705907 11743745 16177239 12540782 17906064 10774834 11421492 14550746 17522070 11739529 10915739 19164858 19739265 17562736 15619225 19416960 16227642 19370779 19923254 14725611 11834606 18713872 12594235 12153990 2444490 16485898 16109766 18071297 16081117 10663392 14986274 11529661 19420014 11461765 12958197
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.8819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8820420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 11.8817522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.1118446180 12774134 16326151 16133044 17190690 18043480
MESH:D004381 Duodenal Ulcer Indomethacin 4.0911595415 11991626 17351913 17151854 17202747 17045617 11595431 17329845 10671773 11535926 16699067
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema Indomethacin 16.147907874 10653021 16100529 8985016 8273558 19703484 7990266
MESH:D004487 Edema perfluorooctanoic acid 16.1417259670 12083418
MESH:D004487 Edema pirinixic acid 16.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.9511473722 18566989 19148513
MESH:D004715 Endometriosis Indomethacin 8.9415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.9410568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.4718509659
MESH:D004751 Enteritis Indomethacin 4.7210567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9417980183
MESH:D004802 Eosinophilia Indomethacin 4.0111298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0916302075
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8011005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Cyclosporine 24.2419224547
MESH:D005234 Fatty Liver Dietary Fats 24.2417967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 24.2421071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 24.2419236843 20131406
MESH:D005234 Fatty Liver Tetracycline 24.2416917069 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005334 Fever Indomethacin 4.0817627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.8610962813
MESH:D005355 Fibrosis Cyclosporine 20.8612168785 12639820
MESH:D005355 Fibrosis Dietary Fats 20.8618296743
MESH:D005355 Fibrosis Indomethacin 20.8617994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.8620067830
MESH:D005499 Folliculitis Indomethacin 5.1411298111
MESH:D005756 Gastritis Acetaminophen 11.0516983495
MESH:D005756 Gastritis Indomethacin 11.0515046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Indomethacin 3.5312870263
MESH:D005910 Glioma Indomethacin 3.2116487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2511849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006073 Gout Indomethacin 5.3211248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7115482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5315633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6415135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 14.243609246
MESH:D006529 Hepatomegaly pirinixic acid 14.2419772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.2416120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 12.9516870215
MESH:D006930 Hyperalgesia Indomethacin 12.9512727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.9512083418
MESH:D034321 Hyperamylasemia Indomethacin 5.6917883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006940 Hyperemia Indomethacin 4.9712524144
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.2021332399
MESH:D006949 Hyperlipidemias Indomethacin 9.2017546600
MESH:D006968 Hypersensitivity, Delayed Corn Oil 5.7811484837
MESH:D006973 Hypertension Cyclosporine 4.8910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8918670907 18850075
MESH:D007077 Ileal Diseases Indomethacin 5.0018306037 10574470
MESH:D007079 Ileitis Indomethacin 5.3210651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3416133044
MESH:D007249 Inflammation Dietary Fats 15.6420412841
MESH:D007249 Inflammation Diethylnitrosamine 15.6418785209
MESH:D007249 Inflammation Indomethacin 15.643291741 7812673 12568917
MESH:D007249 Inflammation perfluorooctanoic acid 15.6412083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.6412878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.1211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.1216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.1216306350
MESH:D007410 Intestinal Diseases Indomethacin 4.2915610444 11855677 10210152 11686837 17994277 15831440 18236018 11713966 17329856
MESH:D019586 Intracranial Hypertension Indomethacin 5.3415241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007579 Jejunal Diseases Indomethacin 5.0010574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6016144296
MESH:D007674 Kidney Diseases Acetaminophen 14.2312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.238314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 14.2315618244
MESH:D007674 Kidney Diseases Indomethacin 14.2317190690
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.1516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.1512371664
MESH:D007680 Kidney Neoplasms Estradiol 12.1515610895
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8710320625 12228301 11703811
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8910785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6318360721
MESH:D007964 Leukocytosis Indomethacin 5.3416537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6917980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.198812269
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6911479899
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5518296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.5518407596 19638242 20032147 18665156 18522880
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.9018194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9012878042
MESH:D008107 Liver Diseases Acetaminophen 3.8719784758 12969438 19460945 16611625 16610002 12587719 11587558 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 21.677678174
