AutismKB 2.0

Annotation Detail for TRIT1


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Basic Information Top
Gene Symbol:TRIT1 ( FLJ20061,IPT,MGC149242,MGC149243,MOD5 )
Gene Full Name: tRNA isopentenyltransferase 1
Band: 1p34.2
Quick LinksEntrez ID:54802; OMIM: NA; Uniprot ID:MOD5_HUMAN; ENSEMBL ID: ENSG00000043514; HGNC ID: 20286
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TRIT1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TRIT1 mRNAaffects expression 21346803
D001241 Aspirin Aspirin results in increased expression of TRIT1 mRNAincreases expression 11906190
C006780 bisphenol A bisphenol A results in decreased expression of TRIT1 mRNAdecreases expression 20678512
C006253 pirinixic acid pirinixic acid results in increased expression of TRIT1 mRNAincreases expression 18301758
D012643 Selenium Selenium results in decreased expression of TRIT1 mRNAdecreases expression 19244175
D013467 Sulindac Sulindac results in decreased expression of TRIT1 mRNAdecreases expression 11906190
D014810 Vitamin E Vitamin E results in decreased expression of TRIT1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.8714745880
MESH:D058186 Acute Kidney Injury Sulindac 4.567897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Sulindac 3.1611910360
MESH:D000236 Adenoma Sulindac 3.9110223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.8311535846 17611924 19003578 12394442 11874996 15623613 16460482
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9012372130 20485159
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001913 Bowen's Disease Sulindac 5.7311207687
MESH:D001932 Brain Neoplasms Aspirin 4.6415481559
MESH:D001943 Breast Neoplasms Aspirin 2.1915161893
MESH:D001943 Breast Neoplasms bisphenol A 2.1917123778
MESH:D001943 Breast Neoplasms Sulindac 2.1916642371
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2416050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0516705839
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms Aspirin 4.4812411196
MESH:D003110 Colonic Neoplasms Sulindac 4.4812902858 12458338
MESH:D015179 Colorectal Neoplasms Aspirin 3.1717047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1710666051 11197048 18059344 11076880
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003930 Diabetic Retinopathy Sulindac 5.4612861449 17621415
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6115131321
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Aspirin 7.9117259670
MESH:D004487 Edema pirinixic acid 7.9112083418
MESH:D004715 Endometriosis Sulindac 4.7015652904
MESH:D004938 Esophageal Neoplasms Sulindac 3.1812235107
MESH:D005234 Fatty Liver pirinixic acid 3.0119236843 20131406
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.8214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.4719069698
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2911910360
MESH:D005909 Glioblastoma Aspirin 4.1012870263
MESH:D006261 Headache Aspirin 5.3415240983
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1016080930
MESH:D006333 Heart Failure pirinixic acid 7.4120558911
MESH:D006333 Heart Failure Selenium 7.4117162251
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D012001 Hyperacusis Aspirin 6.1415240983
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007249 Inflammation Sulindac 3.413291741
MESH:D007251 Influenza, Human Selenium 12.2516624496
MESH:D007251 Influenza, Human Vitamin E 12.2516624496
MESH:D007333 Insulin Resistance bisphenol A 7.8116393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8116306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.8612628509 10213222 10223192 12584176 12663524 12351151
MESH:D007417 Intestinal Polyps Sulindac 5.2511245490 12394442
MESH:D007674 Kidney Diseases Vitamin E 2.9312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0416705839
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3612468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4416169303
MESH:D008107 Liver Diseases Sulindac 3.0716867024 14986274
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.677678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6715890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876784 2876786 6135515
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Sulindac 2.9019359593 15713900
MESH:D008175 Lung Neoplasms Vitamin E 2.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008881 Migraine Disorders Aspirin 4.2315240983
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction Aspirin 6.2212692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009325 Nausea Aspirin 5.5915240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.507678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009421 Nervous System Malformations bisphenol A 4.2516427766 11399458
MESH:D019636 Neurodegenerative Diseases Sulindac 4.4717266991 16850258
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010003 Osteoarthritis Aspirin 4.197009135
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010146 Pain Aspirin 8.136995502 6363464
MESH:D010146 Pain Sulindac 8.133291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4211504793 16820089
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8811156591
MESH:D020795 Photophobia Aspirin 6.1415240983
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2910548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2916740699
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012220 Rhinitis Aspirin 4.6012372130
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3918551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5712269725
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D020521 Stroke Aspirin 9.5616403987
MESH:D020521 Stroke Vitamin E 9.5616517955
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216045194 16684133
MESH:D013927 Thrombosis Aspirin 4.7317672075
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Aspirin 4.7010982225 20485159
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D014594 Uterine Neoplasms Sulindac 4.8818645019
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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