AutismKB 2.0

Annotation Detail for KIF1A


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Basic Information Top
Gene Symbol:KIF1A ( ATSV,C2orf20,DKFZp686I2094,FLJ30229,HUNC-104,MGC133285,MGC133286,UNC104 )
Gene Full Name: kinesin family member 1A
Band: 2q37.3
Quick LinksEntrez ID:547; OMIM: 601255; Uniprot ID:KIF1A_HUMAN; ENSEMBL ID: ENSG00000130294; HGNC ID: 888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000244 Adenosine Diphosphate KIF1A protein binds to Adenosine Diphosphate analogaffects binding 15286375
D000266 Adenylyl Imidodiphosphate KIF1A protein binds to Adenylyl Imidodiphosphateaffects binding 15286375
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KIF1A mRNAaffects expression 17484886
D004958 Estradiol Estradiol results in decreased expression of KIF1A mRNAdecreases expression 20068009
C030667 methylazoxymethanol methylazoxymethanol results in increased expression of KIF1A mRNAincreases expression 17107856
D009151 Mustard Gas Mustard Gas results in decreased expression of KIF1A mRNAdecreases expression 15674843
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of KIF1A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of KIF1A mRNAincreases expression 19482888
D012402 Rotenone Rotenone results in increased expression of KIF1A mRNAincreases expression 19013527
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3117620307
MESH:D001249 Asthma Mustard Gas 2.7710378619
MESH:D001768 Blister Mustard Gas 5.5019167455
MESH:D001943 Breast Neoplasms Estradiol 2.1217018787 12948864 19861407 17289903 14630087 18497071 16675129 17261762
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.3510378619 17687719
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0818705752 15700767 16097048 15721981 16192424 15673190 16011737 16227642 3786805 10355542 16124888 16050911
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7717173139 20935162 6705139 1701930 20007298
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0915027814 2869522 6623471 19085960 10092053 21278145 6884620 9327722 15998439 3786805 11566570 15968718 7179309 7120509 19336974 4309450 3732212 7440962 17522070 10915739 16227642 16177239
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema Mustard Gas 3.5511428647 9260866 11402378 11428631
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 18566989 11473722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004890 Erythema Mustard Gas 5.509357497
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4116045604 12631006 16239168 17595544 61145 12795759 19224547 15959796
MESH:D005355 Fibrosis Carbon Tetrachloride 3.7618705752
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.7916109766
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Mustard Gas 2.899357497 8975870 11428647 11428620 11428631 9260866 11402378 17524151 16001271
MESH:D007333 Insulin Resistance Estradiol 3.1116627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7115618244
MESH:D007680 Kidney Neoplasms Estradiol 3.1815610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0416221502 17157831 16943688 16239168 11408273 17174718 17334410 21278145 11903743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5018277467 18418968 18395914 13678700 12389079 12609069 18472094 18187930 18006644 14724832 15931870 16116963 16248980 16033810 12445418 11481614 18210741 18205269 17698563 10355542 14716496 18481824 17922224 17944888 16638106 18339082 16015684 18376398 12632514 18166357 17805973 18429990 12666154 12445421 15925388 15650968 14512876 17900296 17823541 18395095 18412020 17766677 15338365 15052691 14748882 15123356 16136751 12958196 15673190 16027843 17761835 15959796 15370692 15362042 18472332 15996030 17869086 17631135 15730626 12667390 17481882 18705752 12649538 17640975 18054572 16192424 14620537 17721639 17708605 14716833 12898905 12741479 17557913 15057751 15818738 16011737 12546737 12632512 18420326 17714472 18279442 18251166 15876570 12586293 18263696 15893842 17976157 16097048 20821823 17525996 18317297 17565644 18156304
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5014716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2716246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Phenobarbital 4.2719363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9214706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.8719294768
MESH:D008113 Liver Neoplasms Phenobarbital 4.8719812893 19482888 15975961 19073162 8742319 21047994
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.4515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.456150874 17172636 18308698 1399818 2563599
MESH:D008171 Lung Diseases Mustard Gas 3.6018161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009410 Nerve Degeneration Rotenone 4.0615790535 18619942 17356569
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D009503 Neutropenia Mustard Gas 4.2316761898 7688884
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D010300 Parkinson Disease Rotenone 3.0511445065 16140633 15451049 18191903 11535288 18619942 19114014 16412576 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015927086 15574749 15795934 18197244
MESH:D011041 Poisoning Mustard Gas 4.0615727166
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011537 Pruritus Mustard Gas 4.4318058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0017894541 17266442 17620002 10334151 17720292
MESH:D012640 Seizures Phenobarbital 2.843137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012871 Skin Diseases Mustard Gas 2.7616961503 12880345 15451306
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.231399818
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03431 - Adenosine-5'-Diphosphate
DB03909 - Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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