AutismKB 2.0

Annotation Detail for PDP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDP1 ( FLJ32517,FLJ56179,MGC119646,PDH,PDP,PDPC,PPM2C )
Gene Full Name: pyruvate dehyrogenase phosphatase catalytic subunit 1
Band: 8q22.1
Quick LinksEntrez ID:54704; OMIM: 605993; Uniprot ID:PDP1_HUMAN; ENSEMBL ID: ENSG00000164951; HGNC ID: 9279
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
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Related Diseases/Disorders Top
Desease IDDesease Name
H00072Pyruvate dehydrogenase complex deficiency
Inherited disorders of carbohydrate metabolism
Genetic disorders
No data
No data
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Desease Name
Pyruvate dehydrogenase phosphatase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDP1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PDP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDP1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of PDP1 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PDP1 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDP1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PDP1 mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDP1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of PDP1 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of PDP1 mRNAdecreases expression 16002434
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of PDP1 mRNAincreases expression 15954086
D007213 Indomethacin Indomethacin results in decreased expression of PDP1 mRNAdecreases expression 16984733
D008701 Methapyrilene Methapyrilene results in increased expression of PDP1 mRNAincreases expression 16393664
D011374 Progesterone Progesterone results in decreased expression of PDP1 mRNAdecreases expression 18037150
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of PDP1 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of PDP1 mRNAaffects cotreatment|increases expression 19059307
C004648 testosterone enanthate testosterone enanthate affects the expression of PDP1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDP1 mRNAincreases expression 20106945
D015032 Zinc Zinc results in increased expression of PDP1 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PDP1 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.4218287403
MESH:D000138 Acidosis Zinc Sulfate 10.427265320
MESH:D000169 Acrodermatitis Zinc 5.3417190629 16889938 17202136
MESH:D000230 Adenocarcinoma Indomethacin 2.7716537180
MESH:D000236 Adenoma Ethylnitrosourea 7.126695378
MESH:D000236 Adenoma Indomethacin 7.1211497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3216835633
MESH:D000419 Albuminuria Raloxifene 4.5317308373 17451421
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3217225004
MESH:D000544 Alzheimer Disease Indomethacin 6.7017627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 6.7015800139
MESH:D000544 Alzheimer Disease Zinc 6.7016325427 16410023 17119284 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8416916123
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D000860 Anoxia Zinc Sulfate 4.967265320
MESH:D001014 Aortic Aneurysm Indomethacin 4.7810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8110388637
MESH:D018771 Arthralgia Indomethacin 5.112160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8111248219
MESH:D001249 Asthma Zinc 2.9317085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001477 Bartter Syndrome Indomethacin 4.9210684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.8214991843
MESH:D001929 Brain Edema Indomethacin 4.9711481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2817868700
MESH:D001930 Brain Injuries Progesterone 18.1015665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 18.1016580743
MESH:D001930 Brain Injuries Zinc 18.1017109824
MESH:D002545 Brain Ischemia Indomethacin 4.3612524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.2318412241 16436596 16651633 16357521 15144691
MESH:D001943 Breast Neoplasms Calcitriol 2.9311237771
MESH:D001943 Breast Neoplasms Indomethacin 2.9317401462
MESH:D001943 Breast Neoplasms Progesterone 2.9315562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 2.9317595753 16912660 17952589 17440819 15775269 15758505 17261762 15572757 16837676 17893378 17049068 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 2.9319103187 18821012 19289846 17893378 17261762 20135344 19288272 18351453 19059307 19221464 21152245 20065188 16873071 18855134 19410462 19115204 20390343 19155303 20005174 18997820 17440819 11161223 21138602 19011961 19084267 19244106 19487384 16818667 19200415 16202921 17049068 20544844 18425577 19189212 20859285 19189210 18984771 19142967 17242785 18629630 15668708 18815881 16273361 19066611 15565566
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D002056 Burns Indomethacin 4.6410459503
MESH:D002100 Cachexia Indomethacin 4.9415625704 15141370 16537180 11239499
