AutismKB 2.0

Annotation Detail for MANSC1


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Basic Information Top
Gene Symbol:MANSC1 ( 9130403P13Rik,FLJ10298,LOH12CR3 )
Gene Full Name: MANSC domain containing 1
Band: 12p13.2
Quick LinksEntrez ID:54682; OMIM: NA; Uniprot ID:MANS1_HUMAN; ENSEMBL ID: ENSG00000111261; HGNC ID: 25505
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MANSC1 mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MANSC1 mRNAdecreases expression 15336504
D004958 Estradiol Estradiol results in increased expression of MANSC1 mRNAincreases expression 20106945
C016340 o,p'-DDT o,p'-DDT results in decreased expression of MANSC1 mRNAdecreases expression 19371625
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MANSC1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of MANSC1 mRNAdecreases expression 19482888
C059514 resveratrol resveratrol results in decreased expression of MANSC1 mRNAdecreases expression 19371625
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MANSC1 mRNAdecreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.6515322242 11752688 14514962
MESH:D058186 Acute Kidney Injury resveratrol 4.1316538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4720464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 4.4711473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.296695378
MESH:D000236 Adenoma resveratrol 7.2915688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4417620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.4416835633
MESH:D000544 Alzheimer Disease resveratrol 2.6216162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental resveratrol 3.6617115116
MESH:D050197 Atherosclerosis resveratrol 3.4216873680 17967414
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D002545 Brain Ischemia resveratrol 4.6817600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 17289903 17018787 12948864 16675129 19861407 14630087 18497071
MESH:D001943 Breast Neoplasms resveratrol 1.9717651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8617173139 20935162 6705139 20007298 1701930
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.8616227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.9916675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9520419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.9516227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.6515458977
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2016354765 8697196 15668235 12621046 15340226
MESH:D003092 Colitis resveratrol 4.4916474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4916338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.9216507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 4.0016873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.8619279558
MESH:D003928 Diabetic Nephropathies resveratrol 9.8616286809
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema resveratrol 7.818985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.3517872969
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.2117923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8810048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Phenobarbital 9.6616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.6612621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D006561 Herpes Simplex resveratrol 4.5716876885
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16354765 15340226 16959395 18606429
MESH:D006937 Hypercholesterolemia resveratrol 4.2917188708
MESH:D006949 Hyperlipidemias resveratrol 4.3316873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.5717488730
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 5.0117600658
MESH:D007249 Inflammation resveratrol 5.5016366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5012200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.9916624496
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.7516087638
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.4621137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 11.4619812893 19073162 21047994 8742319 15975961 19482888
MESH:D008113 Liver Neoplasms resveratrol 11.4619812893 19321006 20405173 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.4616984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.332563599 18308698 6150874 1399818 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2518520028 18816296 17053015 20464547 20869020 18569708 6695378 20135361 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2511884234 19555203
MESH:D016393 Lymphoma, B-Cell resveratrol 4.6017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.1014749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.6415688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.7116891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.718985016 11606380
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008545 Melanoma resveratrol 2.4017992120
MESH:D008659 Metabolic Diseases resveratrol 4.6617112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma resveratrol 3.6616267019 17935668 17049120 14749477 16490592 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.2717962980
MESH:D009203 Myocardial Infarction resveratrol 3.1217188708 16456233 16525036 17125593 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 9.7617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.7612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009205 Myocarditis resveratrol 5.1617322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009374 Neoplasms, Experimental resveratrol 4.368985016
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 10.5811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5814600291
MESH:D019636 Neurodegenerative Diseases resveratrol 4.0417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.7017929310
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.5617513867
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.9511118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms resveratrol 2.5216731767 17675339 17718901 17804756 15767336 17636462
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D051436 Renal Insufficiency, Chronic resveratrol 6.0316325855
MESH:D015427 Reperfusion Injury resveratrol 3.3916314181 17520802 16317513 17058453 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures Phenobarbital 2.8711442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 14.5219755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 14.528985016 15837718
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.528532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.5216192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.7516321402
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014062 Tongue Neoplasms resveratrol 4.4816227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2617053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.3717473185
MESH:D014594 Uterine Neoplasms resveratrol 4.4617044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.6617488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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