AutismKB 2.0

Annotation Detail for RNF111


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Basic Information Top
Gene Symbol:RNF111 ( ARK,DKFZp313E0731,DKFZp686H1966,DKFZp761D081,FLJ38008 )
Gene Full Name: ring finger protein 111
Band: 15q22.1-q22.2
Quick LinksEntrez ID:54778; OMIM: 605840; Uniprot ID:RN111_HUMAN; ENSEMBL ID: ENSG00000157450; HGNC ID: 17384
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
200195TGF-beta receptor signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RNF111 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RNF111 mRNAdecreases expression 19150397
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RNF111 mRNAaffects binding|increases activity|increases expression 19710929
D012643 Selenium Selenium results in decreased expression of RNF111 mRNAdecreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of RNF111 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2115131321
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1516080930
MESH:D006333 Heart Failure pirinixic acid 7.6220558911
MESH:D006333 Heart Failure Selenium 7.6217162251
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19176532 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007251 Influenza, Human Selenium 13.0916624496
MESH:D007251 Influenza, Human Vitamin E 13.0916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Vitamin E 2.9812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.2816705839
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4616169303
MESH:D008113 Liver Neoplasms pirinixic acid 1.9216377806 20007298 15890375
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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