AutismKB 2.0

Annotation Detail for CNNM2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CNNM2 ( ACDP2 )
Gene Full Name: cyclin M2
Band: 10q24.32
Quick LinksEntrez ID:54805; OMIM: 607803; Uniprot ID:CNNM2_HUMAN; ENSEMBL ID: ENSG00000148842; HGNC ID: 103
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
Parkinson's disease
CARDIOVASCULAR
systolic blood pressure
NEUROLOGICAL
Desease Name
Intracranial aneurysm
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of CNNM2 mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in increased expression of CNNM2 mRNAincreases expression 20458559
D001374 Azacitidine Azacitidine results in decreased expression of CNNM2 mRNAdecreases expression 19194470
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CNNM2 mRNAdecreases expression 20018196
D016572 Cyclosporine Cyclosporine results in increased expression of CNNM2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CNNM2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNNM2 mRNAaffects cotreatment|increases expression 17942748
C051890 irinotecan irinotecan analog results in increased expression of CNNM2 mRNAincreases expression 18927307
D037742 Nanotubes, Carbon Nanotubes, Carbon results in increased expression of CNNM2 mRNAincreases expression 15585362
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CNNM2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 11752688 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4419825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0518651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.6219483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 16.6216206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.6212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9714691202 15073043 16217749 15553829 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9519225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0112371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 8.2819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2815861022 17333356 16919318 17110522 17681005 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1816354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms irinotecan 2.6217725105 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.6920501625
MESH:D015179 Colorectal Neoplasms Azacitidine 3.6919934284
MESH:D015179 Colorectal Neoplasms irinotecan 3.6916303861 16391804 17454858 17159606 18509181 18259882 15273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 10048152 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0215265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6120426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6112903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Amiodarone 20.5614986274
MESH:D005234 Fatty Liver arsenic trioxide 20.5615073043
MESH:D005234 Fatty Liver Cyclosporine 20.5619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.5615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 9.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Amiodarone 9.4115265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006937 Hypercholesterolemia Amiodarone 4.088137927 9751232
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.7718020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia arsenic trioxide 6.9915070760
MESH:D007938 Leukemia Azacitidine 6.9919148494
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.5119077051
MESH:D007951 Leukemia, Myeloid Azacitidine 10.5119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.3317050201 16467208 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.3317596541 18720364
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.4119299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3419035177 12712474 17217047 17649720 16112521 17712046 11468182 15213294 15622746 16891316 16966277 19642359 12018890 9834237 19075265 17107899 19225113 16823087 15748426 12679006 16330433 17869043 16331271 11161223 15336539
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008064 Lipidoses Amiodarone 3.6515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008133 Long QT Syndrome Amiodarone 8.7215350150 11989578 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 8.7215213294
MESH:D008171 Lung Diseases Amiodarone 3.5012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6211798837 19825857
MESH:D008175 Lung Neoplasms Azacitidine 3.6221224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6219555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009006 Monosomy Azacitidine 6.4019299654
MESH:D052016 Mucositis irinotecan 5.2917159606
MESH:D009101 Multiple Myeloma arsenic trioxide 8.0819549372 15949261 11468182 14977855 19417148
MESH:D009101 Multiple Myeloma Azacitidine 8.0818443271 19549372
MESH:D009181 Mycoses Amiodarone 5.2212754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.0916882451 16105982
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.0917596541 19805378 17611569 18720364
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009362 Neoplasm Metastasis irinotecan 3.2418259882
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D009447 Neuroblastoma irinotecan 3.578761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.018761367
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 19769630 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.5619131511
MESH:D011471 Prostatic Neoplasms Azacitidine 3.5618324645
MESH:D011537 Pruritus Ethinyl Estradiol 3.6016919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9211597910 12832656 12490602
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.7017007042
MESH:D013274 Stomach Neoplasms irinotecan 2.7015723263
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Amiodarone 13.1419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.1412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D013971 Thyrotoxicosis Amiodarone 5.1219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 11.2311989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 11.2315213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5511780464 20435036 12973940 12845720
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved