AutismKB 2.0

Annotation Detail for OTUD4


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Basic Information Top
Gene Symbol:OTUD4 ( DKFZp434I0721,DUBA6,HIN1,HSHIN1,KIAA1046 )
Gene Full Name: OTU domain containing 4
Band: 4q31.21
Quick LinksEntrez ID:54726; OMIM: 611744; Uniprot ID:OTUD4_HUMAN; ENSEMBL ID: ENSG00000164164; HGNC ID: 24949
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of OTUD4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of OTUD4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of OTUD4 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OTUD4 mRNAdecreases expression 19150397
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in decreased expression of OTUD4 mRNAdecreases expression 17982090
C025643 vinclozolin vinclozolin results in decreased expression of OTUD4 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.356135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.9616782535 18200517 16474422 17936198 11698051 16867261 16804969 18023891 17991707
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.5317276891
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6211743745 17906064 18071297 17522070 12540782 16109766 14550746 11461765 11739529 12958197 16485898 14725611 19370779 19164858 12705907 19085960 2444490 15968718 17562736 14986274 10663392 16177239 11287661 19739265 12392966 11421492 12153990 19420014 18713872 15619225 19923254 16781746 16393943 16081117 11529661 11834606 10774834 12594235 10915739 16227642 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 4.7717994277
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.6818200517
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 5.0217994277
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 16611625 19014921 12587719 19460945 11587558 12969438 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.247678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876786 2876784 6135515
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.947678174 18551238
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.5517698068
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3616049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142671216
    • Releated gene ID Related gene Name
    PA142671216OTUD4
    No data
    No data
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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