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.6719389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 21.6717602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.6719812893 20583210 15175105 19996281 20118626 19255062 18978307 15885732 19294768 19256749 12112319 9163691 19551842 19833225 20501860 19642983 19850985 20405173 18977376 21167192 19254457 21071580 19090486 20492335 18644402 10737359 20101389 2862719 18754104 20137499 18648771 19690152 20434301 21047994 20452335 12771043 2422723 16942905 21278145 19426721 19427195 19638242 19499222 19073162
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 21.6714757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 21.6716377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.906135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.9018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.9021159647 19009564 18282651 18544905 19519916 18775883 19004024 2563599 17942915 17174075 18308698 18079962 18253720 19539802 16842330 17854601 9362446 16267830 18164116 3124819 19126423 18093689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.9012151625
MESH:D008175 Lung Neoplasms alitretinoin 6.5616413115
MESH:D008175 Lung Neoplasms bexarotene 6.5617849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5620970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Indomethacin 6.5616537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5619555203 11884234
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.1111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 6.1615591091 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1611807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D008881 Migraine Disorders Indomethacin 3.6411903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.9512636206
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.8318551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.909029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 5.9016537180 11239499 11053908
MESH:D009369 Neoplasms alitretinoin 5.1516946489
MESH:D009369 Neoplasms pirinixic acid 5.1517405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.1010663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.7519196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009395 Nephritis, Interstitial Tetracycline 4.769884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.3311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3314600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.8620387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 13.8612349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.919802331
MESH:D009765 Obesity Dietary Fats 4.4019632207 18457598 18674790 21332399 20518802 20132043 11836018 17217161 16723640
MESH:D009765 Obesity pirinixic acid 4.4020558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.146374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3916049721
MESH:D010003 Osteoarthritis Indomethacin 3.647009135
MESH:D010051 Ovarian Neoplasms Estradiol 2.2019401270
MESH:D010146 Pain Acetaminophen 6.6716870215
MESH:D010146 Pain Indomethacin 6.6717627676 17440234 3291741 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.6512538197 18702446
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4116540662
MESH:D010195 Pancreatitis Indomethacin 3.8815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6916537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6911903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.4011026799
MESH:D010437 Peptic Ulcer Indomethacin 5.1111148446
MESH:D010518 Periodontitis Indomethacin 4.8817225004
MESH:D017499 Porokeratosis alitretinoin 5.9816144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Corn Oil 15.2414668109
MESH:D011230 Precancerous Conditions Cyclosporine 15.2412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.242563599
MESH:D047928 Premature Birth Indomethacin 5.0917000239
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.5517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.5511222880 11118676 11399792 11896295
MESH:D017096 Prion Diseases Tetracycline 5.3810903871
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011507 Proteinuria Indomethacin 4.1211849393
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5018551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D013272 Stomach Diseases Indomethacin 4.3816280098 17207306 16184426 15472012 10192188 15038085 18545984 16113693 17638125 17160473 10215738 18209964 10486359
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.6118456281
MESH:D013274 Stomach Neoplasms Indomethacin 2.6115609394
MESH:D013276 Stomach Ulcer Indomethacin 3.5412077510 12787963 18209962 16252198 17895592 16169175 11595431 11145282 16631530 12500499 1323529 11595415 15138204 18726076 10423059 17654042 16934674 15255614 18431645 17657623 11906479 18193104 10878458 12467913 17977527 11523592 15104355 17135157 17918041 12498302 18181030 18237397 16755016 18299717 17627676 18543354 16397915 11729361 16150113 10750652 14567935 18087811
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.267505956
MESH:D013964 Thyroid Neoplasms Indomethacin 7.2614736730 18791128 11352223
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014456 Ulcer Indomethacin 4.8617380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2716049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2810091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D014839 Vomiting Indomethacin 4.7211897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00583 - L-Carnitine Vitamins (Vitamin B Complex);Nootropic Agents;Metabolite;Nutraceutical;Vitamin B Complex
DB02648 - (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium Vitamin B Complex
DB03684 - 2-Methyl-2,4-Pentanediol
DB03832 - 3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved