AutismKB 2.0

Annotation Detail for MPHOSPH8


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Basic Information Top
Gene Symbol:MPHOSPH8 ( FLJ35237,HSMPP8,TWA3,mpp8 )
Gene Full Name: M-phase phosphoprotein 8
Band: 13q12.11
Quick LinksEntrez ID:54737; OMIM: 611626; Uniprot ID:MPP8_HUMAN; ENSEMBL ID: ENSG00000196199; HGNC ID: 29810
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MPHOSPH8 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MPHOSPH8 mRNAdecreases expression 15336504
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNAaffects cotreatment|increases expression 16996129
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MPHOSPH8 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in decreased expression of MPHOSPH8 mRNAdecreases expression 19013527
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury zoledronic acid 4.7919715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.9420200999
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001859 Bone Neoplasms zoledronic acid 5.3115867366 11697798 16778634 16121404 17312309 19442620
MESH:D001862 Bone Resorption zoledronic acid 5.0311869084 18496637 16769263 8053405 15845617 18404659
MESH:D001943 Breast Neoplasms zoledronic acid 3.2718695136 16096432
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.6319233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.9718507039
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003327 Coronary Disease fluvastatin 4.9916142594
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005264 Femoral Fractures zoledronic acid 6.2916234978
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 18467677 16221962 19772884
MESH:D006930 Hyperalgesia zoledronic acid 4.5016769263
MESH:D006934 Hypercalcemia zoledronic acid 5.3718089816 19622757
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006996 Hypocalcemia zoledronic acid 6.7112669777
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 5.0918089816
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 20007298 16377806
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 3.9117312309
MESH:D008654 Mesothelioma zoledronic acid 3.8516675582
MESH:D009101 Multiple Myeloma fluvastatin 8.9016996129
MESH:D009101 Multiple Myeloma zoledronic acid 8.9018089719 16996129 19621390
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009362 Neoplasm Metastasis zoledronic acid 3.7419139120 15867366 17312309
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009410 Nerve Degeneration Rotenone 4.1218619942 15790535 17356569
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010014 Osteolysis zoledronic acid 5.8315867366
MESH:D010024 Osteoporosis zoledronic acid 4.2117882678
MESH:D010146 Pain zoledronic acid 4.2016475674
MESH:D010300 Parkinson Disease Rotenone 3.0718191903 19232380 16140633 11445065 16412576 11535288 18619942 19114014 15451049
MESH:D020734 Parkinsonian Disorders Rotenone 4.3818197244 15795934 15574749 15927086
MESH:D011471 Prostatic Neoplasms zoledronic acid 4.1912438248 19103299
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012512 Sarcoma, Ewing's zoledronic acid 5.3116121404
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.818532709
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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