AutismKB 2.0

Annotation Detail for DYM


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Basic Information Top
Gene Symbol:DYM ( DMC,FLJ20071,FLJ90130,SMC )
Gene Full Name: dymeclin
Band: 18q21.1
Quick LinksEntrez ID:54808; OMIM: 607461; Uniprot ID:DYM_HUMAN; ENSEMBL ID: ENSG00000141627; HGNC ID: 21317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
Desease Name
Smith-McCort dysplasia
Dyggve-Melchior-Clausen disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DYM mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DYM proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DYM mRNAdecreases expression 20106945
20064835
D016572 Cyclosporine Cyclosporine results in increased expression of DYM mRNAincreases expression 20106945
D006918 Hydroxyurea Hydroxyurea results in increased mutagenesis of DYM geneincreases mutagenesis 16868089
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of DYM geneincreases mutagenesis 16868089
D009151 Mustard Gas Mustard Gas affects the expression of DYM mRNAaffects expression 15651846
D012643 Selenium Selenium results in decreased expression of DYM mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of DYM mRNAaffects binding|increases expression 16214954
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DYM mRNAincreases expression 18796159
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1314514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.8120127859 20464547
MESH:D000230 Adenocarcinoma Methylnitrosourea 4.8115113128 15688392
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001249 Asthma Mustard Gas 2.7610378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001768 Blister Mustard Gas 5.4419167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Methylnitrosourea 1.9216253758 11306469 14633655
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2917687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 2.9712907637 12619106 21507988
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.9310977129
MESH:D002386 Cataract Methylnitrosourea 7.9312484553
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.4112371664
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 7.412727394 7505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815668235 16354765 8697196 12621046 15340226
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4510663392 19370779 14725611 15619225 19416960 10774834 18713872 19923254 16781746 14550746 12705907 2444490 11461765 12540782 18071297 12153990 10915739 11529661 17522070 16393943 19739265 11739529 11421492 12392966 12958197 16485898 19085960 11743745 15968718 17562736 16109766 11834606 16227642 19420014 12594235 16081117 14986274 11287661 17906064 19164858 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C535726 Dyggve-Melchior-Clausen syndrome marker/mechanism
MESH:D004487 Edema Mustard Gas 7.5311402378 11428647 11428631 9260866
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004890 Erythema Mustard Gas 5.449357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 3.0619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.5211555667
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005910 Glioma Methylnitrosourea 3.639825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7710048152 11294989
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 16959395 15340226 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D007248 Infertility, Male Methylnitrosourea 3.927193160
MESH:D007249 Inflammation Mustard Gas 5.379357497 11428631 17524151 11402378 11428620 9260866 8975870 16001271 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3712878042 12200463
MESH:D007251 Influenza, Human Selenium 4.5116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.168314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.2216532439
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3515526292
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 16611625 19784758 11587558 19014921 12587719 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.782125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7820195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.218603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.7216080182
MESH:D008171 Lung Diseases Mustard Gas 3.5818702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.8214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.8218520028 20869020 18569708 20064080 18816296 17053015 20464547 6695378 20135361
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.8218062963
MESH:D008175 Lung Neoplasms Mustard Gas 6.823148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8219555203 11884234
MESH:D008223 Lymphoma Methylnitrosourea 4.1511418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.9914633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.8215688392 15113128 17020996 11807958 16944150 10767621 16619500 11751437 14633655 15313902 16827153 17131329 12931682 14999141 16051031 19196723 10838139
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.8215318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6211141357
MESH:D009369 Neoplasms Methylnitrosourea 5.6215533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.7312696579
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009442 Neurilemmoma Methylnitrosourea 5.7711555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009503 Neutropenia Mustard Gas 4.197688884 16761898
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4216965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011041 Poisoning Mustard Gas 4.0215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.4417292933
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.4415682402 12376480
MESH:D011537 Pruritus Mustard Gas 4.3818058305
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9917894541 10334151 17266442 17720292 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.5618172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.7711555667
MESH:D012871 Skin Diseases Mustard Gas 2.7612880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
OMIM:607326 SMITH-MCCORT DYSPLASIA marker/mechanism
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.7220155912 2093021
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7218593901 16257854 15930296
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.5211418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.073078959 7505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2417053015
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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