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7216097048 16227642 16192424 18705752 16050911 15673190 15721981 3786805 15700767 10355542 16011737 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.763084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7618788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.7616391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7616924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2911352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.3417341418
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.6211237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.6215482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.6216543248
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.3017572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.3017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 7.4815775269
MESH:D002318 Cardiovascular Diseases Zinc 7.4816936243
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0012371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 11.0016003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.9317160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002764 Cholecystitis Indomethacin 5.1111181007
MESH:D002779 Cholestasis Cyclosporine 2.8719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 12621046 15340226 8697196 16354765
MESH:D003072 Cognition Disorders Raloxifene 4.5515800139
MESH:D003110 Colonic Neoplasms Indomethacin 2.5815963497 15637740 15936596 11260862 15625704 15786552
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3517054584 18059344 11197048 12606626
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.6617302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6510048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.6519302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1017474826
MESH:D003920 Diabetes Mellitus Zinc 4.1516479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.8417451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.8419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4317187935
MESH:D003967 Diarrhea Indomethacin 3.737907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.7819739265 12705907 11739529 17906064 16393943 16109766 16781746 18071297 19370779 19164858 12153990 16227642 19416960 15968718 14725611 19085960 2444490 12594235 18713872 11421492 12540782 12958197 19923254 14986274 10663392 19420014 14550746 11287661 11461765 16177239 17562736 11834606 16485898 16081117 10774834 15619225 11529661 10915739 12392966 17522070 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.782869522 19336974 16177239 3786805 21278145 7120509 4309450 15998439 16227642 10092053 17522070 11566570 10915739 6884620 7179309 6623471 15027814 9327722 7440962 15968718 19085960 3732212
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0918446180 16133044 12774134 17190690 18043480 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 4.0711535926 17351913 17151854 11595431 11991626 17202747 17329845 11595415 16699067 17045617 10671773
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.9318357618
MESH:D004487 Edema Indomethacin 11.217907874 8985016 16100529 10653021 8273558 7990266 19703484
MESH:D004487 Edema Raloxifene 11.2115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.2112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 21.4515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 21.4517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 21.4515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0020544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Indomethacin 14.9615652904
MESH:D004715 Endometriosis Progesterone 14.9616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.9610568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.4418509659
MESH:D004751 Enteritis Indomethacin 4.6916328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9217980183
MESH:D004802 Eosinophilia Indomethacin 3.9911298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2920426865
MESH:D004938 Esophageal Neoplasms Indomethacin 7.2911005569
MESH:D004938 Esophageal Neoplasms Zinc 7.2916543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.2916239168 12631006 15959796 19224547 61145 12795759 16045604 17595544
MESH:D005234 Fatty Liver Cyclosporine 18.2919224547
MESH:D005234 Fatty Liver Raloxifene 18.2917473493
MESH:D005234 Fatty Liver Tamoxifen 18.2914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005334 Fever Indomethacin 4.0611852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005354 Fibrosarcoma Indomethacin 4.8310962813
MESH:D005355 Fibrosis Carbon Tetrachloride 20.6518705752
MESH:D005355 Fibrosis Cyclosporine 20.6512639820 12168785
MESH:D005355 Fibrosis Indomethacin 20.6517994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.6520067830
MESH:D005499 Folliculitis Indomethacin 5.1111298111
MESH:D005756 Gastritis Acetaminophen 18.7616983495
MESH:D005756 Gastritis Indomethacin 18.7615046732
MESH:D005756 Gastritis Zinc 18.7617241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Ethylnitrosourea 7.4816436596
MESH:D005909 Glioblastoma Indomethacin 7.4812870263
MESH:D005910 Glioma Ethylnitrosourea 6.3916357521 16651633 18412241
MESH:D005910 Glioma Indomethacin 6.3918371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006073 Gout Indomethacin 5.2911248219
MESH:D006130 Growth Disorders Zinc 3.9217217573
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7015482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3010048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4911110106
MESH:D006333 Heart Failure Zinc 3.5717162251
MESH:D006335 Heart Injuries Zinc 5.7117074742
MESH:D016481 Helicobacter Infections Zinc 4.4717241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5115633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6215135802
MESH:D006527 Hepatolenticular Degeneration Zinc 11.1117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.1117063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8316120746 15340226 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6917440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 16354765 18606429 8697196 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.6516870215
MESH:D006930 Hyperalgesia Indomethacin 7.6512727271
MESH:D034321 Hyperamylasemia Indomethacin 5.6617883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006940 Hyperemia Indomethacin 4.9412524144
MESH:D006949 Hyperlipidemias Indomethacin 4.1017546600
MESH:D006973 Hypertension Cyclosporine 8.4310903974
MESH:D006973 Hypertension Raloxifene 8.4315787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D007022 Hypotension Zinc Sulfate 4.417265320
MESH:D007077 Ileal Diseases Indomethacin 4.9710574470 18306037
MESH:D007079 Ileitis Indomethacin 5.2916133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.3216133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3415869954
MESH:D007249 Inflammation Indomethacin 11.7012568917 7812673 3291741
MESH:D007249 Inflammation Progesterone 11.7015869954
MESH:D007249 Inflammation Tamoxifen 11.7019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.7012200463 12878042
MESH:D007410 Intestinal Diseases Indomethacin 4.2611713966 15831440 17994277 11855677 15610444 11686837 10210152 18236018 17329856
MESH:D019586 Intracranial Hypertension Indomethacin 5.3215241188
MESH:D007511 Ischemia Zinc 4.5716584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007579 Jejunal Diseases Indomethacin 4.9710574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 14.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.168314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 14.1617190690
MESH:D007674 Kidney Diseases Zinc 14.1616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.3316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.3312371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 17.3317379185
MESH:D007680 Kidney Neoplasms Tamoxifen 17.3318625569
MESH:D007889 Leiomyoma Raloxifene 4.4316973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 8.6110320625 12228301 11703811
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 8.6115237267
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.8716572323 15631656 10785260
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6218360721
MESH:D007964 Leukocytosis Indomethacin 5.3216537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6617980183
MESH:D008064 Lipidoses Tamoxifen 3.1115342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6611479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7716239168 16943688 17174718 11408273 21278145 11903743 17157831 17334410 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.9018429990 17823541 18481824 18376398 18166357 12632512 14716833 12898905 17869086 16192424 16011737 12666154 20821823 18251166 15959796 17805973 12609069 15730626 11481614 18006644 16638106 14512876 17900296 12445418 12586293 14620537 18395095 12546737 17481882 17708605 15052691 17766677 14724832 17761835 18277467 15370692 12958196 15338365 10355542 15931870 15996030 13678700 17922224 17714472 17565644 12389079 15893842 18395914 14748882 17698563 17721639 17557913 15362042 17631135 18420326 12445421 18339082 18187930 16097048 18412020 16116963 15673190 16027843 18418968 18705752 16015684 15057751 18156304 18472094 15925388 16136751 15876570 12649538 14716496 17944888 12632514 18317297 18054572 18205269 16248980 18279442 12667390 16033810 17525996 15123356 18210741 12741479 17640975 18472332 15818738 18263696 17976157 15650968
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.9018194892
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.9018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9012878042
MESH:D008107 Liver Diseases Acetaminophen 3.8419784758 11587558 16611625 19460945 12969438 19014921 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.8417285989 15830285 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 10.5319294768
MESH:D008113 Liver Neoplasms Methapyrilene 10.5315890375
MESH:D008113 Liver Neoplasms Tamoxifen 10.5316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.6212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6212151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.9617365036
MESH:D008175 Lung Neoplasms Ethylnitrosourea 4.846695378 16271038 16019985 17703301
MESH:D008175 Lung Neoplasms Indomethacin 4.8411053908 11497255 16537180
MESH:D008175 Lung Neoplasms Tamoxifen 4.8418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8411884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.8915790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.9815375218
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 13.9910767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.9917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 13.9911731420 16827153 14580682 19196723 19196722
MESH:D008325 Mammary Neoplasms, Experimental Zinc 13.9912773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008545 Melanoma Tamoxifen 1.8719393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008579 Meningioma Ethylnitrosourea 5.9317943659
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1616966607 16166281 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008881 Migraine Disorders Indomethacin 3.6311903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5015863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.9412636206
MESH:D009101 Multiple Myeloma Raloxifene 3.3916497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009232 Myxoma Raloxifene 5.5016343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8018551238
MESH:D009362 Neoplasm Metastasis Indomethacin 5.8611239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.8619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 9.3416707424
MESH:D009374 Neoplasms, Experimental Indomethacin 9.3415625704 10663608
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.3517160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2218514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 8.2212349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.116374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.3716049721 12819281
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.9317160924
MESH:D010003 Osteoarthritis Indomethacin 3.637009135
MESH:D010024 Osteoporosis Raloxifene 3.3517882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1615579764 17893378 17823083 15758505
MESH:D010051 Ovarian Neoplasms Progesterone 2.5017393432 16525653
MESH:D010146 Pain Acetaminophen 6.6116870215
MESH:D010146 Pain Indomethacin 6.6117627676 3291741 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 4.6212538197 18702446
MESH:D010195 Pancreatitis Indomethacin 3.8615028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0612349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0911148446
MESH:D010518 Periodontitis Indomethacin 4.8617225004
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011225 Pre-Eclampsia Zinc 4.1217114810
MESH:D047928 Premature Birth Indomethacin 5.0617000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311222880 11896295 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1415754350 16289102 18247401 16644109 12479363
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1415731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1415067354
MESH:D011471 Prostatic Neoplasms Zinc 2.1416517595 16700911 16606632 12429649
MESH:D011507 Proteinuria Indomethacin 4.1011849393
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0015814490 17975199 17365031 17322281
MESH:D011693 Purpura Raloxifene 5.5015770314
MESH:C536258 Pyruvate dehydrogenase phosphatase deficiency marker/mechanism
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012162 Retinal Degeneration Zinc 4.0716584753
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8318045962
MESH:D012640 Seizures 2,4-dinitrotoluene 2.4918551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.498532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4916192470
MESH:D013088 Spermatocele Tamoxifen 4.2416709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.6715862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.6719457130
MESH:D013272 Stomach Diseases Indomethacin 4.3617207306 16184426 15038085 16280098 10486359 17160473 10215738 18209964 15472012 16113693 17638125 18545984 10192188
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.5215104355 11145282 11906479 18193104 17627676 16150113 10423059 18299717 10878458 18726076 12077510 17654042 18543354 11595431 1323529 10750652 18181030 14567935 18431645 16252198 16397915 12787963 16631530 12498302 17895592 11595415 16755016 18087811 18209962 16169175 17135157 12500499 15138204 16934674 17918041 17657623 17977527 11729361 15255614 12467913 11523592 18237397
MESH:D020521 Stroke Raloxifene 3.7716837676
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.1015790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.5314736730 11352223 18791128
MESH:D013978 Tibial Fractures Raloxifene 5.1519048282
MESH:D014062 Tongue Neoplasms Zinc 4.3416543248
MESH:D014456 Ulcer Indomethacin 4.8317380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2116049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.2117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.218653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2510091137
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.1516837676
MESH:D014839 Vomiting Indomethacin 4.6911897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
Pathway ID Pathway Name
KEGG:04711 Circadian rhythm - fly
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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