AutismKB 2.0

Annotation Detail for ERCC6L


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Basic Information Top
Gene Symbol:ERCC6L ( FLJ20105,MGC131695,PICH )
Gene Full Name: excision repair cross-complementing rodent repair deficiency, complementation group 6-like
Band: Xq13.1
Quick LinksEntrez ID:54821; OMIM: 300687; Uniprot ID:ERC6L_HUMAN; ENSEMBL ID: ENSG00000186871; HGNC ID: 20794
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Cell Cycle, Mitotic
DNA Replication
Pathway IDPathway Name
200087PLK1 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ERCC6L proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ERCC6L mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ERCC6L mRNAincreases expression 17484886
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of ERCC6L mRNAincreases expression 18242016
D004958 Estradiol Estradiol results in increased expression of ERCC6L mRNAincreases expression 20106945
D008345 Manganese Manganese results in decreased expression of ERCC6L mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of ERCC6L mRNAdecreases expression 17175027
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of ERCC6L mRNAincreases expression 20713471
D010081 Oxazolone Oxazolone results in increased expression of ERCC6L mRNAincreases expression 18242016
D010100 Oxygen Oxygen deficiency results in decreased expression of ERCC6L mRNAdecreases expression 17175027
C017947 sodium arsenite sodium arsenite results in decreased expression of ERCC6L mRNAdecreases expression 17998272
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of ERCC6L mRNAincreases expression 18242016
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Oxygen 4.6516759491
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D000236 Adenoma Methylcholanthrene 3.566695378 10545420
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0816712894 17306315
MESH:D000756 Anemia, Sideroblastic Manganese 11.4016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.4016910769
MESH:D000860 Anoxia Oxygen 5.2120872349
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.5316210060 19187332 12762349 15590891 6091946 3040596 11742282 15590890 20032816 7684630 12585506 12684321 6091945 18394133 8156442 10797510 15855793 10934080 17015710 16792590 170078 11077013 11467998
MESH:D050197 Atherosclerosis Methylcholanthrene 7.3711922910
MESH:D050197 Atherosclerosis Oxygen 7.3716391483
MESH:D001943 Breast Neoplasms Estradiol 2.1116675129 19861407 12948864 17289903 18497071 17261762 14630087 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.1117474063
MESH:D001943 Breast Neoplasms Oxygen 2.1117263869
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.1111921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.6315590891 8156442 12507178
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9218705752 15721981 16050911 15700767 16192424 15673190 16097048 16227642 16011737 16124888 10355542 3786805
MESH:D002277 Carcinoma Methylcholanthrene 4.0510545420
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7212619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.7216507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6918566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.6916192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 16.6920056578 19524636
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8919159591 17373747
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 8.2715491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 8.2718759878 12956900 15491423
MESH:D003877 Dermatitis, Contact Oxazolone 10.5815944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 10.5817010967
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0719336974 16227642 15968718 9327722 3732212 2869522 16177239 10915739 6884620 4309450 6623471 17522070 7120509 7440962 10092053 7179309 15998439 15027814 11566570 21278145 19085960 3786805
MESH:D004417 Dyspnea Oxygen 5.0120016425
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 19148513 18566989
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.798156442
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.9018447907
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.2812631006 15959796 12795759 17595544 19224547 61145 16045604 16239168
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0910962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005739 Gas Poisoning Oxygen 5.3920016425
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D005909 Glioblastoma Manganese 3.9817043766
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219900420 19110552
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.7011019492 10880147
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007248 Infertility, Male sodium arsenite 3.0615346721 12646999
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
MESH:D007674 Kidney Diseases Estradiol 6.3115618244
MESH:D007674 Kidney Diseases sodium arsenite 6.3120008137
MESH:D007680 Kidney Neoplasms Estradiol 3.0715610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8611408273 17174718 16943688 17334410 11903743 21278145 17157831 16221502 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4717976157 12389079 16011737 18395914 12649538 18210741 15650968 18054572 15052691 17721639 18277467 17823541 18472332 12445418 15959796 12666154 17869086 14620537 17481882 15730626 14748882 12632514 16136751 17714472 18263696 17698563 15893842 18205269 18472094 16248980 16027843 13678700 18317297 15925388 17944888 12898905 12667390 18251166 16116963 14512876 15057751 15931870 18705752 18279442 18429990 12546737 16192424 18006644 12632512 17557913 17631135 16015684 15362042 15818738 18339082 15338365 18187930 15673190 15876570 17761835 15123356 16638106 17640975 15370692 11481614 10355542 17766677 17922224 20821823 17805973 18481824 14716496 18166357 18376398 14724832 18412020 16033810 17708605 12741479 18420326 12586293 16097048 18156304 14716833 17900296 17525996 12445421 12609069 18395095 18418968 15996030 12958196 17565644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.4714716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1016964402 17285989 15830285 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.722125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7219294768
MESH:D008113 Liver Neoplasms sodium arsenite 7.7215276417 16712894
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.368603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.36598648 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.2419095001
MESH:D055370 Lung Injury Oxygen 4.6518339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6214755239
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6215390079 10545420 16271038 21163286 16337739 7750092 20970405 17909032 11893704 6695378 9230183 1399818 20512841
MESH:D008175 Lung Neoplasms sodium arsenite 3.6216712894 15276417 17306315 19931552 17077188
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211408345 17203775 16891317 11807958
MESH:D020149 Manganese Poisoning Estradiol 13.6019453300
MESH:D020149 Manganese Poisoning Manganese 13.6019453300 16551646 16568477
MESH:D008545 Melanoma Dinitrochlorobenzene 3.8612202904 17334785
MESH:D008545 Melanoma sodium arsenite 3.8619082730 16487513
MESH:D009069 Movement Disorders Manganese 5.1316551646
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009369 Neoplasms sodium arsenite 2.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.9620056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 9.961670384
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009410 Nerve Degeneration Manganese 4.3616551646
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.2112854658
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.823040596 11077013 18394133 12585506 6091946 8156442 6091945
MESH:D010051 Ovarian Neoplasms Estradiol 4.9419401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.9417306315 15276417
MESH:D010300 Parkinson Disease Manganese 3.4111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.5716140633
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2016740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2016039940
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.8014606601
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.6218339021 17627322
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.5020219652 7692837 16940033
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.2918447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.6819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.4512617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.6819075512
MESH:D012878 Skin Neoplasms sodium arsenite 2.7418572023 19524636
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.6819075512 19050374
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8812854658
MESH:D013398 Sudden Infant Death Oxygen 5.7012563064
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5417306315 11723127 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
Pathway ID Pathway Name
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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